Pinned Tweet
Check out our paper and the accompanying perspective by Kuhlman published today in @ScienceMagazine about the surprising role of short tandem repeats in regulating eukaryotic transcription!
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
A thread (1/11):
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
A thread (1/11):
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Connor Horton retweeted
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)
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Connor Horton retweeted
Interested in high-throughput enzyme expression & characterization? Check out @BLEE9239's new preprint describing DA-MEK, which employs hydrophilic/omniphobic surfaces to create droplet arrays compatible w/ cell-free protein synthesis!
biorxiv.org/content/10.110… (1/n)
biorxiv.org/content/10.110… (1/n)
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Connor Horton retweeted
Thrilled to be a part of the Méndez family and looking forward to the symposium!
Congratulations to the eight recipients of the 2024 Dr. Eddie Méndez Scholar Award! This award recognizes outstanding early-career scientists from underrepresented backgrounds who are studying cancer, infectious diseases and basic sciences. Learn more: fredhutch.org/en/news/releas…
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Connor Horton retweeted
Congratulations to our very own Polly Fordyce @fordycelab for receiving @Stanford 2024 President’s Award for Excellence Through Diversity!
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Connor Horton retweeted
For the love of God people just do some experiments, enough with the single cell seq atlases
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It was such a pleasure working with @rosajylee on this project! Check it out!
Hot off the presses!! How does R2 achieve its *exquisite* site specificity? Check out our new study led by former undergrad turned technician @rosajylee, now a PhD student @StanfordMed.
cell.com/cell-reports/f…
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Connor Horton retweeted
Institute Scholar Polly Fordyce @fordycelab, Connor Horton, and team uncovered how highly repetitive regions of "junk" DNA may be linked to a newly discovered mechanism for gene regulation: bit.ly/3VEXlza
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Connor Horton retweeted
Daniel Kahneman was creative by never being content with what had already been achieved. He told us on the @nightsciencepod how to (1) suspend your critical weapons (2) give the mind something to work on while asleep & (3) have ‘adversarial collaborations’
podcasts.apple.com/us/podcast/dan…
podcasts.apple.com/us/podcast/dan…
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Check out new work from @CollinsRNPLab on the RNA requirements of R2 retroelements led by star grad student Anthony!
Classical biochemistry will never die!
We are ecstatic to share this work published in @NAR_open by graduate student Anthony @arodz_var that expands our understanding of RNA requirements for binding and TPRT by the R2 retroelement.
A thread :
academic.oup.com/nar/advance-ar…
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Connor Horton retweeted
A retrotransposon for site-specific gene transfer #NBTNV go.nature.com/4co04Ty
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Connor Horton retweeted
What are the best AI research assistants? Would love a tool that I could ask questions like "find papers with experiment x in model system y", or "has anyone published x + y + z"? Currently using Consensus and its great but fails this type of task most of the time.
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Connor Horton retweeted
How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… @BoXia7
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Connor Horton retweeted
Wrote a 1-pager for @NatureRevGenet on how we should stop pretending transcription factor binding sites are a discrete entity. Just like a cup exists in many states between "full" and "empty", TFBSs are continuous. rdcu.be/dzL8o - feat. sweet new paper from @EKFarley
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Connor Horton retweeted
Retrotransposons found in the genomes of the white-throated sparrow and the zebra finch are shown to safely shepherd transgenes into the human genome, providing a gene therapy approach complementary to CRISPR-Cas9 gene editing. @berkeleyMCB news.berkeley.edu/2024/02/20/jun…
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Connor Horton retweeted
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci - @CollinsRNPLab go.nature.com/3utPERu
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Connor Horton retweeted
Bird bird bird, bird is the word!
Is the secret to safe gene addition a retroelement in birds?
We repurposed the avian R2 element to insert transgenes into human cells (and more!) using RNA-only delivery 🪶
a thread 🧵
nature.com/articles/s4158…
Is the secret to safe gene addition a retroelement in birds?
We repurposed the avian R2 element to insert transgenes into human cells (and more!) using RNA-only delivery 🪶
a thread 🧵
nature.com/articles/s4158…
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Connor Horton retweeted
pretty cool work from the @CollinsRNPLab , congrats to the team on this needed addition to the editing toolkit
Today starts a new era of genome engineering!
We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! @CollinsRNPLab @berkeleyMCB
A thread 🧵:
nature.com/articles/s4158…
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Connor Horton retweeted
Fantastic work by my @CollinsRNPLab colleagues on engineering R2 retrotransposons for gene insertion in safe-harbor loci of human cells! 🔥🤩
nature.com/articles/s4158…
nature.com/articles/s4158…
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Today starts a new era of genome engineering!
We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! @CollinsRNPLab @berkeleyMCB
A thread 🧵:
nature.com/articles/s4158…
We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! @CollinsRNPLab @berkeleyMCB
A thread 🧵:
nature.com/articles/s4158…
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The PRINT system is a completely new approach from
CRISPR and viral gene delivery and we hope it provides
a new path forward for gene therapy applications!
CRISPR and viral gene delivery and we hope it provides
a new path forward for gene therapy applications!
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