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bit.ly/4kkWMEu

📢 New in @eBioMedicine: scientists identify spatially organized disruption of autophagy–lysosome coordination as a key #epithelial mechanism linking alcohol exposure to #intestinal barrier dysfunction and gut–liver disease progression.

#OpenAccess🔗 bit.ly/4z1kN9N

Using single cell multiomics, researchers demonstrate that #inflammatory exposure and cellular plasticity imprint a lasting transcriptional and #epigenetic memory on #IntestinalStemCells and their progeny, priming them for enhanced repair after subsequent injuries!

#OpenAccess🔗 go.nature.com/4ivKqcD

🚨Become an expert on using #organoids in drug discovery with @STEMCELLTech!

Stay up-to-date with current applications, new products, insights from key opinion leaders, and more!

New research found that ubiquitin-specific peptidase 18 (USP18) stabilizes keratin 16 (KRT16) protein through deubiquitination and thereby promotes #ColorectalCancer (CRC) cell proliferation and migration across multiple cellular backgrounds.

🧪These findings support the andidate molecular axis warranting further preclinical evaluation in #CRC!

Find out more: bit.ly/4A5XBYZ

🧪 Researchers demonstrated that withaferin A is a potent and promising natural compound that induces apoptosis and ferroptosis in #GastricCancer cells through reactive oxygen species-mediated #mitochondrial damage and the Keap1/Nrf2/HO-1/GPX4 signaling pathway, respectively!
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📢 This review in Pharmacological Research comprehensively summarizes the current molecular mechanisms by which #EndoplasmicReticulum stress and #Mitochondrial dysfunction aid #IBD pathogenesis.

Review 🔗 | bit.ly/3Ugq7YP

📢 New research supports CLDN1 as a candidate colorectal cancer-associated marker linked to malignant epithelial-cell states, tumor-associated spatial heterogeneity, invasive phenotype, and Nutlin-3a (−) response.

#OpenAccess👉 : bit.ly/3WpqmkO

#ColorectalCancer #IntestinalResearch

Metabolic plasticity enables #ColorectalCancer (CRC) cells to adapt to energy stress, contributing to #tumor progression and therapeutic resistance.

💡Results from a study in Biochemical Pharmacology provide mechanistic insight into the #anticancer activity of aripiprazole and olic plasticity as a therapeutic strategy for #CRC!

Find out more: bit.ly/486Wr3v

Findings in this study (@cellhostmicrobe) identify Gemella morbillorum as a candidate onco-pathogen in #ColorectalCancer that uses multiple mechanisms to disarm the #intestinal barrier and trigger genotoxicity.

#OpenAccess🔗: bit.ly/4icn1gh

Findings from this study in @NatureMicrobiol reveal #bacterial interactions regulating #intestinal function and a potential clinical therapeutic approach to preventing outcomes of #enterotoxigenic Bacteroides fragilis colonization.

Find out more: go.nature.com/4jieIBO

Data from this study in @sigtrans_sttt reveal a Paneth cell-intrinsic endoplasmic reticulum stress mechanism linking ATZ accumulation to gut epithelial dysfunction, highlighting a previously underexplored role of the gut–liver axis in AAT deficiency.

Read the #OpenAccess paper: go.nature.com/4ihLu4W

#PanethCell #EndoplasmicReticulum #IntestinalResearch

Findings from a new study in @cgtnature suggest that targeting the m6A modification pathway holds promise for gastric cancer therapy, as the newly identified METTL3-E2F2-MCU axis plays a key role in regulating mitochondrial calcium homeostasis!

🔗 go.nature.com/47EWDqu
inalResearch #Mitochondria

Researchers from @UChicago built a comprehensive atlas of cell-type-resolved #chromatin accessibility which provides a comprehensive resource to study gene-regulatory effects in #CrohnsDisease and health.

This atlas in @NatureGenet highlights the cellular complexity underlying 🔗 go.nature.com/4dhy8mu

Findings from a study in @jlipidres suggest that loss of ceramide synthases 5/6 exacerbate myristate-induced intestinal endoplasmic reticulum stress in colon epithelial cells.

Find out how accumulation of dhsphingosine may provide protection in the #OpenAccess paper here: bit.ly/4hEXa0a

#Colon #EpithelialCells #EndoplasmicReticulum

Study findings reveal an intestinal effector-triggered immunity guard system that couples pore-forming toxin-damage sensing to comprehensive epithelial recovery, with physiological relevance for mucosal homeostasis across metazoans!

Read the #OpenAccess paper here: bit.ly/4xWHuM7

#IntestinalResearch #Immunity

Scientists summarized the key intercellular dialogs that regulate fibroblast-to-myofibroblast transition during the onset and progression of intestinal disorders, further analyzing their regulatory mechanisms.

🔍Read the review: bit.ly/47jaouN

#IntestinalResearch #FMT

Scientists from @PennMedicine present a retrospective review 📝 of #intestinal tract biopsies from patients treated with various cellular #immunotherapies (BCMA and CD19-directed CAR T, teclistamab and rituximab therapies).

🔗 bit.ly/4xJmoAI

#OpenAccess

Researchers synthesized recent evidence to propose an updated framework for early gastric carcinogenesis based on field evolution, lineage instability, ecosystem support, and pathway divergence.

Check out this review 👀: bit.ly/3TKyOdy

Findings point to the potential of dietary compounds 🥗 to modulate #IntestinalStemCells as a strategy to alleviate colorectal lesions.

Learn more: bit.ly/4Ap91rT

🔬 Scientists identified functional zebrafish intestinal #StemCells in the proliferative zone of intestinal furrows that can differentiate into nearly all characterized epithelial cell lineages.

Read the #OpenAccess article in @CellReports here: bit.ly/4haXxQ2.