How does the retina distinguish an object moving through the world from the world moving around us? In work led by Pratyush Ramakrishna (w. Josh Morgan), we discover motion-coherence selectivity—and show how single-cell and population geometry create it. science.org/doi/10.1126/sc…

To bridge the gap to translation, we developed an RP model in adult human retinal explants and show that both gene therapies protect photoreceptors, highlighting their therapeutic promise as mutation-agnostic strategies against proteotoxicity. authors.elsevier.com/a/1mvXe3BtfHGo…

New study led by @NingShenStella w/ @phruzycki: a genome-wide in vivo CRISPR screen in a retinitis pigmentosa mouse model identifies genes whose loss accelerates photoreceptor death. Overexpressing two, UFD1 and UXT, preserves photoreceptors, retinal function, and vision. 🧵

The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa

In a new study led by @jmkrizan, we explore the origins of direction selectivity in superior colliculus and its contributions to predation, identifying behavioral multiplexing of complex feature preferences. bit.ly/49YwYZl

In a new study led by Emily Hsiang and @NingShenStella , we uncover parallel pathways for spatial and temporal information of naturalistic stimuli, respectively, in the early visual system. rdcu.be/dz5g7

@Marlafeller@mstdn.science and I wrote a review on the organization of retinal projections to the brain and their development. Hopefully, it is useful to some. bit.ly/3GxadP2

A review of neurodegeneration in the eye, its convergent pathogenesis, and innovative approaches to preserving and restoring vision. Hopefully, it is useful to some. bit.ly/3ZOHNZH

Preprint from a collaboration with the x-less Morgan lab (connectomics experts) combining two-photon calcium imaging and 3D electron microscopy in the same tissue to map the varied subcellular information paths through a retinal interneuron. bit.ly/43YF4xr

In collaboration with the twitterless Morgan lab (lead), we developed an approach to combine functional two-photon imaging with electron microscopy reconstructions to study dendritic processing in genetically identified neuron populations. bit.ly/3TwrrB7

Mike Fitzpatrick (@mike_fitz23) and I wrote a review on homeostatic plasticity in the retina. We think homeostatic plasticity is critical for retinal development and function and could be an important tool for preserving and restoring vision. bit.ly/3TfbWO0

@mike_fitz23 and I wrote a review on homeostatic plasticity in the retina. We think homeostatic plasticity is critical for retinal development and function and can be an important tool for preserving and restoring vision. bit.ly/3TfbWO0

This paper is now out in JNeurosci (bit.ly/3UvrgGZ). Thanks to Nai-Wen Tien, @cvitale91, and @tudorcb.

A review on retinal feature representations and their uses in the brain. Hopefully, it is useful to some. bit.ly/3MVEvMJ

New preprint that identifies a genetic intersection labeling an evolutionarily conserved and functionally mysterious retinal ganglion cell, maps its projections to the brain and reveals developmentally precise axon targeting. Nai-Wen Tien /w @tudorcb bit.ly/3o4CvIr

Learn more about our Neuroscience Program at the SFN Graduate School Fair #WashUNeuroPhD @WUSTLdbbs @WashUONR @WUSTL_ENDURE

Interested in a PhD in Neuroscience?
Join us for a virtual open house to learn about the Neuroscience PhD program at Washington University in St. Louis. Register at: bit.ly/3nkqsFi

A while ago, I learned that I would receive the 2022 Cogan Award from @ARVO. I am very grateful for this honor and proud of the lab members whose work it recognizes. Shortly after I was notified, I came across this headline. I just thought I’d mention it.