🚀 Boosting bacterial immunopeptide discovery! Our bioinformatics workflow integrates 4 search engines with follow-up rescoring to enhance ID by 27%, maximizing the discovery of vaccine candidates. Applied to timsTOF/Thermo data🦠💉 @ImpensLab

🔗Read: pubs.acs.org/doi/full/10.10…

Happy to share our immunopeptidomics pipeline using four search engine with follow-up rescoring to boost confident IDs. Also applied to timsTOF SCP data!

@ImpensLab @compomics

Preprint: biorxiv.org/content/10.110…

Excited to share our latest MCP article uncovering > 6,000 MHC class I immunopeptides in Listeria-infected mice, including 12 Listeria peptides and a potent CD8+ T cell epitope. Many thanks to all co-authors for the excellent work! Read more at doi.org/10.1016/j.mcpr…

Here it is: our paper on the benefit of using in silico predicted libraries in DIA 🎉🎉🎉😎🙏
pubs.acs.org/doi/10.1021/ac…

@KrisGevaert_VIB @RalfGabriels @RobbinBouwmees @SaraDuf79861163 @mtpmmaia @VIBProteomxCore @ImpensLab

Proud to have it out there! The setup that boosts our throughput!💪😎 pubs.acs.org/doi/10.1021/ac…

Meet SlyB, a lipoprotein that forms stress-induced #lipidraft in the bacterial outer membrane.

Off the hands of the great @ArneJanssens95 and @nguyenson85, in collaboration with @JFClab @ImpensLab and Alex Pak lab.
@structbiolbxl @BECM_VIB

nature.com/articles/s4158…

👏Congratulations to @kkariko & @weissmanlab on becoming #NobelPrize laureates. A lifetime achievement celebrating their important research on #mRNA technology in vaccines.
🤔Did you know VIB, together with @VUBrussel, @ugent and participation of several international instthe #BAXERNA consortium to further explore the potential of mRNA vaccines?

We are looking for a #postdoc position in #immunopeptidomics @ VIB & UGent with proteomics/peptidomics expertise to develop novel antibacterial #vaccines, see jobso.id/g492. A warm call to proteomics postdocs to apply!

Research on #Moyamoya disease @ImpensLab: "Rare diseases result from dysregulated, often yet unknown molecular pathways. Investigating these conditions can lead to groundbreaking fundamental discoveries while opening treatment options for the patients."

We are very excited and extremely grateful to receive this #ERCCoG grant from @ERC_Research. It is a recognition for the whole team and we thank @VIB_CMB @ugent @ugent_fge @VIBLifeSciences @FWOVlaanderen and many others for their continuous support!

Another wonderful story from the Radoshevich lab. A must-read (and watch!) for all Listeria and comet tail aficionados.

💉 Francis Impens and team (@ImpensLab @VIB_PRC @VIB_CMB) design an mRNA vaccine against Listeria and open the door for other antibacterial vaccines.
bit.ly/3g89LwR

Finally published!
Thank you all co-authors for their priceless contribution!

Here we designed mRNA vaccine formulations against Listeria using immunopeptidomics

Looking forward to continue our efforts to tackle other intracellular bacterial pathogens
tinyurl.com/vaccineListeria

@ImpensLab
@rup_mayer
@NatureComms
@ugent
@VIBLifeSciences
@VIB_CMB
@FWOVlaanderen
#vaccines

Happy to share our new review on Moyamoya disease and RNF213, a disorder for which the etiology is still unknown.

Here, we examined the recent body of literature suggesting immune-related insults as a trigger for Moyamoya disease onset.

cell.com/trends/molecul…

@ugent

@VIBLifeSciences

@VIB_CMB

@FWOVlaanderen

First day of the 4-day BePA Proteomics Summer School @ VIB starting with interesting talks on Proteomics applications and the DOs and DONTs of sample preparation
👉👉 bit.ly/3CELRCf
#proteomics #tech #training #summerschool

Very happy to share our work on mRNA vaccine formulations against Listeria

MS and immunopeptidomics hold great promise to uncover antigens for next-generation vaccines, especially for intracellular bacteria. Incredibly grateful to all co-authors for their dedication and efforts!

@ugent @VIBLifeSciences @VIB_CMB @FWOVlaanderen

biorxiv.org/content/10.110…

#Immunopeptidomics #AntigenDiscovery #Listeria #BacterialPathogens #MassSpec #VIB #UGent