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So happy to finally share this work! Thank you @AnnaVarghese4 @chaiband @EileenMOReilly @MFBerger1 @nikolausschultz for all of your guidance & insight 🧬 Research Briefing: doi.org/10.1038/s41591…
Excited to share our latest in @NatureMedicine✨
We present a detailed clinico-genomic landscape of pancreatic adenocarcinomas
With important implications for RAS 🎯 therapies
Expertly co-led by @AnnaVarghese4 and @MariaAPerry. w/@EileenMOReilly & colleagues
@MSKCancerCenter
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Maria A Perry retweeted
Featured today by @MSKLibrary: Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer
#BiallelicInactivation #TumorSuppressorGenes
#LungCancer #CancerBiomarkers #KEAP1 #PrecisionOncology
lkrief @AntonSafonovMD @rohit_thum @MeelisXY @CDebyaniPhD @ARoseBrannon @MLadanyi @PedramRazaviMD @YoninaMG @KristianaGrigo4 @NickyMcGranahan @CharlesSwanton @ronglais
dx.doi.org/10.1016/j.cell…
#BiallelicInactivation #TumorSuppressorGenes
#LungCancer #CancerBiomarkers #KEAP1 #PrecisionOncology
lkrief @AntonSafonovMD @rohit_thum @MeelisXY @CDebyaniPhD @ARoseBrannon @MLadanyi @PedramRazaviMD @YoninaMG @KristianaGrigo4 @NickyMcGranahan @CharlesSwanton @ronglais
dx.doi.org/10.1016/j.cell…
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Maria A Perry retweeted
That KRAS Wild type #PancreaticCancer is a distinct entity from KRAS mutant disease was also recently reported by @EileenMOReilly & colleagues in their single institution study from @MSKCancerCenter in @NatureMedicine
nature.com/articles/s4159…
nature.com/articles/s4159…
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Maria A Perry retweeted
Increased KRAS mutant allele dosage is an important negative prognostic feature that will need to be integrated into clinical practice as we move into the era of 🎯 RAS-directed therapeutics for PDAC.
🔸️
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS stic of overall survival
🔸️
doi.org/10.1038/s41591…
🔸️
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS stic of overall survival
🔸️
doi.org/10.1038/s41591…
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Maria A Perry retweeted
🧬KRAS mutations in pancreatic cancer
@NatureMedicine
🚨95% of pancreatic cancers are KRAS mutant
❗️KRAS mut-allele dosage 🔺,OS🔻
⁉️Targetting KRAS!
👉doi.org/10.1038/s41591…
@EileenMOReilly @OlcaBasturk @OncoAlert @realbowtiedoc @ArndtVogel #cancer #oncology #MedX
@NatureMedicine
🚨95% of pancreatic cancers are KRAS mutant
❗️KRAS mut-allele dosage 🔺,OS🔻
⁉️Targetting KRAS!
👉doi.org/10.1038/s41591…
@EileenMOReilly @OlcaBasturk @OncoAlert @realbowtiedoc @ArndtVogel #cancer #oncology #MedX
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Maria A Perry retweeted
Paper: nature.com/articles/s4159…
Data for 2,336 patients with PDAC on cBioPortal: cbioportal.org/study/summary?…
@MSKPathology @CpcrMsk @MSK_DeptOfMed
Data for 2,336 patients with PDAC on cBioPortal: cbioportal.org/study/summary?…
@MSKPathology @CpcrMsk @MSK_DeptOfMed
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Maria A Perry retweeted
Excited to share our latest in @NatureMedicine✨
We present a detailed clinico-genomic landscape of pancreatic adenocarcinomas
With important implications for RAS 🎯 therapies
Expertly co-led by @AnnaVarghese4 and @MariaAPerry. w/@EileenMOReilly & colleagues
@MSKCancerCenter
We present a detailed clinico-genomic landscape of pancreatic adenocarcinomas
With important implications for RAS 🎯 therapies
Expertly co-led by @AnnaVarghese4 and @MariaAPerry. w/@EileenMOReilly & colleagues
@MSKCancerCenter
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Maria A Perry retweeted
Thrilled to share our recent work in @CellCellPress ✨
We study the extent to which tumor suppressor genes in cancer adhere to Knudson's ‘two-hit’ hypothesis, and their clinical implications. 🧵👇
Also a detailed 🧵 by @EdReznik below:
@MSKPathology @MSKCancerCenter
We study the extent to which tumor suppressor genes in cancer adhere to Knudson's ‘two-hit’ hypothesis, and their clinical implications. 🧵👇
Also a detailed 🧵 by @EdReznik below:
@MSKPathology @MSKCancerCenter
A culmination of ~5 years of work, today our work on biallelic alterations across tumor suppressor genes is published in @CellCellPress. With Mark Zucker, Maria Perry, and Chai Bandlamudi cell.com/cell/fulltext/…
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Maria A Perry retweeted
At #AACR23 the coming days with lots of folks from @nikolausschultz's lab! Come say hi! Find us at the @cbioportal and @OncoKB booths most days. Feel free to DM if u want to meet up
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Maria A Perry retweeted
If you missed #WCM's COVID-19 vaccine ambassador training, the full session is now live on our YouTube channel!
Help your loved ones make an informed decision about getting vaccinated. bit.ly/3ogRTOK
Help your loved ones make an informed decision about getting vaccinated. bit.ly/3ogRTOK
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Maria A Perry retweeted
Sharing my simple talking points for people who are hesitant to get #CovidVaccine because they fear vaccine creation was rushed.
🧵
🧵
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Maria A Perry retweeted
Curious about COVID-19 vaccines? Tune in tomorrow to hear @KizzyPhD's talk at 11:30am ET. Livestreaming details: bit.ly/700Covid
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!
Pfizer’s Covid-19 Vaccine Proves 90% Effective in Latest Trials
wsj.com/articles/covid…
SCIENCE WINS!!! This is GREAT news for mRNA technology, AWESOME for the stabilized prefusion spike antigen.
I am in tears.
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