Cells, who needs them? Fun to be in @Nature.com’s technology feature with @MichaelCJewett , @thenoireauxlab, @HNiederho, Wilson Wong, @LucksLab, Evan Karousis, Yan Zhang, Emily Chen & @cynbio01 🧪
nature.com/articles/d4158…

Jiami and Laura's paper is out now! In collaboration with the Reddy lab at ETHZ!

cell.com/cell-systems/f…

We combined cell-free protein synthesis + microfluidics to rapidly map how SARS-CoV-2 mutations affect antibody binding — 518 RBD variants, ~31,700 affinity measurements, 3 binding-energy landscapes spanning WT to Omicron.

Pao-Wan and co's paper is published now as well !

"A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications"

nature.com/articles/s4146…

Saeed's paper is now published:

"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins"

nature.com/articles/s4146…

Maria's paper on characterizing trans-properties of transcription factors and how they affect gene expression is out now!

biorxiv.org/content/10.648…

Saeed's latest paper is now out on bioRxiv:

"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins"

biorxiv.org/content/10.648…

Check out Amogh's latest review:

"Microfluidics meets cell-free systems: from molecular engineering to synthetic cells"

now published in Current Opinion in Biotechnology.

sciencedirect.com/science/articl…

Laura and Jiami's paper is out now on BioRxiv! Nice collaboration with the Reddy lab at ETHZ:

"High-throughput cell-free profiling of SARS-CoV-2 RBD variants enables rapid and quantitative in vitro affinity landscape mapping."

biorxiv.org/content/10.110…

The Maerkl Lab is now on Bluesky (better late than never as they say...)!
bsky.app/profile/maerkl…

Fanjun and Amogh's paper is now published:

"Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system"

nature.com/articles/s4146…

Pao-Wan, Saeed and Matthis' paper is out now on BioRxiv:

"A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications"

biorxiv.org/content/10.110…

Fanjun and Amogh's paper is out now on BioRxiv:

"Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system."

biorxiv.org/content/10.110…

Laura and Laura's paper is out now in ACS Synthetic Biology.

"Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System"

pubs.acs.org/doi/full/10.10…

Pao-Wan's review on cell-free regulatory components is out now!

Regulatory Components for Bacterial Cell-Free Systems Engineering | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…

Laura (@SuNMIL_EPFL) and Laura's paper on running the PURE system for weeks using a simple mesoscale dialysis system is now on bioRxiv!!

"Long-term protein synthesis with PURE in a mesoscale dialysis system"
biorxiv.org/content/10.110…

The Maerkl Lab is hiring one or two graduate students to work in the area of cell-free synthetic biology, specifically synthetic cell engineering! Deadline for our EDBB doctoral program is Nov 1st ...

See below for more information:
eth-gethired.ch/de/jobs/detail…

Ragu's paper is now officially out in ACS SynBio:

Towards Self-regeneration: Exploring the Limits of Protein Synthesis in the Protein Synthesis Using Recombinant Elements (PURE) Cell-free Transcription–Translation System | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…

Laura's paper from the Stellacci lab (@frstella) is out now:
Nature-Inspired Recycling of a Protein Mixture into a Green Fluorescent Protein-based hydrogel - now published in RSC Sustainability
pubs.rsc.org/en/content/art…

Amogh's comprehensive review of microfluidic approaches and applications in cell-free synthetic biology is out now!

#microfluidics #cellfreesynbio #synbio #syntheticbiology

frontiersin.org/articles/10.33…