Puri Fortes retweeted
Excited to share our latest work in @CancerDiscovery!
We show that blood can reveal both cancer neoantigens and the rare T cells that recognize them, without relying on tumor biopsies.
A step toward less invasive, more accessible personalized cancer immunotherapies!
We show that blood can reveal both cancer neoantigens and the rare T cells that recognize them, without relying on tumor biopsies.
A step toward less invasive, more accessible personalized cancer immunotherapies!
Now online: Peripheral Blood as the Sole Source of Cancer Neoantigen and Reactive T-cell Discovery doi.org/10.1158/2159-8…
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Congrats Maite, well deserved!!!
La Dra. Maite Huarte recibe el XXXI Premio Carmen y Severo Ochoa de Investigación en Biología Molecular ➡️ La investigadora del Cima Universidad de Navarra ha sido galardonada por desvelar nuevas claves sobre el funcionamiento de nuestros genes. bit.ly/4BXInaq
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Puri Fortes retweeted
The deaths of two children in separate gene-editing trials in China raise serious questions about oversight and could have a profound effect on the country’s biomedical industry
go.nature.com/4xbyXUU
go.nature.com/4xbyXUU
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Puri Fortes retweeted
A few months ago I was browsing google images looking at p53 western blots in the SK-OV-3 cell line for an unrelated project. I noticed an unusual western blot hosted on Thermo Fisher's website which I posted on social media. Usually I just post weird blots to PubPeer. 👇
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Un equipazo!
#ALBA | Identificación de microproteínas (MPs) para generar vacunas contra el cáncer.
👉Proyecto estratégico financiado por @gob_na
👨💻 Coordinador: @CIMA_unav
🤝Socios: @navarrabiomed, #HUN, @ClinicaNavarra, #NNBi, @nucaps_nano, @NASERTIC y #ADItech
aditech.com/es/proyectos-i…
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Puri Fortes retweeted
China approves the world’s first CAR-T therapy for a solid tumor.
Hours later, the FDA responds with full approval of afami-cel and expansion into pediatric synovial sarcoma.
A remarkable day for cellular therapy.
🇨🇳 Satri-cel (CLDN18.2 CAR-T)
CT041-ST-01, refractory gastric/GEJ cancer
• PFS: 3.25 vs 1.77 months (HR 0.37)
• OS: 7.9 vs 5.5 months (HR 0.69)
• 18-month OS: 20.1% vs 8.6%
• First CAR-T ever approved for a solid tumor
🇺🇸 Afami-cel (MAGE-A4 TCR-T)
SPEARHEAD-1, advanced synovial sarcoma
• ORR: 43%
• CR: 4.5%
• Median DoR: 6.0 months
• Median OS: 15.4 months
• First FDA-approved engineered cellular therapy for a solid tumor
For decades, solid tumors were where cellular therapies went to fail.
Now, on the same day, regulators in China and the United States have approved two different engineered T-cell platforms for two different solid tumors.
A brave new world for solid tumor oncology.
Any cancer center not providing cellular therapies is going to be left in the dust.
@OncoAlert @TheGutOncLab @Onco_Nexus
Hours later, the FDA responds with full approval of afami-cel and expansion into pediatric synovial sarcoma.
A remarkable day for cellular therapy.
🇨🇳 Satri-cel (CLDN18.2 CAR-T)
CT041-ST-01, refractory gastric/GEJ cancer
• PFS: 3.25 vs 1.77 months (HR 0.37)
• OS: 7.9 vs 5.5 months (HR 0.69)
• 18-month OS: 20.1% vs 8.6%
• First CAR-T ever approved for a solid tumor
🇺🇸 Afami-cel (MAGE-A4 TCR-T)
SPEARHEAD-1, advanced synovial sarcoma
• ORR: 43%
• CR: 4.5%
• Median DoR: 6.0 months
• Median OS: 15.4 months
• First FDA-approved engineered cellular therapy for a solid tumor
For decades, solid tumors were where cellular therapies went to fail.
Now, on the same day, regulators in China and the United States have approved two different engineered T-cell platforms for two different solid tumors.
A brave new world for solid tumor oncology.
Any cancer center not providing cellular therapies is going to be left in the dust.
@OncoAlert @TheGutOncLab @Onco_Nexus
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Puri Fortes retweeted
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
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Puri Fortes retweeted
What a nice place for the #Ribored2026!
We finished the day with a social activity: a walk around Sant Feliu de Guixols
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Super nice! Congrats!!!
Our latest work is out in Nucleic Acids Research @OxfordJournals We introduce Optical Tweezers Curtains: a method to study interactions between proteins and DNA-ends at the single-molecule level. @CNB_CSIC @SDeBraganca academic.oup.com/nar/article/54…
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Amazing talk and incredible visit today from @AgamiLab. RNA translation is full of surprises!!! Million thanks Reuven!
Today we welcome Dr. Reuven Agami (@NKI_nl), who will present: “When Mistranslation Meets Immunotherapy” organized by @FortesLab and @MaiteHuarteLab
A leading expert in #oncogenomics, his work has pioneered genetic tools to uncover how gene regulation drives #cancer.
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Puri Fortes retweeted
#AptOx26 starting tomorrow - 23rd March - at St Edmund Hall, #Oxford. Vew agenda here:
libpubmedia.co.uk/aptamers-2026/…
libpubmedia.co.uk/aptamers-2026/…
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Puri Fortes retweeted
📢 Los fondos son limitados. Ayúdanos a que #científicas en países de desarrollo tengan los recursos que merecen. ¡Cualquier aporte hasta 50€ se multiplica!!
👉¡Dona aquí!
globalgiving.org/projects/empow…
👉¡Dona aquí!
globalgiving.org/projects/empow…
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Super nice story! Do not miss this! I am still amazed about how a small protein extension can turn PTMA protein into more oncogenic! It is great to collaborate with the great Mar Alba lab! Mar… will there be a third preprint this month? 😳
Second preprint of the month!
Analysis of stop-loss mutations in > 20,000 cancer samples shows that several oncogenes and tumor suppressor genes are recurrently mutated. Another fruitful collaboration with @FortesLab @GRIB_Barcelona
biorxiv.org/content/10.648…
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Puri Fortes retweeted
New preprint from the group!
Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @the_prbb
biorxiv.org/content/10.648…
Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @the_prbb
biorxiv.org/content/10.648…
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Puri Fortes retweeted
"Zorevunersen es el primer tratamiento diseñado para actuar específicamente sobre la causa de #Dravet". Nuestro científico Rubén Hernández comenta en
@elmundosalud los resultados de un estudio internacional publicado en @NEJM
📰 Un reportaje de @cglucio
elmundo.es/ciencia-y-salu…
@elmundosalud los resultados de un estudio internacional publicado en @NEJM
📰 Un reportaje de @cglucio
elmundo.es/ciencia-y-salu…
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Puri Fortes retweeted
Nature research paper: GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling
go.nature.com/4qfSq3C
go.nature.com/4qfSq3C
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Puri Fortes retweeted
More than 2700 3′UTRs are highly conserved.
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
biorxiv.org/content/10.110…
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
biorxiv.org/content/10.110…
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