My teaching this year clashes with @BiochemSoc SynBioUK 2026 😥 Fear not though, The Biocompute Lab is in strong attendance with posters on (P037) biometrology📏, (P064) genome editing tools🛠️ and (P012) optogenetics💡 and a talk on tunable gene expression at 14:45 today 🎸!
0
1
10
561
Thomas Gorochowski retweeted
The new goal at @AsimovPress is to publish exceptional, technical, long-form reporting on biotechnology; the types of stories that no outlet is doing.
We are allocating most of our budget toward paying great journalists and also artists who can bring these stories to life. The long-term aim is to win a Pulitzer for biotechnology reporting. This also means we'll be publishing less often, because these stories can take 3-6 months to produce.
We'll publish non-reported essays on occasion, but only if they have a thesis that is super compelling and, ideally, could *only* be written by a particular person. (e.g. We have a piece coming up about lead testing, written by a person who is developing those kits.)
Please email editors@asimov.com if you have a big story that you are itching to write; especially if other outlets aren't willing to give you the time or funds to do it properly.
We are allocating most of our budget toward paying great journalists and also artists who can bring these stories to life. The long-term aim is to win a Pulitzer for biotechnology reporting. This also means we'll be publishing less often, because these stories can take 3-6 months to produce.
We'll publish non-reported essays on occasion, but only if they have a thesis that is super compelling and, ideally, could *only* be written by a particular person. (e.g. We have a piece coming up about lead testing, written by a person who is developing those kits.)
Please email editors@asimov.com if you have a big story that you are itching to write; especially if other outlets aren't willing to give you the time or funds to do it properly.
7
33
223
9,690
🚨New work on estabishing design rules for compact CRISPR-based genetic circuitry using Cas12m🧬
Work led by the hugely creative @JoShiv04. My fav bit is a 2-input, 2-output circuit able to regulate two metabolic pathways using only 730 bp of genetic code!
biorxiv.org/content/10.648…
Work led by the hugely creative @JoShiv04. My fav bit is a 2-input, 2-output circuit able to regulate two metabolic pathways using only 730 bp of genetic code!
biorxiv.org/content/10.648…
1
3
20
1,033
A big thanks to @BBSRC, @EPSRC, @royalsociety and others for funding and support. This is the second of numerous strains (SHARK was our first doi.org/10.1021/acssyn…) we are looking to release soon to help accelerate all sorts of synthetic and engineering biology!
0
0
0
87
Thomas Gorochowski retweeted
After recently moving to the University of Oxford, I am currently recruiting PhD students in the broad areas of web systems, social computing and Internet measurements. If you know of anybody, please let them know to reach out (deadline 2nd December)!
5
11
77
3,668
Thomas Gorochowski retweeted
After the labs IPO, there will be many multi-millionaires looking for their next gig.
May I suggest a millionaire - scientist buddy system...
We already have nice labs and plenty of cool, world-changing projects.
All we need is a match-making service. ;)
May I suggest a millionaire - scientist buddy system...
We already have nice labs and plenty of cool, world-changing projects.
All we need is a match-making service. ;)
I mean yeah I hope we do get stunning advances, but I also know how unforgivingly hard biology is, especially to the uninitiated. All these mainstream Ai ppl suddenly caring about Ai is cute and all but they better not waste patient's time. This is actually serious work for once.
5
11
48
2,933
Thomas Gorochowski retweeted
Today is an emotional day for me. Together with Prof. John McCutcheon lab @ASU we have visualized by cryoEM what looks like a very funky ribosome from an insect endosymbiont.
We believe there are important evolutionary implications.
Here the pre-print:
biorxiv.org/content/10.648…
We believe there are important evolutionary implications.
Here the pre-print:
biorxiv.org/content/10.648…
12
36
164
9,037
Thomas Gorochowski retweeted
What the resolution of a neuron model does to the computation? 👇
neurovium.science/posts/pblog-Co…
We show how higher-order neural interactions can appear pairwise under coarse-graining, concealing the underlying computation. Dendritic nonlinearities and their spatial organization matter ity, challenging whether point-neuron networks and scalar weights provide a sufficient abstraction for NeuroAI.
ps. Thanks to Tyler @tylerxhobbs, my writing now fashions the infamous "Fidenza"!
neurovium.science/posts/pblog-Co…
We show how higher-order neural interactions can appear pairwise under coarse-graining, concealing the underlying computation. Dendritic nonlinearities and their spatial organization matter ity, challenging whether point-neuron networks and scalar weights provide a sufficient abstraction for NeuroAI.
ps. Thanks to Tyler @tylerxhobbs, my writing now fashions the infamous "Fidenza"!
