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Thrilled to share companion stories from our lab, out today in @ImmunityCP and @CellReports . We characterize an enzymatic TIR protein as an immune sensor in animals. See tweetorial from @UMassChan @UMassMDPhD student @tse_elegans
cell.com/immunity/fullt…
cell.com/cell-reports/f…
cell.com/immunity/fullt…
cell.com/cell-reports/f…
Stoked to share our companion stories, now out in @ImmunityCP and @CellReports! We characterize an enzymatic TIR protein as an immune sensor in animals, showing that it is a guard protein in an effector-triggered immune response. cell.com/immunity/fullt… cell.com/cell-reports/f… 1/
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Congratulations to this 🌟!! @UMassChan @UMassMDPhD student @tse_elegans has achieved every measure of success possible during her MD and PhD training, culminating the the Dean's Award for best PhD thesis. Congrats Sammy. I couldn't be more proud. #UMassChan2026
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#PhDone! Congrats to @UMassChan @UMassMDPhD student Akshay Alaghatta on his successful defense today! PhD #6 for the @RPWLab
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Pukkila-Worley Lab is also @rpwlab.bsky.social retweeted
Check it out!! Stellar matches for our MSTP students!! Congrats to our double docs on this milestone in their professional careers as physician-scientists! These sites are so lucky to have you. We are immensely proud! #Match2026 #MDPhD #UMassChanMatch
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Beaming with pride this afternoon for @tse_elegans, a star MD-PhD student from my lab, and 5 other @UMassChan @UMassMDPhD students after INCREDIBLE Match Day Success! Sammy heading to the Pediatric Residency at Boston Children's Hospital!
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@BostonChildrens @MayoClinic x 2 @bcmhouston @BrighamWomens @MaineMed ! Incredible @UMassMDPhD graduates are heading your way!!
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Pukkila-Worley Lab is also @rpwlab.bsky.social retweeted
New publication alert! Five MD/PhD students on the same paper? Now that's what we call collaboration! Congrats to our students, alum, and co-director Dr. Mark Johnson on their new publication!
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2025 RPW Lab Outing! This year, a hike up Mt. Watatic on a blue bird day. Love our lab!!! :-)
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Pukkila-Worley Lab is also @rpwlab.bsky.social retweeted
Read Pukkila-Worley, MD, is the new director of the MD/PhD program: direc.to/n8PN
Dr. Pukkila-Worley has mentored dozens of MD/PhD graduate students since joining @UMassChan in 2014. The @RPWLab studies host-pathogen interactions and bacterial pathogenesis. @UMassMDPhD
Dr. Pukkila-Worley has mentored dozens of MD/PhD graduate students since joining @UMassChan in 2014. The @RPWLab studies host-pathogen interactions and bacterial pathogenesis. @UMassMDPhD
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Check out the cover of @TrendsImmuno !! Art by lab alumna @tse_elegans to highlight our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! cell.com/trends/immunol…
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Incredibly proud of @Mo_AliNasrallah , a @UMassChan @UMassMDPhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025
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Excited to share another review from the lab, out this week in @TrendsImmuno . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! cell.com/trends/immunol…
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Excited to share our recent review out in @NatRevImmunol . We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. @UMassChan
Patterns of pathogenesis in innate immunity: insights from C. elegans bit.ly/3YFbXzi
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Absolutely bursting with C. elegans, @UMassChan , @MGHMolBio , Simches 7 pride this morning!!! Congrats Victor and Gary!!!!
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Pukkila-Worley Lab is also @rpwlab.bsky.social retweeted
Looking for an up to date review on dna sensors and their role in autoinflammatory diseases check out this review from @Mingqi7up 👇
nature.com/articles/s4159…
I hope this is a helpful review!
Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate. Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!
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Welcome Karthik!!!
We are super excited to be welcoming @karthik_varanas to the Division of INnate Immunity @UMassChan this November to start his lab @UMassChanPII ---welcome to @UMassChan @UMassChanGSBS #newPI
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Sharing a nice write-up from @UMassChan highlighting @tse_elegans and her recent companion papers from my lab that were published last week in @ImmunityCP and @CellReports . umassmed.edu/news/news-arch…
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Pukkila-Worley Lab is also @rpwlab.bsky.social retweeted
Online now: Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles dlvr.it/TDP14w
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