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Excited to share our work on mitochondrial metabolism and gene expression. Thanks to all the authors, Stirling, and collaborators!!!
Summary and shareable link ⬇️
Summary and shareable link ⬇️
🎉Our paper "Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression" is now online! 🎉
nature.com/articles/s4155…
Summary ⬇️but the published manuscript is greatly expanded! Congratulations to Nick Kramer, @GyPrak thanks to @KanarekNaama for collab.
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Gyan Prakash retweeted
Can’t really find the words to describe how proud and enthusiastic I am to share the results of my postdoc work, just published in @Nature. 6+ years of countless microscopy hours, innumerable surgeries, weeks-long experiments and sleepless nights 1/6 nature.com/articles/s4158…
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Gyan Prakash retweeted
New preprint from the lab!
𝗖𝘆𝘁𝗼𝘀𝗼𝗹𝗶𝗰 𝗡𝟲𝗔𝗠𝗧𝟭-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘁𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝘀 #𝗺𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮𝗹 𝗥𝗡𝗔 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴
biorxiv.org/cgi/content/sh…
By Mads Foged et al.
A 🎬 and a 🧵
𝗖𝘆𝘁𝗼𝘀𝗼𝗹𝗶𝗰 𝗡𝟲𝗔𝗠𝗧𝟭-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘁𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝘀 #𝗺𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮𝗹 𝗥𝗡𝗔 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴
biorxiv.org/cgi/content/sh…
By Mads Foged et al.
A 🎬 and a 🧵
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Awesome work @AriSarfatis, super cool biology.
So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12
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Gyan Prakash retweeted
Job Alert!
Our lab is recruiting a Postdoctoral fellow to work on the interplay between mitochondrial morphology, mb contact sites, mtDNA dynamics and quality control.
Have a look if interested! @MRC_MBU @Cambridge_Uni
jobs.cam.ac.uk/job/46901/
Our lab is recruiting a Postdoctoral fellow to work on the interplay between mitochondrial morphology, mb contact sites, mtDNA dynamics and quality control.
Have a look if interested! @MRC_MBU @Cambridge_Uni
jobs.cam.ac.uk/job/46901/
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Happy to be a part of this beautiful story!! Congrats @ErikMcshane and everyone involved
Very excited to see our work featured on the cover of the latest edition of Molecular Cell. Check out our manuscript to learn more about how the nuclear genome works together with the highly polyploid mitochondrial genome across the cell.
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Gyan Prakash retweeted
Very excited to see our work featured on the cover of the latest edition of Molecular Cell. Check out our manuscript to learn more about how the nuclear genome works together with the highly polyploid mitochondrial genome across the cell.
Our latest issue is now out: cell.com/molecular-cell…
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Gyan Prakash retweeted
Move over mitochondria, a new organelle called the nitroplast is here.
In a new Science study, researchers report that a nitrogen-fixing organelle has been identified in a marine alga.
Learn more ⬇️
📄: scim.ag/6BE
#SciencePerspective: scim.ag/6BF
In a new Science study, researchers report that a nitrogen-fixing organelle has been identified in a marine alga.
Learn more ⬇️
📄: scim.ag/6BE
#SciencePerspective: scim.ag/6BF
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Great work @ErikMcshane and team!!! Happy to see it out
Online Now: A kinetic dichotomy between mitochondrial and nuclear gene expression processes dlvr.it/T4FSGx
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Gyan Prakash retweeted
Online Now: A kinetic dichotomy between mitochondrial and nuclear gene expression processes dlvr.it/T4FSGx
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Gyan Prakash retweeted
🎉 🎉Our paper, "Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA," is now published! rdcu.be/dyqzP @NatureSMB
See the tweets below ⬇️ for a summary. Congratulations to the whole team! @RsIsaac @mtcicero26 @stergachislab 🎉🎉
See the tweets below ⬇️ for a summary. Congratulations to the whole team! @RsIsaac @mtcicero26 @stergachislab 🎉🎉
How are the hundreds of copies of mitochondrial DNA packaged in our cells? It’s a mystery because histones and chromatin factors are not in mitochondria and the high copy number presents challenges! Read what Stefan @RsIsaac found in our preprint. (1/7)
biorxiv.org/content/10.110…
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Gyan Prakash retweeted
☕️NEW: Churchman & co share #CRISPRscreen for factors altering the levels of 2 dual-genome-encoded #ComplexIV subunits and identify PREPL and NME6 as genes that connect #MitochondrialMetabolism to #mtDNA expression.
@fiddle @GyPrak
rdcu.be/dnIpr
nature.com/articles/s4155…
@fiddle @GyPrak
rdcu.be/dnIpr
nature.com/articles/s4155…
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Gyan Prakash retweeted
How do cells get their lipid headgroups? @HiteLabMSKCC + @KivancBirsoy show that FLVCR1 is the major transporter for *both* choline and ethanolamine in mammalian cells. Big new addition to the Kennedy pathway + structures to boot! biorxiv.org/content/10.110…
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Gyan Prakash retweeted
🎉Our paper "Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression" is now online! 🎉
nature.com/articles/s4155…
Summary ⬇️but the published manuscript is greatly expanded! Congratulations to Nick Kramer, @GyPrak thanks to @KanarekNaama for collab.
nature.com/articles/s4155…
Summary ⬇️but the published manuscript is greatly expanded! Congratulations to Nick Kramer, @GyPrak thanks to @KanarekNaama for collab.
How are nuclear and mitochondrial DNA co-regulated to achieve balanced oxidative phosphorylation (OXPHOS) subunits? We performed a CRISPR screen to identify human genes that maintain mitonuclear balance. See our preprint by Nick Kramer and @GyPrak (1/4) biorxiv.org/content/10.110…
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Gyan Prakash retweeted
Excited to announce the pre-print (biorxiv.org/content/10.110…) for our work studying the biogenesis pathways of mitochondrial outer membrane alpha-helical proteins! A really fun collaboration with the (@voorheeslab). Follow this 🧵 for a sneak peak (1/12)
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Check out the cool work by @ErikMcshane to know more about mitochondrial gene expression. Always great to see a part of the rotation project to a culmination. Thanks, @fiddle for the opportunity, and to @robertietswaart for the mentorship.
Another new preprint! “Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the RNA life cycle.” Let us walk through a day in the life of a mitochondrial RNA. @ErikMcshane led this beautiful study. (1/n)biorxiv.org/content/10.110…
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Gyan Prakash retweeted
Today, we and @ganetzky1 report @NEJM a remarkable case of twin boys with euthyroid hyper-metabolism (low body weight despite high caloric intake), due to a de novo mutation in mito CV that uncouples respiration from ATP synthesis. nejm.org/doi/full/10.10…
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Gyan Prakash retweeted
We are looking for a new research assistant! Join us in @lab_manning to help unravel the regulation and function of mTOR signaling in health and disease, with studies focused on insulin and nutrient signaling, cancer, neuroscience, and aging. hsph.harvard.edu/manning-lab/
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Gyan Prakash retweeted
We're looking for a postdoc to study cancer cachexia. Please RT! jobrxiv.org/job/harvard-t-…
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Gyan Prakash retweeted
Join me at hybrid @KeystoneSymp #GeneRegulation: Emerging Technologies to New Models now in June! Collaborate in Santa Fe with experts on #GeneExpression #Chromatin and more or connect via virtual access. keysym.us/KSGeneRegulati… #KSGeneRegulation22
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