Try this. There are no “subtypes.” Each individual patient is different and can be defined at the molecular level by technology that is now routinely available in many countries.

Our latest preprint:

• Improved split-pool Perturb-seq method
• Gene programs in hiPSC-endothelial differentiation
• New role for Hippo pathway in vitro and in vivo
• Strategy for improving differentiation by faking cell density

biorxiv.org/content/10.648…

1/

Biology spans many scales and modalities.

Our new @NatureGenet paper introduces #CORAL🪸, a probabilistic deep generative model that bridges them. Applied to spatial transcriptomics + proteomics, it identified cells linked to immunotherapy resistance in liver cancer.

Excited to share that our map of the genetic interaction network of the DNA Damage Response is out in @NatureBiotech! Led by Sam Hayward, @vaitsiankova and @tlmdz_.
rdcu.be/VM8XuctGW5Ra

Snap the #QR code below to register for our next @WCMEnglanderIPM #PrecisionMedicine Research Conf., "Understanding the Impact of #Myeloid Mutations in Patients Undergoing #SolidTumor Therapy," presented by the Clinical Director of EIPM's Molecular Aging Inst. @DrPinkalDesai!

Excited to share our latest work in @CancerDiscovery!

We show that blood can reveal both cancer neoantigens and the rare T cells that recognize them, without relying on tumor biopsies.

A step toward less invasive, more accessible personalized cancer immunotherapies!

AI agents enter the wet lab.

In new @Nature N&V article, I discuss recent advances in agents running automated labs and ideas on how to make these systems more reliable. nature.com/articles/d4158…

New in @NatureMedicine , and a clever bit of engineering!

TIL therapy can work, but the IL-2 required can be tough on patients. So researchers engineered the cells to carry IL-15 on their surface, which can be controlled with an FDA-approved pill (acetazolamide). No IL-2 needed!
hat had stopped responding to immunotherapy, 10 of 15 patients responded, including 2 complete responses.

Lower-dose chemotherapy to prepare patients, and even the option of a needle biopsy instead of surgery to collect tumor tissue.

Small numbers, early days. But an encouraging step toward making cell therapy more accessible to patients!

#CancerResearch is a long-term bet the American people have chosen to make. Former @NIH and @theNCI Director Dr. Harold Varmus calls it “the high point of American civilization.” For people with cancer, that investment means better prevention, treatment, and survival. #YourNCI

🚨 We are hiring! Please help spread the word! Very excited to announce an open-rank, tenure-track faculty search in #Computational #Biology at @CMUCompBio @GriffinCMU @CarnegieMellon !

We welcome exceptional candidates from ALL areas of computational biology, including AI for biology, autonomous science, structural biology, drug discovery, synthetic biology, genomics, imaging, precision medicine, and beyond !

With the historic investment in CMU's Kenneth C. Griffin School of Computer Science @GriffinCMU, this is an especially exciting time to join us and help shape the future of scientific discovery!

📅 Deadline: Dec 16, 2026
🔗 Apply: apply.interfolio.com/189576

More details: cmu.edu/cbd/join-us/te…

Mark your calendar and plan to join us (virtually) on Nov. 18th at 2 pm for the @WCMEnglanderIPM #AI Clinic "Hardening Your Vibe Analyses with #Mycelium," led by Dr. Arjun Raj (@arjunrajlab) from @UofPenn #BioEngineering #Genetics!

Snap the QR code below to register.

Just scheduled!

Dr. J. Travis Gossey will present an @WCMEnglanderIPM #AI Clinic talk, AI Evaluation Process for Getting Solutions into #Epic," tomorrow at 2 pm!

Snap the QR code to register today!

1/12 Excited to share our new study, out today in @NatureGenet on clonal hematopoiesis (CH) & cytopenias after CAR19 therapy. Led by Mark Hamilton and team with David Miklos and @max_diehn. How do blood-cell clones evolve after CAR T vs conventional cytotoxic Rx?

We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.

We call this Weight-Space Programming: fronely read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weight-sp…

Faculty ad is out,

please help spread the word

Come #DreamBig together, without a doubt,

in the best city in the world!

jobs.sciencecareers.org/job/681004/ten…

Our three TenK10K papers are out in @Nature today!
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
nature.com/articles/s4158…

Today is #NationalMentoringDay, so we're sharing some of our favorite @WCMEnglanderIPM posts about colleagues who take the time to give back, mentor and encourage the next generation of scientists!

Please also join us on Nov. 3rd from 1-3 pm for an @WCMEnglanderIPM Special Seminar and Q & A session on #Quantitative #SpatialProteomics featuring James R. Mansfield of @Standard_BioT!

From #ESMO26 & @NEJM
Tarlatamab–Durvalumab Maintenance for Extensive-Stage Small-Cell Lung Cancer
nejm.org/doi/full/10.10…
Practice changing data for a terrible disease with hazard ratios that are unequivocal.

The NYU Department of Biology is searching for an Assistant Professor in AI-enabled biology: researchers developing or applying AI/ML to answer fundamental biological questions.

Applications due Nov 15:
apply.interfolio.com/195143

Please share!