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I feel much the same way
there will be within the next few years stunning advances in biology. there will whole new ways to think about what biological study even means. i would be only mildly surprised if there were near term solutions to problems like cancer, neurodegenerative disease, etc
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Proud SEO, never forget your roots!

#fellowship #strong #g50
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Just so wonderful
may London never lose the standing outside the pub on the streets in the summer culture
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Very well put
Luis (and @pietergaricano) are correct below, and @paulkrugman is much too sanguine about Europe's challenges.

As it happens, the same wealth point that Luis mentions also struck me when I traveled to Nashville a few weeks ago.
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On coming back to SF periodically it does feel everyone I know feels very happy about him
BREAKING: New poll shows @DanielLurie is the most popular American mayor.

Key findings:
- 74% of SF voters approve of him
- Majorities support his handling of public safety, downtown revitalization, neighborhood cleanliness
- He earns support from across the political spectrum
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A great person to follow
I think there's a slow, growing realization that "the model will fix it all, and if not the next one will, so all you can do is to wait, there's no way to compete" is bullshit.

It seems obvious to me that there are, and will continue to be, many opportunities in building rage ("scaffold") AI models to address all sorts of problems in sectors and contexts that they know best.

This is efficient even in the face of growing capabilities, for the same reason as it remains more cost effective for a model to call on a calculator rather than to try to resolve the problem internally.

Some reasons for this are proprietary data flows, regulatory needs, deep integration with crusty legacy systems, customer trust earned over time, and tacit knowledge. So to be clear this is not a story about thin wrapper around an API - shallow/fake specialization gets eaten ofc.

People focus on labs because that's sexy, and to be clear they'll continue to be, and I don't think you'll see thousands of companies investing that kind of capex; but I think a big part of the story (and value creation) will look like the nameless businesses that never get discussed on social media, by journalists or commentators.

This is great news for entrepreneurship and shaking up incumbents, and bad news if your view of the world is "the eye of Sauron will simply ingest everything, all that is left is the zero sum fight for power and escaping the permanent underclass".

On the other hand I expect lots of bubbly dynamics and failing businesses and questionable commercial ventures (always has been etc), partly because the territory is still so uncertain that many can still make a quick buck while VCs are in (temporary) Opus psychosis mode. But this too shall pass.
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Really love following Alex and his positivity, highly recommended
If Gemma 4 comes out 5 years ago, the entire world thinks it’s AGI

Today you can run it locally for free on a Mac Mini

God handed us literal magic and completely democratized it

Don’t take this for granted
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This is roughly what my mind is doing. Just swapped out this free local model for a paid cloud one on a personal project and it blew my mind. Congratulations Google
Wait a sec - Google's new gemma-4-E4B is running at 400 tokens per second on my Macbook m5, while Claude Code does 90/tks? And it's free? Same-ish quality as ChatGPT 5.2 I was using last month? 🤯 #gemma #codex #claudecode
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Whether I'm truly a power user or not remains to be seen but wow this is definitely me
Almost every AI power user I know is MORE stressed and busier after using AI, not less

What people thought AI would do: 10x productivity so that we can finish work earlier & relax more

What it’s actually doing: 10x productivity so that we end up with 20x more things to do cos of the sheer possibilities
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Beautiful
Toto Wolff on seeing Kimi Antonelli, George Russell, Lewis Hamilton, and Peter Bonnington on the podium at the Chinese Grand Prix:

"You know, looking at the podium with the three of them up there and, and Bono, the race engineer of Lewis and Kimi, that's probably one of the best moments I've had in Formula 1, to be honest."

[via F1TV]

#F1 #ChineseGP
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I never hoped implementation would be truly accepting everything but this feels hopeful, given Sam's general approach to assessing things. I really want this for our country!
NEW: Britain is the most expensive country in the world to build a nuclear power plant.

The Fingleton Review challenged the Government to deliver a radical programme of planning and regulatory reform to make it cheaper and quicker to build nuclear power plants.

The Government have now published a full response and implementation plan.

Did they deliver 'full implementation' or is it another Labour U-Turn?

Here's @BritainRemade's analysis.

This is a really big step forward.

On safety and reactor design, this is the radical reset of nuclear regulation the review demanded.

On planning, this is the most radical infrastructure reform agenda the govt has put forward yet.

However, it is not 'full' implementation.

Some key measures have been watered down. For example, Habs Regs reforms have become 'updated guidance' and lack statutory underpinning.

Some have been rejected such as the call for statutory time limits for permits and the call to make community benefits a material consideration in planning.

Overall, it's really good news for nuclear (and therefore energy security). This could end up as Starmer's best legacy as PM.

More detail in the blog below.

samdumitriu.com/p/how-serious-…
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This is my current experience
Vibecoding is as much entertainment as it is function
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Wow. I have been saying a lot about the cost of Europe but I feel this really really states it well. Fwiw in the UK folks are really excited whenever I mention doing cool stuff with tech, right now with openclaw!
@sabinedoeringd die meisten Menschen enthusiastisch.
In Europa werde ich beschimpft, Leute schreien REGULIERUNG und VERANTWORTUNG.

Und wenn ich wirklich hier eine Firma baue dann kann ich mich mit Themen wie Investitionsschutzgesetz, Mitarbeiterbeteiligung und lähmenden Arbeitsregulierungen abkämpfen. Bei OAI arbeiten die meisten Leute 6-7 Tage die Woche und werden depentsprechend bezahlt. Be uns ist das illegal.
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This is so deeply my belief
Enshittification is the fakest thing ever. Computers are faster. Running shoes give you more energy return. You can get macro friendly junk food at the grocery store. There is so much good in the world.
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So exciting
🚨🇪🇸 BREAKING — Spanish Scientists Cured Pancreatic Cancer in Rats.
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It is so great. Started my new year's holiday riding it to Heathrow, faster and better than a car even with a transfer on the bakerloo first. Just an awesome thing to have as a country!
Still have to stop and realise sometimes just how wonderful the Elizabeth line is.

This country will only grow with more projects like this supported by government
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Depressing
Complex systems don't survive competency crises.
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So exciting. This seems awesome
I've given them a lot of flak for a lot of their housing policies, but if this actually survives politically this will be massive and they deserve enormous credit for it. The first genuinely big and worthwhile move on housing they've made so far.
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I love the solutions orientation
Stopping local government from gold-plating net zero requirements shows @SteveReedMP’s determination to get more homes built – but there is still more to do. New by me @unherd.

unherd.com/newsroom/strip…
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I think this is important
Watching UK people my age go for degrowth, wealth taxes and bureaucracy is sad.

The UK is a large, kind, functional democracy. These bad policies will harm you, your children and the world.

I know you think we never stop talking about growth, but I think we never start. Where is HS2? Where is a new reservoir? Why is our power so expensive?

If we had grown like the US in the last 15 years (like we used to) we wouldn’t be struggling for this money in the budget. We wouldn’t be out of breath when trying to stop Russian aggression. You’d have more money. You’d be more able to afford a house. We’d have money for prison reform and your other priorities.

I don’t know how to convince you that growth is good. That cities pollute less than building in the countryside. That robot taxis will pollute less and kill fewer people. That nuclear power kills fewer people than coal.

But if we get there, the consequences of degrowth will be very real. It will be more of this. Longer waits at A&E, rarer bin collection, more shrugging at the bad actions of China and Russia.

You think you’re pushing for change. but it will probably be more of the same. And I’ll be sad. So will you. And it will all have been so predictable.
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