Great to see the fine piece of work in the public domain - a single amino acid in the Tie1 ectodomain (allowing cleavage vs. no cleavage) making the difference between angiogenesis and inflammation - nothing compares to the power of discoveries in definite genetic in vivo models!
This Research Letter identifies a long sought molecular switch in a pathway that regulates both blood vessel growth and inflammation: doi.org/10.1172/JCI204…
Mahak Singhal @mahak906, Hellmut G. Augustin @HellmutAugustin & team @uniklinik_hd find that ectodomain cleavage of the vascinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental #vascular programs.
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Congratulations to Ki Hong Lee & Moritz Jakab for their landmark paper in @NatureComms showing that endothelial cell Wnt-mediated angiocrine signaling in the liver is controlled by hemodynamic forces and not by oxygen gradients. Stunningly beautiful work! nature.com/articles/s4146…
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Congratulations to Xiaowen Zhang for her spectacular publication in @CD_AACR identifying a subpopulation of LPL-expressing intratumoral endothelial cells that decisively controls the anti-tumor immune response in liver metastases. See: aacrjournals.org/cancerdiscover…
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Hellmut Augustin retweeted
Double ERC success for DKFZ researchers: @HellmutAugustin and Michael Platten @Platten_lab have been selected by the European Research Council @ERC_Research for the prestigious Proof of Concept (PoC) grants. #ERCPoC 👏
t1p.de/zau31
t1p.de/zau31
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Exciting new work for the Angiopoietin aficionado: Angiopoietin dysregulation as early hallmark of amyloid- driven vascular dysfunction in Alzheimer's disease. Must read work from the @wysscoray and @CCB_CBI lab published on @biorxivpreprint.
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Three new @ERC_Research Starting Grants for vascular researchers: Congratulations to Vanessa Coelho-Santos (@vcoelhosantos) for "AngioArchitects“ (LS5], Leire Bejarano (@BejaranoLeire) for "MetaVasc" (LS4], and Mahak Singhal (@mahak906) for "Vascular Rhythm" (LS4). Great success!
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Congratulations to Mahak Singhal (@mahak906) @UniHeidelberg on being awarded an @ERC_Research Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". A new branch of vascular research!
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2025 has been an intense and in part rough year. Time to let body and soul heal and recover. Found a wonderful place overlooking Costa Adeje on the lovely island Tenerife (oceanviewmontesol.com). Spectacular view – plenty activities – great new ideas - feels like rejuvenation!
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Still time to apply to the 2 open 6-year Junior Group Leader positions at the European Center for Angioscience (ECAS) @UniHeidelberg. Application deadline is September 10, 2025.
Spread the word: The European Center for Angioscience @UniHeidelberg continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @Nature: nature.com/naturecareers/…
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Interested in pursuing a postdoc in the Augustin lab at the German Cancer Research Center in Heidelberg (augustinlab.de)? Working at the interface of angioscience and metastasis. Apply to the DKFZ postdoc fellowship program (dkfz.de/en/karriere/in…). Deadline: Sept. 15.
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Spread the word: The European Center for Angioscience @UniHeidelberg continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @Nature: nature.com/naturecareers/…
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Following our epigenetic placental vasculature paper @Dev_Cell (sciencedirect.com/science/articl…), the second chapter of our forthcoming vascular epigenetic trilogy was now published in @NAR_Open (academic.oup.com/nar/article/53…): DNMT3A regulation of endothelial enhancer landscape. More to come!
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Hellmut Augustin retweeted
Don Nguyen, PhD (center) chaired an Education Session #AACR25 on Non-Genetic Drivers of Cancer Metastasis featuring @HellmutAugustin and @LaughneyLab. @AACR @yalepathology @SmilowCancer
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Another hyped study in @NatureMedicine claiming to have developed a predictive test for the identification of women at risk of developing preeclampsia. Sobering: The predictive value is no better than the cheap routine measurement of sICAM & sVCAM reported more than 20 years ago.
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Gratifying to now see our pericrine liver work in the print version of @Nature (nature.com/articles/s4158…). Massive piece of work with 651 display items (174 main, 477 supplement). Feels like we are publishing books and not papers. Thanks to @RobSchwabe for great collaboration!
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Angiocrine signaling is rocking - pericrine signaling is the new kid on the block: Hepatic stellate cells control liver function (‘HSCs make the liver great again’) – now published @Nature (nature.com/articles/s4158…). Fantastic collaboration with the @RobSchwabe lab @ColumbiaUniv.
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Spectacular hemangioma work from @BischoffJoyce lab in @jclinicalinvest. Fantastic basic science (discovery of SOX18-mevalonate pathway in hemangioma) combined with great translational perspective (drug repurposing). Congrats to Anne Holm! Check it out: dm5migu4zj3pb.cloudfront.net/manuscripts/17….
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Hellmut Augustin retweeted
Online now: The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms dlvr.it/THMCSS
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Dear Community: I really liked X as a science communication platform. But, sadly, it has deteriorated to a science-ignoring, fake (alternative) news-spreading, conspiracy-promoting, and far right wing advocacy social media platform. Time to move on. See you on Bluesky. Hellmut
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