GLP-1 receptor agonists are among the most effective treatments for obesity and other metabolic disorders. With widespread use of these drugs, it has become clear that their effects go well beyond health conditions traditionally linked to metabolism, affecting multiple other arly the brain.

Continued research in this field has also expanded beyond the GLP-1 receptor as a target, with the development of additional drugs and combinations to help optimize patient care.

Learn more in this special issue of Science: scim.ag/4yX17UB

Happy 159th Birthday, Marie Skłodowska Curie! What remains to be said of this scientific icon?

In the book The Elements of Marie Curie, Dava Sobel "offers a vivid narrative that uses Curie’s well-known story as scaffolding for tales of the brilliant young women who trained in of her scientific legacy."

Read the #ScienceBooks Review: scim.ag/4Acs9bs

"I still find the AI assistant helpful for refining routine correspondence. But I have found it can get in the way of connecting with the people closest to me." #ScienceWorkingLife scim.ag/3UCwrK7

New experiments present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in #immunology. @scisignal scim.ag/48vIWKO

A new approach to stimulating protein degradation could expand the therapeutic potential of targeted treatments for complex neurodegenerative diseases involving multiple dysfunctional proteins, according to a new study in Science. scim.ag/4iASGIA

A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself.

Learn more: scim.ag/3ViJIUV #ScienceMagArchives

Healthy remodeling of adipose tissue helps maintain metabolic balance and protect surrounding organs. But when this process is disrupted, it can lead to harmful cellular changes that contribute to metabolic disease and that damage nearby tissues. Although weight loss can reverse sue dysfunction, some changes may persist.

According to a new #ScienceReview, understanding which changes are reversible and which leave lasting effects is key to helping researchers develop treatments that don’t just reduce fat mass, but also restore healthy fat-tissue function and improve metabolic resilience.

Learn more: scim.ag/4k0ob14

The November 2026 issue of Science #Immunology is live!

This month's cover depicts immune cells being modified directly within the body, highlighting a new Review on in vivo #immunoengineering.

Learn about this work and more: scim.ag/4iE3J3F

A new toothbrush generates electricity through bristle movement to battle plaque-producing bacteria.

Learn more in @ScienceAdvances: scim.ag/4f9OdeM

People are buying consumer-grade brain wave detectors ostensibly to help with sleep, concentration, and meditation.

But as journalist Jonathan Moens describes in the latest #SciencePodcast🎙️ episode, companies are getting more than the price of the devices in the ning data for AI models—in many cases without the consent of the user.

🎙️ Listen here: scim.ag/4zptwUh

By studying G protein–coupled receptors in mouse hippocampal slices, scientists provide new evidence of unconventional receptor signaling that has implications for the function of synapses in the brain. @scisignal scim.ag/3WMyAUl

Science is publishing an Erratum for the August 2026 Research Article “RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation.” scim.ag/47VQWET

To mathematicians, the torrent of breakthroughs artificial intelligence has catalyzed in their field has been head-spinning.

Often running hundreds of pages, the new proofs can be so dense as to be nearly incomprehensible. To reassure mathematicians they are correct, #AI any discoveries with certificates from Lean: a computer program that checks proofs with seemingly unimpeachable rigor.

But these guarantees may not be as airtight as they seem. Learn more: scim.ag/4BEDzGv @NewsfromScience

"In the end, I have come to realize that being authentic at work is not a weakness, but rather a strength." #ScienceMagArchives scim.ag/44LmCvh

A small molecule improves the fitness of cells containing diseased mitochondria.

Learn more in a new #SciencePerspective: scim.ag/4jOhL50

In a new @SciImmunology study, researchers used antibody samples from people likely vaccinated against smallpox to identify monoclonal antibodies for new antigen targets in Mpox, paving the way for future vaccines and therapies. scim.ag/4yOJlmo

Habitat fragmentation may be causing birds to lose genetic diversity far faster than previously estimated.

A new Science study of 62 songbird species in China found that all had lost nearly half their genetic diversity over roughly 50 years, including species considered common nction. scim.ag/4AtWz9F

For their work in rethinking sustainable farming in Africa and understanding what drives behavioral change in addiction, Willy Mulimbi and Peter Soyster, respectively, are each a winner of the 2026 NOMIS & Science Young Explorer Award. 🎉

📃: scim.ag/4z22H7K
📃: scim.ag/4sLHIVp

Today there's a special outstanding @ScienceMagazine issue on GLP-1 drugs, obesity and adipose tissue
science.org/doi/10.1126/sc…
A thread below to summarize some of the papers

An analysis of hair in a 2800-year-old tomb in Siberia has yielded the earliest direct evidence of psychoactive cannabis use.

The findings in Science shed light on the plant’s role in ancient societies. Learn more: scim.ag/482jWe5