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You know what’s kinda cooler than the brain? Space!
My photography attempts at the Orion Nebula over the past couple years.
My photography attempts at the Orion Nebula over the past couple years.
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Most fun thing I did to improve my weeks in 2025 → nurture relationships in 60 seconds
Try this:
- Text 1 person: for example “was thinking of you, how’s your day going?”
- Do 1 small, kind thing for someone in your community.
- Audio-transcribe how it made you feel in under 20 seconds.
Read your notes at the end of the week. Watch what happens.
Try this:
- Text 1 person: for example “was thinking of you, how’s your day going?”
- Do 1 small, kind thing for someone in your community.
- Audio-transcribe how it made you feel in under 20 seconds.
Read your notes at the end of the week. Watch what happens.
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This, of course, is just the minimum. If a long conversation happens or a hangout gets planned = cherry on top.
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Neuroplasticity = the brain’s ability to change.
But plasticity itself isn't “good” or “bad.”
In a bad environment:
• High plasticity → rapid learning of the wrong lessons
• Low plasticity → can't unlearn them
Here's how to unlock your plasticity 🧵
But plasticity itself isn't “good” or “bad.”
In a bad environment:
• High plasticity → rapid learning of the wrong lessons
• Low plasticity → can't unlearn them
Here's how to unlock your plasticity 🧵
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8/ Plasticity is not inherently positive.
• It’s the brain’s capacity to rewire = toward healing or dysfunction.
• To recover, you must first increase plasticity.
• But change only sticks if the environment supports it.
What you grow depends on your soil.
• It’s the brain’s capacity to rewire = toward healing or dysfunction.
• To recover, you must first increase plasticity.
• But change only sticks if the environment supports it.
What you grow depends on your soil.
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Keith Sakata, MD retweeted
🚨 The older the sperm, the more likely it is to cause autism
Sequencing sperm using nearly error-free sequencing → measure % sperm carrying disease-causing mutations:
2% at age 30 → 4.5% at 70
Most were autism genes
New paper in @Nature today 🧵
Sequencing sperm using nearly error-free sequencing → measure % sperm carrying disease-causing mutations:
2% at age 30 → 4.5% at 70
Most were autism genes
New paper in @Nature today 🧵
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The most brilliant way to change your life (order matters):
1. Decide that you never want to feel/do X ever again.
2. Then, take full accountability for changing it.
3. Put a trusted friend/therapist in your corner.
Self-love = no longer accepting a life you are unhappy with.
1. Decide that you never want to feel/do X ever again.
2. Then, take full accountability for changing it.
3. Put a trusted friend/therapist in your corner.
Self-love = no longer accepting a life you are unhappy with.
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Your future child’s brain is shaped by your age.
Men’s sperm stem cells divide every 15 days. And more divisions = more copy errors. At 40, you pass on nearly 2x the DNA mutations vs age 20.
Autism, bipolar, schizophrenia.
Delaying kids = a biological gamble.
Men’s sperm stem cells divide every 15 days. And more divisions = more copy errors. At 40, you pass on nearly 2x the DNA mutations vs age 20.
Autism, bipolar, schizophrenia.
Delaying kids = a biological gamble.
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This is circadian biology 101.
Your circadian rhythm is built on contrast (via the suprachiasmatic nucleus):
> ☀️ High-lux days (10,000+ lux)
> 🌑 Low-lux nights (<10 lux)
And if you stay indoors all day?
You’re getting 100–250 lux.
= loss of contrast = disrupted sleep
Your circadian rhythm is built on contrast (via the suprachiasmatic nucleus):
> ☀️ High-lux days (10,000+ lux)
> 🌑 Low-lux nights (<10 lux)
And if you stay indoors all day?
You’re getting 100–250 lux.
= loss of contrast = disrupted sleep
You need to be surrounding yourself with soft lights, you need to be barely able to see after the sun goes down, you need to feel like you are walking through a maze of soft yellow and black, you need to be living your late nights in a dream before you even sleep.
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The gold-standard trio for circadian health:
• Bright light by day
• Darkness at night
• Regular sleep + meal times
Paper: nature.com/articles/d4158…
• Bright light by day
• Darkness at night
• Regular sleep + meal times
Paper: nature.com/articles/d4158…
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After seeing thousands of patients in both internal medicine and psychiatry, I’ve come to believe this:
The biggest thing holding most people back isn’t external.
It’s themself... or more precisely, the version of themself that was "shaped" to survive.
Let me explain.
Self-sabotage is a coping mechanism serving an unconscious need. That need usually arises from real pain = abandonment, rejection, trauma, shame.
And because the pain is overwhelming, the brain finds a workaround: avoidance, perfectionism, people-pleasing, numbing, overthinking.
At first, these strategies work.
But over time, they become armor.
And that armor starts to define the yourself = your "self-concept" is born.
Your self-concept can raise you or deflate you.
You can begin to believe things like:
“I’m not ready”
“I don’t deserve good things”
“I’ll never be X enough and people will know it”
And every opportunity (good or bad) that challenges these beliefs feels threatening. So you self-sabatoge.
You pull back. justify. victimize. procrastinate. quit. relapse.
All in the name of staying safe -> inside the version of yourself that once kept you alive.
In medicine we see a similar process: an abscess can trigger long-term damage because the immune system which at first serves a protective mechanism later over-reacts to cause even more damage downstream.
With your mind: to heal, examine what is causing damage, learn why it's there (what is it coping for), and cut out the self-sabotage by fulfilling that need in a new, healthy way.
The biggest thing holding most people back isn’t external.
It’s themself... or more precisely, the version of themself that was "shaped" to survive.
Let me explain.
Self-sabotage is a coping mechanism serving an unconscious need. That need usually arises from real pain = abandonment, rejection, trauma, shame.
And because the pain is overwhelming, the brain finds a workaround: avoidance, perfectionism, people-pleasing, numbing, overthinking.
At first, these strategies work.
But over time, they become armor.
And that armor starts to define the yourself = your "self-concept" is born.
Your self-concept can raise you or deflate you.
You can begin to believe things like:
“I’m not ready”
“I don’t deserve good things”
“I’ll never be X enough and people will know it”
And every opportunity (good or bad) that challenges these beliefs feels threatening. So you self-sabatoge.
You pull back. justify. victimize. procrastinate. quit. relapse.
All in the name of staying safe -> inside the version of yourself that once kept you alive.
In medicine we see a similar process: an abscess can trigger long-term damage because the immune system which at first serves a protective mechanism later over-reacts to cause even more damage downstream.
With your mind: to heal, examine what is causing damage, learn why it's there (what is it coping for), and cut out the self-sabotage by fulfilling that need in a new, healthy way.
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