Safety of oral naltrexone in HIV-positive men who have sex with men and transgender women with alcohol use disorder and initiating antiretroviral therapy

journals.plos.org/plosone/articl…

4) We looked at adverse events in a double-blind randomized clinical trial in Lima, Peru. Participants were recently diagnosed with HIV; they initiated ART and were randomized to receive oral naltrexone or a placebo for 24 weeks, followed by 24 weeks receiving ART alone.

5) Over 48 weeks, the frequency of clinical adverse events (1.3 per participant) and frequency of abnormal liver function tests were similar in both groups. Our study indicates that it is not only safe to prescribe ART and NTX concurrently, but to initiate them concurrently.

Sex-on-premise venues, associated risk behaviors, and attitudes toward venue-based HIV testing among men who have sex with men in Lima, Perú: rdcu.be/b3E3j

1/ Anyone want a mental break to talk about some cool #Science not related to #COVID-19? So, we all know that the @WHO guidelines state that every person living with #HIV (PLWH) should receive antiretroviral therapy (ART), right? @HIVMA @IDSAInfo @Aidsinfo @IAS-USA @iasociety

14/ So what are the conclusions? Well, we started off by stating that all PLWH should get ART right away. But now we have data to say that waiting even a short while after HIV acquisition can have negative effects on the persons symptoms, and also their immune system.

15/ Can @WHO and @aidsinfo guidelines explicitly mention starting ART during acute infection?

We think they should! And thanks to our participants @DuerrHOPEgroup @impactaperu and all our participants and amazing staff who made this work possible! @HIVMA @fredhutch @UWMedicine

Clinical and Immunologic Outcomes After Immediate or Deferred Antiretroviral Therapy Initiation During Primary Human Immunodeficiency Virus Infection: The Sabes Randomized Clinical Study academic.oup.com/cid/cid/advanc…