Read our latest #research "The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation" published in Sci Rep (2026). https://doi. org/10.1038/s41598-026-42811-6

Read our latest #research "A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients", published with @SpringerNature in @NatureSMB
nature.com/articles/s4159…

Read our latest #research "Import mechanism of peroxisomal proteins with an N-terminal signal sequence", published with @SpringerNature in @NatureCellBio
rdcu.be/elkQ3

Excited to share our latest work led by our postdoc Dan Zhao! We uncovered how the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase (Pdi1) initiates ERAD. A long-sought ERAD reductase is finally discovered! nature.com/articles/s4159…
Huge congratulations!

Mystery unveiled! Peroxisomal protein import resembles that of nuclear pore! Congratulations to Yuan and Mike for their joint effort! Thanks to @HHMINEWS for their continuous support on this project! …science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/sc…

We are thrilled to share our new work published in Nature today reporting a long-sought peroxisomal retrotranslocation channel formed by a ubiquitin ligase complex. Phenomenal work by our postdocs Peiqiang Feng, Xudong Wu and collaborators.
nature.com/articles/s4158…

Our story on substrate translocation mechanism by Cdc48 is online now. Check out this Christmas present here authors.elsevier.com/c/1eIIX3vVUPGL…. Big thanks to everyone for their excellent contributions.

@ZhejianJ @jrengen @GygiLab

Check out our new preprint on the translocation mechanism of the holy-grail Cdc48 ATPase. Congrats to @ZhejianJ and Hao Li, as well as to our wonderful collaborators the Engen lab @jrengen , the Marto lab, and @GygiLab !

Legobodies are online now, with full sequences available! Have fun!👉pnas.org/content/118/41…

Excited to share our study on the mechanisms underlying selective autophagy of lipid droplets. We showed that Troyer syndrome protein spartin is a key to this! A wonderful collaboration with @synapsepark and @TalleyJLambert. Amazing support:@DamonRunyon biorxiv.org/content/10.110…

Check out our new preprint on Making the nanobody Big again for Cryo-EM, spearheaded by Xudong Wu (will start his own lab at Westlake University soon) in the lab.👉
biorxiv.org/content/10.110…

Check out our new review on protein translocation through a distorted lipid bilayer.

authors.elsevier.com/c/1cVIr3QxxSjU…

Want to know what will happen if a membrane protein is too good at generating curvature? Check our new paper
nature.com/articles/s4146…

#CryoEM structure of the post‐translational Sec #translocon with substrate bound and X-ray/HDX of the Sec62 subunit.
➡️ @embojournal paper online now!
Congrats to @tw_weng, @jingdongcheng, @BangeBalcony and everyone involved! 🎉👏
embopress.org/doi/abs/10.152…

Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage biorxiv.org/cgi/content/sh… #bioRxiv

New work from @Salic_Lab on Hh co-receptors. Wonderful PhD work from Brad. Congratulations!

Congrats to our former PhD student, Marco Catipovic (now at @GreenLabJHMI), on his paper in @emboreports: "Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase" #ATPase #translocation

embopress.org/doi/abs/10.152…

New work from our next-door neighbors @Salic_Lab ! Congratulations @KP_BioMed and Brad Wierbowski!

cell.com/developmental-…

The SecA motor generates mechanical force during protein translocation: nature.com/articles/s4146…