Will Bailis @metaBailism trying to figure out the inner works of our beloved mentor Richard Flavell @FlavellLab using two exceptionally handsome scientists
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Roni Nowarski retweeted
Speakers from @BrighamWomens/@harvardmed, @cwru, @cinvestav will provide insights into various aspects of innate and adoptive #immunity in #inflammation. Check out the full #Pathobiology2025 program bit.ly/3yOeuxu
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Imagine there's no treatment
It's easy if you see
Nothing to fight your cancer
Or autoimmunity
Imagine all the research
Ceasing to exist
Woo-hoo hoooo
It's easy if you see
Nothing to fight your cancer
Or autoimmunity
Imagine all the research
Ceasing to exist
Woo-hoo hoooo
Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”?
What a ripoff!
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A terrific synopsis of bistability in innate immune signaling by Jayajit Das and Giuseppe Giuliani, previewing our paper on macrophage tolerogenic memory published today @immunity cell.com/immunity/abstr…
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A Cellular Atlas of Gut Inflammation the-scientist.com/a-cellular-atl…
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Roni Nowarski retweeted
Our new work published today @NatrureMedicine nature.com/articles/s4159…
The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann).
Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann).
Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
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Roni Nowarski retweeted
Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.
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Roni Nowarski retweeted
New research from @NowarskiLab uncovers a 'switch' in the gut that can provide protection against harmful intestinal inflammation. The work was published in @ImmunityCP buff.ly/3z8n35V
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Roni Nowarski retweeted
@ImmunityCP A must read for anyone interested in how innate immune signals impact intestinal inflammation.
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Very excited to share our paper showing that IL-18 activation of the salt transporter NCC programs durable immune tolerance in the gut! We found that NCC induces a metabolic switch in macrophages that stabilizes fatty acid oxidation and prevents glycolytic reprogramming ⬇️
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This tolerogenic state is maintained and reinforced in macrophages by a bistable circuit driven by cGAS-STING activation, and by an intercellular positive feedback loop sustaining epithelial IL-18 and macrophage cGAMP secretion.
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Incredibly proud of Tyler Mertens, Aditya Misra @amisra96, Peng Xiao and the team for figuring it out! Big thanks to @FlavellLab, @m_hemberg, @KanarekNaama and @AnaAndersonlab!
Read more here @ImmunityCP: authors.elsevier.com/a/1jICr3qNrUxt…
Read more here @ImmunityCP: authors.elsevier.com/a/1jICr3qNrUxt…
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Thrilled to have our work mapping tissue remodeling in intestinal inflammation online! An amazing collaboration between @SivanathanKisha and Paolo and Jeff in the @MoffittLab probing the diversity and origin of #inflammation associated #fibroblasts. doi.org/10.1016/j.cell…
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Roni Nowarski retweeted
If you don't live in Israel or consume Israeli media, you don't know who Yair Golan is. He is a 61-year-old retired Major General in the Israel army and a former parliament MP. Spend a minute to read this story.
Yesterday, when IDF and the police were in complete chaos, Golan took his weapon, and drove into the war zone multiple times to rescue civilians under fire. He rescued two young adults hiding under a bush after 260 of their friends were murdered at an outdoor party. He answered a call from a journalist that his son was hiding under fire and simply said, "Give me his location, and I will bring him back home." An hour later, the son called his father from Golan's car.
Golan collected a small crew and went in and out of the war zone, rescuing dozens of people while exchanging fire with Hamas terrorists. He is 61, he could have stayed home, but he chose to risk his life for people he does not know.
Golan is one of the strongest voices from the Israeli left and was constantly attacked by the right wing in Israel. But when the time came, he was first fighting the barbaric attack. The same brain wiring that supports peace, is often the same wiring that drives people to do the right thing.
A true hero.
Yesterday, when IDF and the police were in complete chaos, Golan took his weapon, and drove into the war zone multiple times to rescue civilians under fire. He rescued two young adults hiding under a bush after 260 of their friends were murdered at an outdoor party. He answered a call from a journalist that his son was hiding under fire and simply said, "Give me his location, and I will bring him back home." An hour later, the son called his father from Golan's car.
Golan collected a small crew and went in and out of the war zone, rescuing dozens of people while exchanging fire with Hamas terrorists. He is 61, he could have stayed home, but he chose to risk his life for people he does not know.
Golan is one of the strongest voices from the Israeli left and was constantly attacked by the right wing in Israel. But when the time came, he was first fighting the barbaric attack. The same brain wiring that supports peace, is often the same wiring that drives people to do the right thing.
A true hero.
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So proud of Aditya Misra @amisra96 for being selected as a @MathWorks Engineering Fellow in recognition of "outstanding academic record, exceptional background, and promising future". Keep at it Rockstar!
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Roni Nowarski retweeted
The most beautiful spatial paper I have seen, a notch (or two) above all the rest. Congratulations to the team.
#Colitis is a complex form of #IBD & #MERFISH #SpatialTranscriptomics can be used to study it! Researchers led by Dr. Jeff Moffitt from @BostonChildrens developed a framework for studying inflammation-induced #GutRemodleing in mice.🐭
Read the preprint: hubs.ly/Q01QnTX70
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Excited to announce the results of an exciting collaboration with Jeff Moffitt and @MoffittLab at @harvardmed, where we charted the cellular organization of the #gut and show how #inflammation shapes fibroblast trajectories and tissue remodeling!
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
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