If you are an early career researchers looking for experience on a grant evaluation committee have a look at this.

Cure Parkinson's @CureParkinsonsT offers 2-3 seat on our committee to ERCs every year (4 meetings)

Just one week to go before the deadline!
cureparkinsons.org.uk/2026/09/2027-r…

We are looking for early career #Parkinsons researchers (PhD students or Postdocs working in the UK) to get 12 months experience on the @CureParkinsonsT Grant Evaluation committee. There are 4 meetings per year & you will be provided with mentoring

@CureParkinsonsT It involves:
Meeting #1: You observe (virtual meeting)
Meeting #2: You contribute to the discussion (hybrid)
Meeting #3: You are a secondary presenter of a grant application (virtual)
Meeting #4: You are primary presenter for a grant application (in person meeting+nice dinner!)

Researchers report triglyceride/high-density lipoprotein cholesterol ratio - a surrogate marker of insulin resistance, "may provide prognostic information & help identify early-stage #Parkinsons patients at risk of worse disease progression"
prd-journal.com/article/S1353-…

CD38 is an interesting target. Now @cerevance researchers present preclinical data showing that CD38 inhibition (via their CD38 inhibitor CVN14)⬆️neuronal survival &⬇️α-synuclein in vitro, elevates brain NAD+, &⬇️motor deficits in a rat #Parkinsons model
frontiersin.org/journals/pharm…

Researchers report that "SV2A PET reveals disease-specific patterns of reduced presynaptic availability, consistent with synaptic loss, across parkinsonian disorders, supporting its potential as a diagnostic & monitoring biomarker"
journals.sagepub.com/doi/10.1177/18…

New research suggests that "altered branched-chain amino acids metabolism may represent a prediagnostic metabolic feature of #Parkinsons & support further investigation of its biological & translational relevance"
nature.com/articles/s4153…

Thank you to everyone who attended our Autumn Research Update Meeting last month!

You can now catch up on the recordings from the event. The meeting discussed neurotrophic factors, a group of proteins that help with the growth of nerve cells. Watch now: buff.ly/LMjgDG4

High-throughput plasma proteomic profiling identifies novel biomarker candidates in #Parkinsons with cognitive decline; 68 controls vs 130 PD (varying cog.); SAA1 was found to be associated with both cog. & motor impairment - from @PerSvenningsson et al
mcponline.org/article/S1535-…

Researchers report PIKfyve inhibition induces #Parkinsons-associated LRRK2 activation through phosphatidylinositol 3-phosphate & conjugation of ATG8 to single membranes (CASM)
life-science-alliance.org/content/10/1/e…

Researchers have developed a gait foundation model for 3-dimensional skeletal motion, which was recorded via a single-depth camera during 5 motor tasks, from 3,328 deeply phenotyped adults in the Human Phenotype Project
nature.com/articles/s4159…

The results "establish gait as an independent, multisystem biosignal, motivating integration of gait analysis into routine clinical assessment as a scalable, passive vital sign" - useful new tool for #Parkinsons?

Using normative brain-charts analysis, researchers propose choroid plexus enlargement as an imaging correlate of cognitive impairment in #Parkinsons
nature.com/articles/s4153…

New review discusses "the converging shared underlying molecular mechanisms that link the ‘acute’ SARS-CoV-2 infection that often only lasts for days & ‘chronic’ neurodegenerative diseases that often take decades to develop"
link.springer.com/article/10.100…

New preclinical data finds that α-synuclein pathology leads to reductions in neuronal activity in cells with somatic inclusions & reciprocal changes in local population activity but does not impair visuoperceptual function
nature.com/articles/s4153…

Another study suggesting dietary & supplement-based Mediterranean-ketogenic diets appear safe in patients with #Parkinsons, but do not markedly alter the gut microbiome. Modest anti-inflam effect of medium-chain triglyceride-supplemented Mediterranean diet
cell.com/iscience/fullt…

Researchers hypothesized that “replenishing” BDNF may ameliorate graft-induced dyskinesias (GID), but BDNF supplementation exacerbated them. Evidence suggests a maintained immature dopamine/glutamate co-expression phenotype contributes to GID expression
nature.com/articles/s4153…

Researchers introduce personalisation & evaluation of human whole-body metabolic models & community microbiome models using "Persephone"
nature.com/articles/s4159…

New research from @MXHend & @VAInstitute colleagues suggests "that Lewy pathology accumulates at excitatory corticostriatal synapses prior to overt synaptic degeneration and could contribute to cognitive decline in Lewy body diseases"
academic.oup.com/braincomms/art…

Rezera (formerly NodThera) is aiming for a $181M IPO to help take its NLRP3 inhibitor ruvonoflast, (a brain-penetrant NLRP3 inhibitor) through phase 3 testing next year in peripheral artery disease, with a 2028 readout. Opportunity for #Parkinsons?
fiercebiotech.com/biotech/rezera…