0
6
53
2,635
Thomas Gorochowski retweeted
If you’d like to buy the @AsimovPress book in the UK or Europe, please contact Ivy! 👇
Hi! @NikoMcCarty has offered to ship a very large amount of @AsimovPress ’ newest book, Making the Modern Laboratory, to Imperial in South Kensington, London, UK, where I’m offering to help distribute copies of their book. 🧬📚
Link to book: asimov.press/p/modern-lab
0
2
13
2,087
Thomas Gorochowski retweeted
Hi! @NikoMcCarty has offered to ship a very large amount of @AsimovPress ’ newest book, Making the Modern Laboratory, to Imperial in South Kensington, London, UK, where I’m offering to help distribute copies of their book. 🧬📚
Link to book: asimov.press/p/modern-lab
Link to book: asimov.press/p/modern-lab
7
2
7
2,522
Thomas Gorochowski retweeted
@kunjapur We engineer both plants and bacteria to establish non-standard amino acids as a new molecular language for programming plant-microbe interactions. This work contributes to the growing toolkit for precision agriculture and we hope it accelerates the path to a sustainable future!
2
2
16
4,182
Thomas Gorochowski retweeted
⚡️Fully funded PhD opportunity @WarwickLifeSci @uniofwarwick ! We are looking for a talented PhD student to explore bacterial bioelectricity using live-cell imaging and quantitative biology. 🗓️Deadline: 23 Nov 2026 findaphd.com/phds/project/?… #bioelectricity #PhD #PhysicsOfLife
0
6
7
801
Thomas Gorochowski retweeted
Our newest book is finally here!
Making the Modern Laboratory is a spectacular 504-page hardcover that tells the story of everything in the research laboratory and how it came to be, from pipettes to heat-resistant glass to microscopes and more.
It features dozens of articles er appear in print), 100+ full-color images, and original writing from 36 authors. It's printed on Arena Natural Rough paper from Fedrigoni. These books are THICC and would make a great gift for both the science-curious and the working scientist. :)
We have spent the last year working on this project. It has been an insane labor of love. The best way to support our independent science journalism is to buy a copy. <3
Pre-order for $49, with free shipping: press.asimov.com/articles/moder…
Making the Modern Laboratory is a spectacular 504-page hardcover that tells the story of everything in the research laboratory and how it came to be, from pipettes to heat-resistant glass to microscopes and more.
It features dozens of articles er appear in print), 100+ full-color images, and original writing from 36 authors. It's printed on Arena Natural Rough paper from Fedrigoni. These books are THICC and would make a great gift for both the science-curious and the working scientist. :)
We have spent the last year working on this project. It has been an insane labor of love. The best way to support our independent science journalism is to buy a copy. <3
Pre-order for $49, with free shipping: press.asimov.com/articles/moder…
55
104
1,076
66,397
Thomas Gorochowski retweeted
The main preprint from my postdoc is live!
biorxiv.org/content/10.648…
The core idea is to try to make synthetic biology much more systematic and precise, akin to more mature fields of engineering.
This was an ambitious project, it started all the way back in February of 2020 and ng up! Thankfully there were no events in that timeframe, either around the world or specifically here at Harvard, that made things any more difficult than they needed to be.
The fundamental dilemma is that we are often forced to do one of two things when designing a synthetic circuits: either we can navigate a laborious design-build-test cycle where we iteratively optimize a circuit's performance tuning one parameter at a time, or we can screen a huge array of variants using techniques like directed evolution and pick the winners and have little insight into the molecular details of why one design worked better than the others.
Our idea was to try to get the best of both worlds, to combine precise mechanistic insights with extremely high throughput in such a way that we could systematically study the whole design space of a given circuit architecture.
biorxiv.org/content/10.648…
The core idea is to try to make synthetic biology much more systematic and precise, akin to more mature fields of engineering.
This was an ambitious project, it started all the way back in February of 2020 and ng up! Thankfully there were no events in that timeframe, either around the world or specifically here at Harvard, that made things any more difficult than they needed to be.
The fundamental dilemma is that we are often forced to do one of two things when designing a synthetic circuits: either we can navigate a laborious design-build-test cycle where we iteratively optimize a circuit's performance tuning one parameter at a time, or we can screen a huge array of variants using techniques like directed evolution and pick the winners and have little insight into the molecular details of why one design worked better than the others.
Our idea was to try to get the best of both worlds, to combine precise mechanistic insights with extremely high throughput in such a way that we could systematically study the whole design space of a given circuit architecture.
9
40
144
7,747
Thomas Gorochowski retweeted
Design and characterization of peptide-responsive biosensors
doi.org/10.64898/2026.…
doi.org/10.64898/2026.…
2
18
85
7,498
Thomas Gorochowski retweeted
The whole essay is really really good quantamagazine.org/are-memories-t…
1
7
155
10,937
I get goosebumps every time! @SpaceX bringing it!
🚀🌊 A month in Western Australia. A front-row view of Starship’s next chapter.
SpaceX’s Starship Recovery team spent weeks gathering critical re-entry data ahead of Starship V3’s debut flight, tracking the vehicle’s journey from Texas toward the Indian Ocean.
Watching the attempt re-entry from up close is the kind of experience most engineers only dream about.
Every flight creates data. Every failure creates lessons. And every lesson shapes the next Starship. 🔥🌌
1
0
3
273