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Just launched a new tool today to automate marketing for your startup 🙇‍♂️ live on X, with support for Instagram, TikTok & LinkedIn coming over the next few weeks

I wrote a new blog post, "Momentum: An Insidious Factor", on how success begets more success: blakelockbrown.com/blog/momentum-…

Realized today I have some form of "entrepreneurial anxiety", or fear of shipping. Much like social anxiety is insidiously developed from isolation, I believe I developed this from not shipping for a while. I fear the idea's not great, I'll waste effort, people won't like it.

I'm just going to commit to shipping a few new products over the next 4 weeks and see what happens.

This is such a cool paper. They looked at patients who received a COVID vaccine within the first 100 days of starting immunotherapy and found survival rate nearly doubled (likely because the vaccine stimulated the immune system, bolstering it's attack on cancer).

This doesn't imply that receiving a COVID vaccine increases your cancer survival rate. What it does suggest is that bolstering the immune system during cancer treatment likely increases your odds of survival, in this instance through a vaccine.

Excited to see a double-blind RCT to validate these claims, quantify the actual survival rate and rule out any other explanations. Science is awesome.

This year's Network State Conference is on Friday, October 3 in Singapore.

Our speakers include Vitalik Buterin, Bryan Johnson, Ben Horowitz, Brian Armstrong, Amjad Masad, Ranveer Allahbadia, Arthur Hayes, Nas Daily, Noah Smith, Andrew Huberman, and the governments of Singapore, l Salvador.

That means many of the most successful founders, creators, investors, and policymakers in the world are now interested in the idea of bringing online communities into the physical world.

Our conference also features writers, community organizers, and intellectuals from around the world (and across the ideological spectrum!) who are aligning around the concept of fusing offline states with online networks, with ideas ranging from pro-tech regulations to special innovation zones to startup cities.

All this capital and talent going towards the area means that you too can join a startup society that suits you — or found one yourself — even if you're starting out with nothing besides an internet connection.

And by building new societies with defined social smart contracts where everyone has explicitly consented to governance — and anyone can opt out — we can defend capitalism, democracy, internationalism, self-determination, and liberal values in an increasingly illiberal world.

That's the goal, at least. We can only give broad sketches in a tweet. But if you're interested in the long-form version, register to attend in person or remotely at ns.com/conf2025.

Because we’ve started internet companies, we’ve started internet currencies, and now we’re starting internet communities. Come to the Network State Conference to be there at the start.

I asked ChatGPT to pull the odds of creating a unicorn startup based on some of the cities I've lived in vs. where I'm currently living. Man, I need to get back to SF ASAP...

Man, sesame’s voice model is absolutely insane. You have to try this demo. GG @brendaniribe

sesame.com/research/cross…

@iskander points out that this is such a small sample size that the improved survival rate may even be explained away by immunological differences.

x.com/iskander/statu…

So sadly, this study was essentially cherrypicked data to show a benefit. Would love to see more research, but it's not yet a game-changing breakthrough or cure.

So essentially 6/34 total patients (18%) in the study experienced a benefit. Or 6 /16 (38%) of the vaccinated patients.

The way this is worded is misleading.

The study only looked at patients with resectable PDAC which is a minority of patients (10-20% at time of diagnosis).

Also, only 8 out of the 16 patients who received the mRNA vaccine responded. The cancer came back in 2 of the 8.

“The truth is I’m really in pursuit of greatness.

I know people don’t talk like that but I want to be one of the greats.

I'm inspired by the greats.

I want to be up there."

- Timothée Chalamet

We're building a city scale internet for atoms using high speed, underground robots.

Here's a deep dive on how we're solving last mile logistics at scale and making this Pipedream a reality:

Hosted a super chill @builderswhorun 5k in Vancouver today! Great weather, great company and great waffles.

If you're in Vancouver and into entrepreneurship, DM for our next event 🥳

If you know someone with cancer, this might change everything. Two years ago, my dad was diagnosed with stage IV pancreatic cancer—his survival odds under 5%. Doctors pushed chemo. I’m here to share what I wish I’d known then—no quackery, just real hope.

If you or someone you know is battling cancer—or works in the medical field—please consider sharing this post. Together we can accelerate groundbreaking research, and save lives.

Disclaimer: TrialFinder is designed for patients who may not be the best chemotherapy candidates or want additional options. Always consult a medical professional for personalized advice.