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#Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

2024 Top-Read Article in #ACSMedChemLett: Balanced Permeability Index: A Multiparameter Index for Improved In Vitro Permeability
Can one simple metric help guide permeability optimisation? doi.org/10.1021/acsmed… @ACSPublications #KellyChibale

2024 Top-Read Article in #ACSMedChemLett: Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists
Exploring new serotonergic chemical space: doi.org/10.1021/acsmed… @ACSPublications #KellyChibale

2024 Top-Read Article in #ACSMedChemLett: Heteroaryl Glutarimides and Dihydrouracils as Cereblon Ligand Scaffolds for Molecular Glue Degrader Discovery
Expanding the molecular glue toolbox: doi.org/10.1021/acsmed… @ACSPublications #KellyChibale

2024 Top-Read Article in #ACSMedChemLett: Chiral Switches of Tramadol Hydrochloride, a Potential Psychedelic Drug - Past and Future
doi.org/10.1021/acsmed… @ACSBioMed

Our editors are catalysts for scientific progress as active researchers at top institutions. With expertise and global reach, they champion original research that shapes the future.

Join a community committed to advancing science and submit today: go.acs.org/ezq

In the July Issue of #ACSMedChemLett Elena De Vita describes three must read articles.

go.acs.org/eqN

In #ACSMedChemLett, Kim et al. report a modified version of an existing drug (nitazoxanide) that shows promise against hepatitis B. 1 compound worked better than the original & showed good oral absorption, stability & efficacy in animal studies: pubs.acs.org/doi/10.1021/ac… @ACSBioMed

Clofibric acid has been repurposed as a new “guiding tag” for a cutting-edge drug strategy that destroys harmful proteins, opening a new route for designing smarter cancer and disease treatments: pubs.acs.org/doi/10.1021/ac… #ACSMedChemLett @ACSBioMed

The June Issue of #ACSMedChemLett is out today! Sara Goldstein describes three must read articles this month In this Issue:

go.acs.org/ejs

#ACSMedChemLett reports a greener, simpler way to make a new molecules that may fight bacteria. In early tests, bacteria did not develop resistance to one compound after many repeated exposures. @ACSBioMed pubs.acs.org/doi/10.1021/ac…

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa!

📍 @UCT_news
📅 10-11 September

Submit your abstract before 10 June 2026. 

🔗 Apply today:  go.acs.org/eh5

Announcing Call for Papers for Special Issue on Allosteric Modulators in Drug Discovery. pubs.acs.org/doi/10.1021/ac…

Don't forget to register for our upcoming webinar,
where winners of the 2026 Portoghese Lectureship Award will be discussing 'Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’.

📅 June 3, 12:00PM EDT

Register to attend: go.acs.org/eg0

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa!

📍 @UCT_news
📅 10-11 September

Submit your abstract before 10 June 2026. 

🔗 Apply today:  go.acs.org/efU

My latest essay reflects on how AI can strengthen African drug discovery and development ecosystems, from research and clinical trials to scientific capacity and locally relevant innovation.

amacad.org/publication/da…

#KellyChibale #AI #DrugDiscovery #AfricaScience #GlobalHealth

On #AfricaDay, I reflect on how surviving malaria as a child in Zambia shaped my life’s work in science and drug discovery.

Read more: linkedin.com/posts/kelly-ch…

#KellyChibale #AfricaScience #GlobalHealth #MalariaResearch

It also reminded me that behind every medicine are years of research, collaboration, investment and volunteers who participate in clinical trials for the benefit of others.

Scientists are designing smarter cancer drugs that target tumour cells while sparing healthy ones. A new class of molecules developed by Ipatova et al. showed activity against breast cancer cells with less harm to normal cells: pubs.acs.org/doi/10.1021/ac… @ACSPublications

Researchers have discovered a promising new way to treat pain without opioids. By targeting a specific “pain signal” channel (NaV1.8), Dialer et al. developed compounds that are more selective, longer-lasting and potentially safer: pubs.acs.org/doi/10.1021/ac… @ACSPublications

Scientists are getting a clearer picture of how diabetes and weight-loss drugs work. By watching receptors on cells in real time, they found that drugs “grab on” in two ways, helping to explain why some treatments work better than others: pubs.acs.org/doi/10.1021/ac… @ACSPublications