Aging: the "antennas" of cells open a new path against chronic diseases
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Reducing age-related disease incidende will have a profound effect on our healthcare landscape. Prof. Kenneth Thorpe from Emroy University and the Partnership to Fight Chronic Disease discusses these issues in his fantastic editorial in our Article Hub.
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In an upcoming webinar we will discuss why G protein-coupled receptors may be central to healthy aging. We will discuss how coordinated, network-level approaches could address several drivers of aging at once.
lnkd.in/ejYQy4t4
lnkd.in/ejYQy4t4
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Here's a second insightful editorial, from our Article Hub, written by Professor Marta Filizola, discussing how the next steps of context-specific data collection are vital for implementation of geroprotection systems in medicine.
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G protein-coupled receptor digital twins for precision and personalized medicine | Computational and Structural Biotechnology Journal spj.science.org/doi/10.1016/j.…
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Here's an excellent editorial, that forms part of our Article Hub, written by Professor Thomas Sakmar (@tomsakmar) discussing how the GPCR-ome serves a central regulator of human healthspan. It is a tremendous honor to have his contribution to our Hub.
frontiersin.org/journals/scien…
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...here's a short video from our lab in conjunction with our article hub with @FrontScience. We are working towards a future without disease.
youtube.com/watch?v=Di-JRM…
youtube.com/watch?v=Di-JRM…
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..inspiring young people about science is one of the most important parts of my job. With the help of
@Frontiers for Young Minds we have created an accessible version of our recent paper where we propose that multi-disease therapies may be coming soon!
kids.frontiersin.org/articles/10.33…
@Frontiers for Young Minds we have created an accessible version of our recent paper where we propose that multi-disease therapies may be coming soon!
kids.frontiersin.org/articles/10.33…
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...I'm so happy for our work to be in such a fascinating repository! (Database of Original & Non-Theoretical Uses of Topology). Data topology is such an intriguing field!
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Why Single Target Drugs Fail Complex Disease!
music.youtube.com/podcast/6zs_dE…
music.youtube.com/podcast/6zs_dE…
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...exciting times for the Receptor Biology Lab and @MoffittNews at @Speros_Florida. We will be able to develop novel radiopharmaceutical interventions at an unprecedented scale.
nuclionews.com/article/moffit…
nuclionews.com/article/moffit…
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Understanding how GPCR (G protein-coupled receptor) signaling systems control cellular resilience systems may be an entry point into developing therapeutics to a wide range of cancer conditions.
bioengineer.org/gpcr-signaling…
bioengineer.org/gpcr-signaling…
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Our paper investigates how functional re-programming of cellular resistance - through intelligent GPCR network interventions - could forestall the chronic accumulation of damage that triggers the generation of multiple disease states.
medicalxpress.com/news/2026-10-r…
medicalxpress.com/news/2026-10-r…
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...thanks @TimePieChina for the R/T
This review explores how combinatorial #GPCR-based strategies (e.g., coupled with senolytics) hold compelling promise to delay multiple hallmarks of aging and enable personalized anti-aging GPCR therapies based on multi-omic biomarkers. @StuartMaudsley
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...here's a link to our science 'hub' for our article!
frontiersin.org/news/2026/10/2…
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...great news, our latest article is out! A huge thanks to all of my collaborators and the amazing team at Frontiers for helping put all this together!
Could targeting cell-signaling networks help tackle several age-related diseases at once?
Read the lead article in Frontiers in Science ➡️ frontiersin.org/journals/scien… ⬅️ by Tabitha Boeringer, @StuartMaudsley, @THebertMcGill, and more.
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...back in the '09, we were looking at the u-curve of somatic metabolism and its effect upon life/healthspan modification.
link.springer.com/chapter/10.100…
link.springer.com/chapter/10.100…
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...the famous u-shape curve of life. It's everywhere but there are more hidden complexities in there!
Imagine following nearly 13 million real people for more than 10 years just to see what cholesterol level helps them live the longest. That is exactly what Korean scientists did in a giant 2019 study. They tracked 12.8 million adults who had check-ups between 2001 and 2004, and l 2013. More than 694,000 people died during that long stretch.
The results were clear and surprising. Cholesterol and death formed a U-shape. Very low cholesterol was linked to higher death rates. So was very high cholesterol. The sweet spot for the longest life was 210 to 249 mg/dL for most adults. That is higher than many doctors call “ideal.” Younger people had a slightly lower best range, but still not the super-low numbers often pushed today.
Because the study lasted so many years, reverse causality is less likely to explain the low-cholesterol danger. Reverse causality means a hidden illness might lower your cholesterol right before it kills you. With more than a decade of follow-up, early sickness cannot easily account for the extra deaths seen in people who started with low cholesterol. The pattern held across ages and for both men and women.
The huge number of people—almost the entire adult population of a country—makes the findings hard to ignore. Smaller studies can be wrong by chance. This one is massive. It shows that moderately higher total cholesterol, not the lowest possible number, went with the best chance of living longer in this large group.
In short, the biggest study of its kind found that cholesterol levels in the low-to-mid 200s were tied to the longest lives, and the long tracking time makes it tougher to blame the higher death rates at low levels on reverse causality alone.
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