Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…

1/8 The Human Gut Cell Atlas (HGCA) v1.0 is out on bioRxiv! doi.org/10.64898/2026.…
Built by the gut community, for the gut community. For this HCA resource, we aimed for high-resolution healthy cell subtypes and robustness for downstream tasks like label transfer.

This week would have been Dr. Jane Wu's 63rd birthday. Instead, her family is grieving after she died by suicide following years of unjust, cruel scrutiny by the Trump administration.

Dr. Wu spent her career pushing the boundaries of neuroscience and building a life in the country she chose to call home. Yet she was treated as a suspect simply because of her ancestry. She was never charged with wrongdoing, and the investigation into her ended without a finding of misconduct. But the damage was already done.

Racial profiling of brilliant scientists destroys lives and careers, drives away talent, and makes our country weaker.

We owe it to Dr. Wu to ensure programs like the China Initiative are never revived and no researcher is ever again treated as a suspect because of where they or their family come from.

“He agrees with critics that the China Initiative damaged the reputations of many innocent scientists and “deterred good people from coming to the U.S.” But he also thinks it “has helped the country more than it has hurt the country by deterring bad people from coming here … and making the country safer.” And he strongly defends the government’s tactics.”

China Initiative destroyed the lives of many innocent scientists and led to the death of the innocent Professor Jane Wu.

I wonder whether Dao and other @RiceUniversity leadership similarly defend the Japanese American internment camps during WW2, which imprisoned all Japanese Americans with 1/16 Japanese heritage, children under 10, seniors above 70, and people with disabilities, since the camps likely deterred spying activities.

A foundermental issue of the infamous China Initiative is its “punish-first-until-proven-innocent” approach. This immoral and un-american approach was not addressed by Dao in this report. Innocent Chinese American scientists should not be considered and treated as “necessary sacrifices” for any purpose, and be subject to such injustice.

By the way, claiming that FBI agents know better about how the world works is completely false. One piece of false evidence against Professor Anming Hu was a wrong translation FBI generated using Google Translate. In Professor Franklin Tao’s case, the procecutor argued in court “who would work for free?” We academics work for free all the time in routine academic activities. What FBI and Dao call “facts” are questionable. They are just common blokes too.

After China Initiative, Dao landed the likely much better paid position of Associate Vice President of research security at Rice University. Such great career incentive for FBI agents to start the next China Initiative, regardless of the many innocent lives destroyed.

● Twist, unwind, repeat. Dr. Chongyi Chen (NIH) investigates the forces that keep our DNA topologically balanced—and what happens to gene regulation, chromatin architecture, and genome stability when that balance is disrupted! :nyulangone.zoom.us/webinar/regist… #chromatin2026

1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @Anders_S_Hansen!

We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions:
biorxiv.org/content/10.648…

Check out our new preprint led by @mileshuseyin unexpectedly discovering Polycomb 3D interactions independent of cPRC1.

Miles led this ambitious study. He's also on the faculty job market, and I can't recommend him highly enough for important and comprehensive science!

1/ Excited to share our new preprint from a joint collaboration between @JswLab + @bruce_ksander!

Aging is marked by a progressive loss of resilience to stress. Can we systematically search the human ORFome for genes that make vulnerable cells more resilient?

Performing such a genome-scale ORF screen led us to NKX2-5—a heart transcription factor we engineered to restore vision, and improve health in aged mice.

A breakdown🧵
🔗 doi.org/10.64898/2026.…

Thank you to Boston Children’s Hospital for highlighting our recent publication, describing:
Receptor Free Signal Transduction.
childrenshospital.org/newsroom/media…

The next big questions in immunology dlvr.it/TVf2tH

Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
nature.com/articles/s4158…

Congrats Daniel & @jkagan1 for another landmark study! 👏👏Many systems showed how expression kinetics can be encoded with receptor based signaling - frequency & duration signaling 👉gene expression. Couple signaling-some to gene beyond time-scale of receptors is a game changer!

SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more.

Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell cell.com/cell/fulltext/…

just talked about this idea with lab and saw this work coming out! congrats to @ReganVolk @amycfanphd and all. it is challenging to target specific macrophage subtypes but possible to do it based on on their interacting cells?nature.com/articles/s4158…

Very excited to share our new paper in @CellReports - the first Adler Lab in-house paper! 🎉

Led by @SYonassi, @noaGoldenber & @AviaWalfisch, together with @Eitan42Cohen, @Einat_Tamar & @XuZhouLab.

We ask how supportive cells coordinate division of labor across tissues.
🧵

First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
nature.com/articles/s4158…

How to turn unprecedented cellular data into insights of tissue function? #TissueUnits, #DivisionOfLabor, and tissue-specific #Archetype. Congrats to @MiriAdler &team, go-to for tissue systems biology adler-lab.com🔥honored being a small part👇
sciencedirect.com/science/articl…

Come be our colleague 👇🫵

🚀Please help share widely! We're excited to launch the new #AI4BIO #Fellows Program @SCSatCMU to recruit exceptional early-career scientists pursuing bold, independent research at the intersection of AI and biology.

Fellows will be supported by The Center for AI-Driven I4BIO) @SCSatCMU and co-mentored by two CMU School of Computer Science faculty members, with opportunities spanning AI models, computational biology, and autonomous science, including engagement with the CMU AI Science Foundry (ai-science-foundry.cmu.edu).

We are looking for truly exceptional candidates who want to help define new directions for AI-driven biomedical discovery.

📅 Apply by November 15, 2026.

🧬 Program information: cmu.edu/ai4bio/apply/i…
🤖 Application via Interfolio: apply.interfolio.com/190197

@chadmaximusjrting your bubble but NASA's Apollo program relied heavily on a contingent of first-generation German immigrant engineers and scientists—brought to the U.S. via Operation Paperclip after World War II—who led crucial development, testing, and launch infrastructure operations. You are showing German talents your former competent political leaders brought into the U.S. through another mechanism to make it to the moon.

Awesome work from @Anders_S_Hansen @bloodgenes 👏👏chromatin looping regulates precise expression control during embryogenesis 👍