Realized that the SPM Anatomy toolbox was published 15 years ago (May 2005: pubmed.ncbi.nlm.nih.gov/15850749)

➡️ That software aged better than me

⬇️ Time for a massive update: The beta-version of v3.0 can be found on our website (fzj.de/inm/inm-7/EN/R…), paper to come hopefully soon

Autistic adults communicate just as much—but differently.
Across 4 months, adults with ASD used less verbal and more written communication, with similar total communication time.
Take-home: communication preferences matter.
doi.org/10.1038/s41746…
#Autism #DigitalHealth

Warum ist es so schwer, KI fair zu gestalten? Mein Vortrag (morgen 7.10. um 14 Uhr) in Essen oder online per live-stream:

uni-due.zoom-x.de/j/67478168941?…

What ages the brain? Not one risk factor—but a lifetime of exposures.

Across 261 variables, cardiovascular/metabolic health, smoking, alcohol, diet & bone health stood out. Timing and duration mattered.

-> Brain-health prevention should start early.

doi.org/10.1038/s41467…

What ages the brain? Not one risk factor—but a lifetime of exposures.

Across 261 variables, cardiovascular/metabolic health, smoking, alcohol, diet & bone health stood out. Timing and duration mattered.

-> Brain-health prevention should start early.

doi.org/10.1038/s41467…

This image appears in the article “Comparative insights into insula structure and function,” published in Nature Neuroscience (2026), but it is based on the meta-analysis by Eickhoff and colleagues, “A link between the systems: functional differentiation and integration (1/6)

What drives the sleep-related depression(SRD)?
Using >100,000 UK Biobank participants, @lwcvs1029 found the top modifiable predictors of SRD:
🗣️ less confiding in others
📺 more sedentary TV time
🏃 less exercise
🚬 passive smoking
medrxiv.org/content/10.648…

🧠😴📝 New preprint from the #ENIGMASleep WG!
Led by @Harvey_Bi2333.
We pooled data from 7 international sites (n=2,372) to predict cognitive performance from demographics, sleep, and brain morphometry using #MachineLearning
📄 Preprint: lnkd.in/eAZRrvzf

🚨 New paper in Molecular Psychiatry
Panic disorder is not just a “fear circuit” problem
We take a multiscale perspective, linking
🧠 brain activity
🧬 gene expression
💊 neurotransmitter systems
rdcu.be/fk06Q
@molpsychiatry

Sleep is a non-negotiable necessity and a cornerstone of whole-body health. The physical, social, and lifestyle exposome disrupts human sleep and ecosystems. We propose an #OneSleep framework that demonstrates how environmental factors influence sleep today, incorporates the and adopts a transdisciplinary lens of neuroscience, medicine, environmental sciences, and public health. Delighted to publish this @CellRepMed work with @MasoudTahmasian , Vincent Kuppers, Sarah Genon,  @INM7_ISN , &  @DiegoGolombek : doi.org/10.1016/j.xcrm…

Your brain is not shaped by a single decision. It is shaped by thousands of exposures accumulating across decades.

Every night of poor sleep.
Every chronic stress cycle.
Every city you lived in.
Every relationship.
Every hormone fluctuation.
Every period of cognitive overload.
s to this as the exposome.

The total environmental and biological load acting on your brain across your lifespan.

What most people experience as “intuition” or “mental sharpness” is often the visible output of invisible exposures interacting with neural architecture for decades before the moment arrives.

Your cognitive performance did not emerge in isolation.
It was built.

The world must urgently address the silent epidemic of poor #sleephealth.
Our new "One Sleep Health" framework calls for systemic action.
#OneSleepHealth #Onehealth #Exposome
📖 cell.com/cell-reports-m…

Here's bonus slides on cross-validation tests, separate from our preprint. Covering:

1. paired (sign-flip) permutation test
2. label-swap permutation test
3. sample-level vs fold-averaged stats
4. a common misapplication of the corrected t-test
5. three bootstrap variants 1/N

A range of exposures across the #Lifespan interact w/ genetic factors to shape one's neurocognitive phenotype. Deciphering how this complex web of influences shapes individual brain–behaviour phenotypes comes w/ substantial challenges. @NatRevNeurosci 👉 nature.com/articles/s4158…

Brain–body-environment interactions must move beyond isolated exposures toward the expotype: the dynamic configuration of physical, social, lifestyle, and internal factors that jointly shape brain–behaviour phenotypes. At @NatRevNeurosci (nature.com/articles/s4158…), we propose a the exposome as a complex, time-varying system that requires nonlinear models to capture interactions, thresholds, synergistic effects, and cross-domain buffering mechanisms. Although predictive machine learning can support individual risk estimation, the next frontier is to move from prediction to mechanism, from association to dynamic synergetic inference. Multivariate learning, causal machine learning, aging clocks, longitudinal designs, and generative biophysical digital twins are beginning to provide this bridge. Brain–body–environment diversity can reveal how ecology becomes biologically embedded. We call for a future exposomic neuroscience that integrates nonlinear temporal modeling, generative mechanisms, and population diversity to understand, simulate, and modify trajectories of brain aging and disease. Congrats Sarah Genon, @MasoudTahmasian & @INM7_ISN

🔬 New preprint: We introduce NEOFC—a framework linking brain connectivity to neurotransmitter systems. Reveals robust neurochemical signatures, strong noradrenergic effects, and sensitivity to drugs & psychosis.

📄 biorxiv.org/content/10.648…

#Neuroscience #Neuroimaging

When discussing structure-function relationships across brain scales, note that the definition of function often changes - keep it straight! With @INM7_ISN
link.springer.com/article/10.100…

Our comprehensive review highlights the complex, bidirectional relationship between #sleepdisturbances 🛌 and #Alzheimer’s disease 🧠

We further present a framework integrating the different evidence and propose a path forward for future biomarker research:
nature.com/articles/s4138…

@INM7_ISN @fzj_inm7 @leoschilbach Leon Lotter Casey Paquola

Our new publication, led by Vincent Küppers, on the multivariate association between #Sleep, #Mood, #BrainHealth & #Motor performance across different adult age groups.
doi.org/10.1038/s41598…

👉Up next, we are excited to welcome @INM7_ISN for our next CCP Speaker Series talk! Join us THIS FRIDAY, December 5th, at 1pm EST

RSVP HERE for more details: docs.google.com/forms/d/e/1FAI…