Ahmed Balboula retweeted
Two years since the 1st submission, our work on limb heterochrony is finally out! 🎉🎊@CellCellPress
Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl
Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl
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Ahmed Balboula retweeted
Out today in Nature: sex without crossovers.
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s41586…
Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones.
doi.org/10.1038/s41586…
A new extreme of meiotic evolution:
✔️ no crossovers
✔️ no gene conversion
✔️ normal meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
biorxiv.org/content/10.648…
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Ahmed Balboula retweeted
Cambridge → Boston → Cambridge again: I’m thrilled to return to Cambridge(UK) to open my lab @GurdonInstitute @Cambridge_Uni !🥳
(mzhulab.com)
We study how dev timing shapes and being shaped by plasticity, evolution & ageing.
🚩Hiring at all levels: pls email! 📩
(mzhulab.com)
We study how dev timing shapes and being shaped by plasticity, evolution & ageing.
🚩Hiring at all levels: pls email! 📩
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Ahmed Balboula retweeted
New paper from the Rosin lab in collaboration with the Hawley lab 🎉
Spearheaded by postdoc Leif Benner @BennerLeif and wonderful Hawley lab members - We use imaging and RNA-seq to better understand apyrene meiosis in silkworms.
pnas.org/doi/10.1073/pn…
Spearheaded by postdoc Leif Benner @BennerLeif and wonderful Hawley lab members - We use imaging and RNA-seq to better understand apyrene meiosis in silkworms.
pnas.org/doi/10.1073/pn…
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Ahmed Balboula retweeted
We are delighted to share our latest paper in Cell (Cell Press) reporting the earliest known symmetry breaking in mammalian development — at the zygote stage. We show fertilization triggers reproducible proteomic asymmetries that already bias the embryo’s very first decisions.
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Happy to see my PhD student Edgar’s hard work published in Nature Comms! This study uncovers a novel role for myosin X and F-actin in regulating MTOC clustering and chromosome segregation. Congrats, Edgar, and grateful to all coauthors, especially my former mentor @dmooreglover
Happy to share my PhD work in the Balboula Lab; now on @NatureComms! We found that unconventional Myosins X and VIIb localize F-actin to the spindle and microtubule organizing centers (MTOCs) to promote correct spindle architecture/chromosome segregation. nature.com/articles/s4146…
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Ahmed Balboula retweeted
Our paper is now published @CurrentBiology!
With our unique method to live image fertilized mouse eggs, we highlighted the importance of Ca2+ oscillations in maintaining the spindle position to ensure asymmetric cell division. Thanks to all the authors!
sciencedirect.com/science/articl…
With our unique method to live image fertilized mouse eggs, we highlighted the importance of Ca2+ oscillations in maintaining the spindle position to ensure asymmetric cell division. Thanks to all the authors!
sciencedirect.com/science/articl…
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Ahmed Balboula retweeted
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
We collaborated with @DexeusMujer and employed freshly donated for heterologous IVF
1/
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
We collaborated with @DexeusMujer and employed freshly donated for heterologous IVF
1/
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Ahmed Balboula retweeted
I am thrilled to share our new review on holocentric chromosomes. It was a lot of fun to write it together with Ines Drinnenberg!
Same but different: Centromere regulations in holocentric insects and plants sciencedirect.com/science/articl…
Same but different: Centromere regulations in holocentric insects and plants sciencedirect.com/science/articl…
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Ahmed Balboula retweeted
Oocytes are arrested in prophase to give them enough time to grow and accumulate sufficient maternal components.🥚
Our @NatureComms study led by @shiya_cheng reveals two mechanisms repressing cyclin B1 translation to maintain this arrest.
bit.ly/4fVHgMz (1/6)
Our @NatureComms study led by @shiya_cheng reveals two mechanisms repressing cyclin B1 translation to maintain this arrest.
bit.ly/4fVHgMz (1/6)
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Thank you very much, Gabriele!
It's Sunday again and a new issue of #cebooc is out! Pick your favourite paper on #oocyte cell #biology here:
biomed.news/bims-cebooc/20…
This week's highlight is @abalboula1 work on DNA damage and autophagy in oocytes: pubmed.ncbi.nlm.nih.gov/39487138/
Thanks to @Bims_BiomedNews for preselecting.
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Happy to share our latest publication in Nature Communications led by active graduate students, Fei Sun and Nourhan Ali! We found that increased DNA damage in full-grown oocytes correlates with diminished autophagy activation. nature.com/articles/s4146…
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I am thankful for the great collaboration with @danilondo58 @amk1017 @APattLab Peter Sutovsky @RocioMRivera @csimintiras @msofia2009 Yuksel Agca Masashi Takahashi and Joe Qiao.
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Ahmed Balboula retweeted
Woohoo, it's out! Our exciting publication in @PNASNews on genetic variants in kinesin genes that alter egg aneuploidy in humans. pnas.org/doi/10.1073/pn…
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Ahmed Balboula retweeted
The latest from @QuinnHoorn - the paper was designated Editor's Choice by @BiolReprod. Thanks everyone involved.
Machine learning to identify endometrial biomarkers predictive of pregnancy success following artificial insemination in dairy cows† academic.oup.com/biolreprod/art…
Machine learning to identify endometrial biomarkers predictive of pregnancy success following artificial insemination in dairy cows† academic.oup.com/biolreprod/art…
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Ahmed Balboula retweeted
🚨New preprint on “decoupling the peri-centromere from the kinetochore” in Peromyscus mice🐭
Congrats to our postdoc @Eddie53467802 for leading this work together with @micro_MelBruno in @todd_macfarlan lab!
biorxiv.org/content/10.110…
Congrats to our postdoc @Eddie53467802 for leading this work together with @micro_MelBruno in @todd_macfarlan lab!
biorxiv.org/content/10.110…
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Excited to share the publication of 'Molecular Mechanisms Determining Mammalian Oocyte Quality', edited by me, including outstanding chapters from Karen Schindler @KASchindler27, Jennifer Wood @ProfJen2695, Joe Qiao, So-Youn Kim @so_youn_kim and Mike Lampson, and their teams.
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Ahmed Balboula retweeted
Thrilled to share I will be joining the Department of Cell and Dev. Bio. @CUAnschutz as an Assistant Professor starting Jan 2025! My lab will investigate the mechanisms that regulate genome integrity and how these processes are rewired across disease, development, and evolution
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Ahmed Balboula retweeted
Congratulations to Inwon Lee for some great observations and beautiful movies. When investigating how mitochondria move in eggs and embryos, we found Trak2 caused aggregation into 'mitoballs'. Nuclear position, shape and function were all disrupted and embryos failed to develop.
A study studying cell organisation led by Inwon Lee, @DeepakMonash, @jcarrollmonash in @PNASNews reveals that disruption of #mitochondrial distribution by forming 'mitoballs' displaces nuclei & disrupts early #embryo development: bit.ly/4cIuQG6 10.1073/pnas.2317316121
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