Congrats @ShengWangD on your recently published work, which establishes a clear contribution of rare variants on Chromosome X to male-biased psychiatric disorders and identifies a new X-linked high confidence autism gene, MAGEC3.

linkedin.com/posts/jeremy-w…

New UCSF-led research reveals the complex interplay of #genetic factors contributing to male-biased prevalence in #autism spectrum disorder, #Tourette syndrome, and #ADHD, paving the way for future advancements in #neurodevelopmental disorder research.

nature.com/articles/s4146…

And as always, this work would not have been possible without all of the patients and their families that so generously participated in this research #Autism #tourette #ADHD

@UCSFPsychiatry @SFARIorg @Spectrum @TouretteAssn @CHADD_ADHD

Thanks to everyone in the @WillseyLab, especially @belinda_p_wang and @snw555, as well as our fantastic collaborators, including Vanessa H. Bal, Gary Heiman, Jay Tischfield, Thomas Fernandez, and Matthew State.

Very excited to present our recent preprint! This was a massive effort over the past three years that investigates the complex biology of high-confidence ASD (hcASD) genes during early timestamps of neurogenesis using single-cell CRISPRi.
biorxiv.org/content/10.110…

Congrats Nawei and Noam for conducting the largest CRISPR-based screen of high confidence autism risk genes conducted to date. Follow the link for more details!
@snw555 @noamteyssier @belinda_p_wang @fimazaltsman @MartinUCSF @UCSF @Spectrum @SFARIorg

linkedin.com/posts/jeremy-w…

Congrats @belinda_p_wang , Rasika, @fimazaltsman , @SnowNaing1 and the rest of the team for creating a comprehensive map of the protein-protein interactions of 100 high confidence autism genes

@WillseyLab @KroganLab @UCSFPsychiatry @Spectrum @SFARIorg

linkedin.com/posts/jeremy-w…

Thanks to our many collaborators, especially Matthew State @rhuttenhain , @LabNowakowski , @goodfrognosis , and the rest of the @pcmi

Jeremy Willsey, PhD, highlights the potential of targeting interacting proteins, opening doors to treatments benefiting larger groups of autism spectrum disorders patients. A step towards more effective clinical trials.

psychiatry.ucsf.edu/news/how-prote…

Check out our new preprint quantifying the contribution of rare X-linked genetic variation to three male biased neurodevelopmental conditions: autism, Tourette syndrome, and ADHD medrxiv.org/content/10.110… @UCSFPsychiatry @QBI_UCSF @PsychCellMap @ucsfrrtp @SFARIorg @spectrumnewsorg

Recent studies, by @goodfrognosis, A. Jeremy Willsey, @belinda_p_wang & Matthew W. State, have gained insights on compounding genetic risks for autism spectrum disorder and are closer to developing therapeutical interventions. @WillseyLab
🧬ucsfpsy.ch/3vANFs8🧬

Studies have identified a growing list of associated risk factors for autism, and—with the use of gene editing tools, multidimensional omics datasets, and higher-throughput model systems—possible therapies. @goodfrognosis @belinda_p_wang @WillseyLab
🧬ucsfpsy.ch/3MkLTkq🧬

Genomics, convergent neuroscience and progress in understanding autism spectrum disorder – a new Review by Helen Rankin Willsey, A. Jeremy Willsey, Belinda Wang & Matthew W. State
@goodfrognosis @belinda_p_wang @WillseyLab @UCSFPsychiatry @UCSF

go.nature.com/3EKAUOR

Proud to have our review paper published online today in @NatRevNeurosci

Also feel very fortunate to have such wonderful co-authors in @goodfrognosis @belinda_p_wang and Matt State

@UCSFPsychiatry @QBI_UCSF @PsychCellMap

nature.com/articles/s4158…

And special thanks to @ShengWangD for his tireless work in creating and revising Figure 1!

Today is Tourette Syndrome (TS) National Advocacy Day! Support this effort by sending a pre-written letter of support to your Representative and Senators helping them understand the public policy priorities for TS and Tic Disorders. #Rally4Tourette tinyurl.com/wjfh3zrp

NJCTS Advocates Call for a Stop to Tourette Syndrome Stereotypes: youtube.com/watch?v=HQVKCM…

Check out our latest work studying comorbidity between autism and congenital heart disease. Great collaboration with @TreyIdeker @sbr28 @WillseyLab and Khokha lab authors.elsevier.com/c/1dbe98YyDffJ…