In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons.
doi.org/10.1126/scienc…
@JoePetersLab @BarabasGroup
doi.org/10.1126/scienc…
@JoePetersLab @BarabasGroup
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TnsBC telomeric transposons are highly diverse, with distinct gene repertoires. Surprisingly, one subgroup includes the Type I-E Cascade + tnsBC system. The tnsBC was initially thought to replace Cas1-Cas2. Spacer analysis supports their telomeric role, often targeting ttrA.
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With ~1/3 of Streptomyces genomes carrying telomeric transposons, these elements compete for the same niche. Identical transposons in different telomeres, both within and between genomes, are occasionally found to be disrupted by other transposons, indicating fierce competition.
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popo retweeted
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.110…
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popo retweeted
Excited to share our recent findings on Tn7 and its fascinating targeting mechanism, now published in Molecular Cell! 🧬🔬Check it out sciencedirect.com/science/articl…
Happy to share that our last story on Tn7 is finally out. Another example of @shen_yao10 talent and a great collaboration with @JoePetersLab @MikePetassi
Assembly of the Tn7 targeting complex by a regulated stepwise process sciencedirect.com/science/articl…
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popo retweeted
Disclaimer: Photo was digitally edited to include @PopoMicro and @MachadoChacon who couldn't make the photo shot
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It was a pleasure working with @PopoMicro on this review of CRISPR-Cas associated transposons (CAST). Hopefully it gives a sense for the diversity of Tn7-like transposons and CRISPR systems that independently combined.go.shr.lc/444PwFh
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Hats off to the brilliant minds at Feng lab and Gootenberg lab for their awe-inspiring research achievement!
(What a competitive field, people always have manuscripts ready at about the same time)
biorxiv.org/content/10.110…
(What a competitive field, people always have manuscripts ready at about the same time)
biorxiv.org/content/10.110…
Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…
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Our small discovery just got published 😇.
Relatively few cyanobacterial genomes are home to most known families of CRISPR-Cas transposons (CAST). After a careful search, we found a new capture: type I-D CAST~
academic.oup.com/nar/advance-ar…
@JoePetersLab
Relatively few cyanobacterial genomes are home to most known families of CRISPR-Cas transposons (CAST). After a careful search, we found a new capture: type I-D CAST~
academic.oup.com/nar/advance-ar…
@JoePetersLab
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@JoePetersLab We thank Dr. Pietrasiak for providing the strain used in this work from the Terrestrial Cyanobacterial Culture Collection (NuMex TCCC). The frozen cell mass sent by Dr. Pietrasiak was even alive! Tough dessert cyanobacteria! @DrylandAlgae
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popo retweeted
@PopoMicro @JoePetersLab @ShreyaKrishnan3 @MarcinNowotny @kellogg_liz @Nancy_Craig777 @alba_guarne @PhoebeARice @BarabasGroup @Christinahong9 Look what I found!
Compliments of the talented @christinerbeck
Compliments of the talented @christinerbeck
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Happy CSHL transposable meeting! #cshlTE22 @shsternberg @JoePetersLab @ShreyaKrishnan3 @MarcinNowotny @kellogg_liz @Nancy_Craig777 @alba_guarne @PhoebeARice @BarabasGroup @Christinahong9 Dyda lab
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CRISPR 2022~
Popo happy~
Popo happy~
CRISPR 2022 conference was a blast, with lots of exciting new transposon biology! Fitting, to come just before #TransposonDay2022. We didn’t catch everyone for the pic but some key players @JoePetersLab @kellogg_liz @fthoffmann @MikePetassi …
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