Pinned Tweet
Allosteric activation of PRC2 is coupled to adoption of the compact state. Our new bioRxiv manuscript shows that EZH2 S21-phos, adjacent to the SANT1 domain, restrains this conformational transition and limits activation. @vignesh_k757 & Ben Garcia lab tinyurl.com/4369kmh2
0
3
8
683
The Lewis Lab retweeted
Our review on BAF complexes, molecular machines that control which parts of the genome are accessible, is out in @NatureSMB. They’re mutated in 20% of human cancers and are a growing frontier for epigenetic medicine. With @HargreavesLab nature.com/articles/s4159…
0
2
5
210
Our updated study is now published in Genes & Development! We set out to better understand how DAXX assembles H3.3 nucleosomes. This led us to identify separation-of-function mutants that allowed us to disentangle H3.3 deposition from ERV repression.
genesdev.cshlp.org/content/early/…
genesdev.cshlp.org/content/early/…
New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing.
biorxiv.org/content/10.648…
0
8
46
2,178
The Lewis Lab retweeted
Preprint alert!
We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by variants in ASXL1.
This project was led by PhD student @Emma_JDoyle, one of the OG Conway lab members👏. 1/6
biorxiv.org/content/10.648…
We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by variants in ASXL1.
This project was led by PhD student @Emma_JDoyle, one of the OG Conway lab members👏. 1/6
biorxiv.org/content/10.648…
1
1
6
1,240
The Lewis Lab retweeted
Independent of sequence, disordered regions promote the stable chromatin occupancy required for pioneer-factor activity @ScienceAdvances
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
1
6
12
1,502
The Lewis Lab retweeted
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell… @PennMedCSO @PennCancer @PennEpiInst
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.110…
6
16
85
13,100
The Lewis Lab retweeted
📕 Happy to share our review in @NatureRevGenet on the mechanisms that integrate the environment into gene responses.
nature.com/articles/s4157…
@CarolineDeanLab @JohnInnesCentre
#environment #epigenetics #climatechange
nature.com/articles/s4157…
@CarolineDeanLab @JohnInnesCentre
#environment #epigenetics #climatechange
1
12
31
3,440
The Lewis Lab retweeted
🔊 Check out the latest paper titled 𝘚𝘌𝘛𝘋𝟤 𝘮𝘦𝘵𝘩𝘺𝘭𝘵𝘳𝘢𝘯𝘴𝘧𝘦𝘳𝘢𝘴𝘦 𝘢𝘤𝘵𝘪𝘷𝘪𝘵𝘺 𝘱𝘳𝘰𝘮𝘰𝘵𝘦𝘴 𝘤𝘰𝘳𝘳𝘦𝘤𝘵 𝘵𝘳𝘢𝘯𝘴𝘤𝘳𝘪𝘱𝘵𝘪𝘰𝘯 𝘪𝘯𝘪𝘵𝘪𝘢𝘵𝘪𝘰𝘯 𝘢𝘯𝘥 𝘵𝘦𝘳𝘮𝘪𝘯𝘢𝘵𝘪𝘰𝘯, just published in the EMBO Reports @SpringerNature!
📲 y
👩🏻🔬👨🏻🔬 The publication was authored by researchers from the GLaboratory of Genome Regulation (@STOPlabPI) and the Laboratory of Developmental Epigenetics, CAT AMU: Magda Kopczyńska, Agata Stępień, Michał Gdula, and Kinga Kamieniarz-Gdula. 👩🏻🔬👨🏻🔬The remaining authors are Chihiro Nakayama and Prof. Takayuki Nojima from @KyushuUniv_EN in Japan.
📲 y
👩🏻🔬👨🏻🔬 The publication was authored by researchers from the GLaboratory of Genome Regulation (@STOPlabPI) and the Laboratory of Developmental Epigenetics, CAT AMU: Magda Kopczyńska, Agata Stępień, Michał Gdula, and Kinga Kamieniarz-Gdula. 👩🏻🔬👨🏻🔬The remaining authors are Chihiro Nakayama and Prof. Takayuki Nojima from @KyushuUniv_EN in Japan.
0
2
8
375
The Lewis Lab retweeted
Allosteric activation of PRC2 is coupled to adoption of the compact state. Our new bioRxiv manuscript shows that EZH2 S21-phos, adjacent to the SANT1 domain, restrains this conformational transition and limits activation. @vignesh_k757 & Ben Garcia lab tinyurl.com/4369kmh2
0
3
8
683
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @vignesh_k757 & Ben Garcia lab! tinyurl.com/4369kmh2
1
7
44
2,579
In a genome not so far away, the most elegant design in the galaxy was already wrapped into ~147 base pairs. #HappyNucleosomeDay, May-The-Fourth Be With You.
1
20
82
3,573
The Lewis Lab retweeted
Excited to share our latest study in @NatureComms where we uncover a new mechanism of chromatin regulation that is essential in certain SWI/SNF-mutant cancers. Congrats to @HaydenMalone3 and coauthors! #SWISNF #cancer (1/8)
@StJudeResearch @stjudegraduate
nature.com/articles/s4146…
@StJudeResearch @stjudegraduate
nature.com/articles/s4146…
2
14
36
4,223
The Lewis Lab retweeted
Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with DeLuca lab!
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
Microtubules have been viewed as passive structural supports, but a study from @HironoriFunabi1 in @ScienceAdvances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer.
🔗: bit.ly/4v8miCC
2
7
26
4,286
The Lewis Lab retweeted
Our latest research is now out in @NatureCellBio nature.com/articles/s4155…
We show that nonsense-mediated mRNA decay (NMD) pathway safeguards #telomere integrity in pluripotent #stemcells
We show that nonsense-mediated mRNA decay (NMD) pathway safeguards #telomere integrity in pluripotent #stemcells
2
8
15
1,444
The Lewis Lab retweeted
A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development | Nature Communications nature.com/articles/s4146…
0
3
10
879
The Lewis Lab retweeted
Preprint: The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
researchsquare.com/article/rs-867… @UCLA
researchsquare.com/article/rs-867… @UCLA
0
6
37
2,607
The Lewis Lab retweeted
Our linker histone H1 paper is out @ScienceAdvances: science.org/doi/10.1126/sc…
@MasaAShimazoe et al. reveal that H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo, @janhuemar, Charlie Phillips and others—huge thanks! 🙌 ½
@MasaAShimazoe et al. reveal that H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo, @janhuemar, Charlie Phillips and others—huge thanks! 🙌 ½
5
72
309
37,260
The Lewis Lab retweeted
How to make a heterochromatin by major satellite repeats transcripts?
Congrat @AleciaYHLO and Thomas Jenuwein lab for the work.
nature.com/articles/s4146…
Congrat @AleciaYHLO and Thomas Jenuwein lab for the work.
nature.com/articles/s4146…
1
4
10
1,371
The Lewis Lab retweeted
Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q
Edwina McGlinn & Chen Davidovich in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
Edwina McGlinn & Chen Davidovich in Mol Cell
#Epigenetics #PRC2 #H3K27me3
---
Perfect for cancer, immunology, and aging; epigenometech.com
0
5
20
939