This modular lentiviral platform enables multiplexed gene perturbation and tracking in vivo, revealing distinct hormone receptor dependencies in breast cancer and additive growth suppression while reducing animal use. @ReviewCommons
hubs.la/Q04DyNNd0

Unsupervised explainable AI identifies ~2,000 oligonucleotide-usage zones in the human genome and predicts high-resolution chromosome banding from genome sequences, bridging genomics and cytogenetics. @nbio8100_kouhou
hubs.la/Q04DyMtb0

B-cell synapse formation boosts mitochondrial spare capacity. This requires microtubule stabilization and mitochondrial reorganization, both mediated by EFhd2-linking BCR signaling to cytoskeletal and metabolic adaptation. #BCR #Mitochondria #Microtubules hubs.la/Q04Dp6mL0

🧬 This study explores how SNORD116 affects DGKK expression and RNA modifications, offering insights into Prader-Willi syndrome.
@Columbia
hubs.la/Q04Dp68C0

Evolutionarily young transposable elements in mouse are a source of placenta-specific gene regulatory elements that generate high inter-species diversity, potentially fuelling fast placental evolution.
@ReviewCommons
hubs.la/Q04Dp5nP0

The RNA-binding domain of the human GEMIN5 protein consists of an oligomerizing extended surface, including a serine-rich motif and a disordered acidic cluster that cooperatively regulate RNA binding. @emarsal2 @CBM_CSIC_UAM
hubs.la/Q04Cz9wj0

In our November issue: An epigenetic signature predicts relapse in pediatric leukemia, how EGFR signaling fine-tunes intestinal progenitor cell growth, and a unique role for IL-1 signaling in pancreatic islets. 
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Microtubules coordinate cellularization in a coenocytic relative of animals @ReviewCommons
hubs.la/Q04Crs7N0

“We would not hesitate to recommend LSA to a colleague and look forward to submitting our future work here as well.”—Diana P. Bratu. Publish in LSA, a network that works for you. hubs.la/Q04xwNRw0

Read Dr. Bratu and colleagues’ article in LSA today, “Bruno 1 remodels P-bodies to protect select mRNAs during the early ER stress response” life-science-alliance.org/content/9/10/e…

GEMIN5 requires proper tertiary structure to bind its RNA targets. Pathogenic C-terminal mutations linked to neurodevelopmental disorders may disrupt RNA binding.
@emarsal2 @CBM_CSIC_UAM
hubs.la/Q04Cz6px0

This Commentary traces how failures along the data-information-knowledge-wisdom hierarchy mislead biomedical research and argues that rigor and falsification must govern human and machine judgment.
#DIKW #AI
@dokhlab @MedicineUVA
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MT networks position cellularization furrows to accurately partition multinucleate S. arctica. U-ExM, perturbations and live imaging suggest shared patterns of cytoskeletal remodelling in eukaryotes. @ReviewCommons
hubs.ly/Q04Cr3BL0

🧬 How is chromatin information translated into developmental decisions?

Interpretation of H3K4me3 is essential for establishing embryonic patterning in Arabidopsis, linking chromatin state to key developmental decisions.

New research in @LSAjournal hubs.la/Q04Bnlrr0

SARS-CoV-2 Nucleocapsid promotes recruitment of IRF & AP-1 transcription factors 🧬, RNA polymerase II, and eEF1A1 to pro-inflammatory gene promoters, revealing a previously unrecognized nuclear role for eEF1A1
@IGBMC👇
hubs.la/Q04BfHf20

Take a look at this recently published paper in LSA:
Esc2 and Rad57 contribute to RNA polymerase II distribution at highly transcribed genes👇
hubs.la/Q04B5ClC0

Gut microbiota and their metabolites shape MASLD progression by modulating intestinal barrier integrity, inflammation, metabolism, and liver signaling.
@IIMCB_Poland
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More data ≠ more understanding. Commentary in Life Science Alliance maps where biomedical research breaks down along the data-information-knowledge-wisdom hierarchy & why scientists & AI alike must stay open to being wrong. #DIKW #AI @dokhlab @MedicineUVA hubs.la/Q04BH-9v0

PK2 is essential for Plasmodium berghei transmission. Its depletion impairs ookinete motility, disrupts microneme organisation, blocks oocyst and sporozoite development, and alters invasion-related phosphorylation. @ReviewCommons
hubs.la/Q04zPBg40

The study shows that interpretation of H3K4me3 is essential for translating chromatin information into the developmental decisions that establish embryonic patterning in Arabidopsis. life-science-alliance.org/content/10/1/e…