Please join us in welcoming Dr. Paul Macklin @MathCancer to @michiganstateu, w/ joint appointments in @MSU_Medicine & Biomedical Engineering. A world leader in computational medicine, including development of “digital twins” to predict individualized treatment outcomes, he serves as tg Research Professor, Center Director for Computational Modeling in Oncology, Chief of the Division of Computational Medicine in the Department of Medicine at @MSUMD. He also serves as the Director of Digital Health Research at @devoschildrens of @CorewellHealth.

@astrocatinfo Thanks! Alas not a dual--just the one Tak.

@astrocatinfo Looks really nice, Aleix!

I'm setting up my Tak-Epsilon 180ed right now, and hope to give it a shot on a comet. f/2.8 hopefully will work for getting some tail details!

Any advice?

@FritzdKat @McDonalds That was fast! Amazed you got in to even see that result!

I was at error 429 even at 10:59 am

Background:

usatoday.com/story/money/fo…

(Same error on Xfinity and Verizon 5G, for the record.)

Yep, this is pretty much how I figured the 11 am caviar promo would turn out at @McDonalds

@Magnetodawn Happy 2026 to you!

Please LMK if you do find yourself on BlueSky. (I'm there under same username.)

Waited in a 90-minute line in the rain to get one last Sprinkles Cupcake before all of the stores shut down forever.

Corporate America delivering one last shitty moment to ring out a very shitty year.

Fuck 2025 and fuck private equity.

Thrilled to see our project on the cover of this week's @ScienceMagazine. Incredibly fun and rewarding collab with the public, @eliz_aguilar2 @JuncoWren @imillercrews @MathCancer

Epic indeed, @JoshuaABull !

This week in Math Onco 345:

Darwinian evolution, digital twins, multiscale modeling, and antifragility

Art: @MathCancer & Heber L Rocha 😎💯

In a serious case of a weirdly small world, I ran into @Seirin_Lab at @OxUniMaths in the visitor office.

What a joy!

@FabianSpill Thanks, Fabian! and was great to see you at SMB!!!

@SKabrajiMD @JKTGFoundation @BCRFcure @theNCI @NIH @PhysiCell And we're just getting started!

We are now working to make it easier to load, export, share, and recombine models written in the grammar, and next-generation extensions of the language.

Also working with other open source leaders to support the grammar for model exchange

@SKabrajiMD @JKTGFoundation @BCRFcure @theNCI @NIH Thank you!

Yes, the grammar is already fully incorporated in @PhysiCell, and you can try it yourself with web-based PhysiCell Studio. Please do!!

I suggest a recent short course we taught last week that gives a taste! :-)

github.com/physicell-trai…

And we're beyond grateful for early support by the @JKTGFoundation (and even earlier by @BCRFcure) and @theNCI and @NIH. Without early support for basic sciences, we would never have been in the position to create this work today! 17/17

It was a great honor to work with this team. We have accomplished something beautiful together we could never have done on our own. It is an honor to count them as colleagues and friends! 16/n

Elana did a beautiful job describing the paper on LinkedIn. Give that a read too, please! 15/n

linkedin.com/feed/update/ur…

You may notice that these examples are 2D. We used 2D to rapidly iterate development of each of these models, but the grammar is tied to cell behaviors, not 2D or 3D. We were able to rapidly convert a 2D tumor-immune model to 3D, with ZERO changes to the model rules! 14/n

And in work led by Genevieve Stein-O'Brien (@GenesOfEve) and her team, she showed that the grammar isn't just limited to cancer or even cancer immunology. They built a model with @AllenCellInst brain atlas data, and modeled neurocortex development! 13/n