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🚨Preprint alert!
STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs
▪️ Done in 1 week with ~100% efficiency
▪️ Markerless and near-scarless approach performed in >10days in a single-well
▪️ Carrying not one but two (single-copy) payloads
See🧵below!
STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs
▪️ Done in 1 week with ~100% efficiency
▪️ Markerless and near-scarless approach performed in >10days in a single-well
▪️ Carrying not one but two (single-copy) payloads
See🧵below!
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly?
🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n)
Link: biorxiv.org/content/10.110…
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Mummery Lab retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
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Mummery Lab retweeted
Our STRAIGHT-IN Dual platform is officially out at @natBME 🔥🚀
A big step forward for programmable stem cell engineering — faster, cleaner, and more versatile.
Link📰: nature.com/articles/s4155…
Don’t miss the 🧵 from the one and only @GallowayLabMIT breaking it all down 👇
A big step forward for programmable stem cell engineering — faster, cleaner, and more versatile.
Link📰: nature.com/articles/s4155…
Don’t miss the 🧵 from the one and only @GallowayLabMIT breaking it all down 👇
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵
Link at end!
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Mummery Lab retweeted
🚨We have updated our STRAIGHT-IN Dual preprint!
🧵with all the details in the comments (1/n)
Link: biorxiv.org/content/10.110…
@GallowayLabMIT @nbwang22 @BenBlakeleyJ @annionna
🧵with all the details in the comments (1/n)
Link: biorxiv.org/content/10.110…
@GallowayLabMIT @nbwang22 @BenBlakeleyJ @annionna
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly?
🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n)
Link: biorxiv.org/content/10.110…
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Mummery Lab retweeted
Cells transit through a quiescent-like state to convert to neurons at high rates biorxiv.org/cgi/content/sh… #biorxiv_sysbio
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Mummery Lab retweeted
New career goal unlocked:
✅ Attending the #SynBio24 conference with my twin brother @marcblanch94.
Thanks @GallowayLabMIT @billerbeck_s @ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️
biorxiv.org/content/10.110…
✅ Attending the #SynBio24 conference with my twin brother @marcblanch94.
Thanks @GallowayLabMIT @billerbeck_s @ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️
biorxiv.org/content/10.110…
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Mummery Lab retweeted
What characteristics should an MPS have to be useful for modeling human phenotypes?
In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings.
nature.com/articles/s4155…
In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings.
nature.com/articles/s4155…
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Mummery Lab retweeted
Super thrilled to be part of the reNEW #ARTxSCIENCE competition! Choose your favorite image (obviously mine 😉) showing some exciting new work happening with another postdoc and myself! renew.science/artxscience/#a…
#LUMC @MummeryLab #cardioid #confocal #stemcell
#cardiac
#LUMC @MummeryLab #cardioid #confocal #stemcell
#cardiac
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Mummery Lab retweeted
Extremely happy to see the protocol manuscript for the STRAIGHT-IN platform out online and featured as protocol of the week @NatureProtocols.
#FeaturedProtocol this week is for STRAIGHT-IN: a platform for rapidly generating panels of #geneticallymodified #humanpluripotentstemcell lines bit.ly/3yJXlVP @A_BlanchAsensio
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Mummery Lab retweeted
Join Professor Christine Mummery (@MummeryLab), #reNEW Leiden @LUMC_Leiden, for a panel discussion at #ISSCR2024 on 'Use of Standards for Stem Cells in Non-Clinical Research' on Fri 12 July, 1.30pm-3.00pm CEST in Hall G2, Level 2.
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Happy to see our work highlighted at The Scientist magazine.
Targeted Gene Integration for High-Throughput Applications
the-scientist.com/targeted-gene-…
Targeted Gene Integration for High-Throughput Applications
the-scientist.com/targeted-gene-…
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Mummery Lab retweeted
Kicking off the last session of Day 1 #ISSCRCincy is @MummeryLab with a fantastic update on her work on hpsc-derived cardiovascular tissue to study disease. @ISSCR
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We are pushing stem cell research further than ever before. Meet Professor Christine Mummery. Her work focuses on understanding cardiovascular development and disease mechanisms.
All reNEW researchers are leaders within their field, with a strong track record of scientific hey work to turn their research into real therapies that improve the health of people around the world.
See full video: renew.science/principal_inve…
@GlobalLumc @MummeryLab @MCRI_for_kids @UCPH_Research #stemcellresearch #stemcelltherapies #cardiovasculardevelopment
All reNEW researchers are leaders within their field, with a strong track record of scientific hey work to turn their research into real therapies that improve the health of people around the world.
See full video: renew.science/principal_inve…
@GlobalLumc @MummeryLab @MCRI_for_kids @UCPH_Research #stemcellresearch #stemcelltherapies #cardiovasculardevelopment
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Mummery Lab retweeted
Congratulations to postdoc Ben Johnson, from the Richard Davis and @MummeryLab at reNEW Leiden for receiving a prestigious Marie Curie fellowship. Ben will use the fellowship to develop a stem cell based model for myocardial infarctions. Read more:
renew.science/stories/marie-…
renew.science/stories/marie-…
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Mummery Lab retweeted
Delighted to welcome Albert Blanch Asensio @A_BlanchAsensio as a visiting student with our lab! Albert pioneered STRAIGHT-IN with Richard Davis and @MummeryLab. We're excited to build circuits in these landing pad iPSC lines!
tinyurl.com/snhjesjw
tinyurl.com/snhjesjw
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🧐 #MeetTheSpeaker!
🔬 @MummeryLab @LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine.
youtu.be/a13QH7CM-pc
🔬 @MummeryLab @LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine.
youtu.be/a13QH7CM-pc
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Mummery Lab retweeted
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes dlvr.it/T18sgJ
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Mummery Lab retweeted
Thrilled to be awarded the NWO-XS grant to generate an inducible heart attack stem cell model in a fantastic lab! @MummeryLab @reNEW_Global linkedin.com/posts/novo-nor…
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The true #vascular meets #cardiac: it's going to be an awesome conference! Looking forward to it.
Mark your calendars!🗓️
#Cardiovascular
@UofT_LMP @bme_uoft @UHN_Research @TGHRI_UHN @vascularbiology
Mark your calendars!🗓️
#Cardiovascular
@UofT_LMP @bme_uoft @UHN_Research @TGHRI_UHN @vascularbiology
Join the new EMBO Workshop 'The new cardiobiology' and deepen your understanding of the causes and early development of cardiovascular disease.🫀
📩 Submit abstract by 28 November ➡️ s.embl.org/ncb24-01 #EMBOCardioBiology
#EMBOCardioBiology
Scientific organisers are: @PilarAlcaidePhD, @JohannesBacks, @TinaHaase3 and @PorrelloER.
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