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Differentiation Journal@Diff_Journal
22 Apr 2024
Differentiation is the flagship journal of the International Society of Differentiation (ISD) @intlsocdiff. We are a multidisciplinary journal focusing on principal subject areas of cell and tissue differentiation, embryonic development, cellular structure and function, and 1/4
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Differentiation Journal@Diff_Journal
Nov 6
Xunwei Liu et al. established a single-cell transcriptomic atlas of zebrafish thrombocytes and integrated it with mammalian megakaryocyte datasets to enable a cross-species comparative analysis of megakaryocyte–platelet lineage development. Learn more: sciencedirect.com/science/articl…
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Differentiation Journal@Diff_Journal
Oct 30
Dianshan Ke et al. propose that targeted interventions aimed at enhancing STAT1 phosphorylation may serve as a promising therapeutic strategy for osteoclastogenic bone loss. Learn more: sciencedirect.com/science/articl…
Fig. 7. The working model regarding the relationship between STAT1 phosphorylation, regulated OCP apoptosis and osteoclastogenesis under RANKL induction. Briefly, under RANKL induction, STAT1 is phosphorylated at the Ser727 site in OCPs, which dominates the pro-apoptotic effect of STAT1 in OCPs through STAT1-p53 interaction and subsequent transcription to Bax-RNA; the above process inhibits RANKL-induced osteoclastogenesis.
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Differentiation Journal retweeted
Rosa Uribe, PhD
@uribelabrice
Oct 16
Deadline is now January 31, 2027.
Differentiation Journal@Diff_Journal
Oct 14
Deadline approaching 🚨 Submit to the "Enteric nervous system development and repair" by October 31! Learn more and submit: sciencedirect.com/special-issue/…

Keywords:
• Neural circuits
• Enteric progenitor cell
• ENS regeneration
• ENS neurons
• ENS glial cells
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Differentiation Journal@Diff_Journal
Oct 14
Deadline approaching 🚨 Submit to the "Enteric nervous system development and repair" by October 31! Learn more and submit: sciencedirect.com/special-issue/…

Keywords:
• Neural circuits
• Enteric progenitor cell
• ENS regeneration
• ENS neurons
• ENS glial cells
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Differentiation Journal@Diff_Journal
Oct 7
Findings from Raziyeh Taghizadeh Ghavamabadi et al. suggest that resveratrol may support cardiac induction while only partially attenuating the cytotoxic effects of 5-azacytidine. Learn more: sciencedirect.com/science/articl…
Fig. 2. A. MSC on day 3. Cultures were terminated on day 3 as Mesenchymal Stem Cells (MSCs) achieved confluency, a point beyond which further culture was not feasible. B. Res-only group on day 21. C. 5-aza group on day 21. D. Res 5 group on day 21. E. Res 10 group on day 21. F. Res 20 group on day 21. Perinuclear clear regions that appeared to be consistent with cytoplasmic lipid droplet accumulation are indicated by black arrows, and cell-to-cell junctions morphologically resembling intercalated disc-like structures are highlighted by a black circle. The magnification ×20.
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Differentiation Journal@Diff_Journal
Sep 30
Results from Lomeli C. Shull et al. suggest that Prdm3 and Prdm16 define cranial neural crest cell states in zebrafish development. Learn more about their research: sciencedirect.com/science/articl…
Fig. 3. Target genes from each cluster are differentially expressed in prdm3 and prdm16 mutant zebrafish.
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Differentiation Journal@Diff_Journal
Sep 23
Palak Chugh and Tathagata Biswas report on the @InSDB_79 & @intlsocdiff meeting held in Berhampur, India in December 2025. The meeting brought together scientists from across the world and showcased the latest research in development and differentiation: sciencedirect.com/science/articl…
Fig. 2. Prof. Sally Dunwoodie presented awards to the winners of the best poster presentation.
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Differentiation Journal@Diff_Journal
Sep 16
Call for papers! 🧬 "Enteric nervous system development and repair," edited by Julia Ganz and Rosa Uribe. Submit by October 31, 2026! Learn more: sciencedirect.com/special-issue/…

Keywords:
• Neural circuits
• Enteric progenitor cell
• ENS regeneration
• ENS neurons
• ENS glial cells
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Differentiation Journal@Diff_Journal
Aug 26
Findings from Justin Knapp et al. establish xZnf131 as a critical regulator required for the proper morphogenetic movements during early Xenopus development. Learn more: doi.org/10.1016/j.diff… @intlsocdiff
xZnf131-depleted embryos exhibit gastrulation defects
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Differentiation Journal@Diff_Journal
Aug 19
Jinyu Wang et al. summarized the mechanistic pathways and transcriptional regulation in atrioventricular canal endocardial cushion development and endothelial-to-mesenchymal transition, highlighting their association with congenital heart diseases: doi.org/10.1016/j.diff…
Fig. 2. Model of endocardial cushion EndMT. This figure illustrates the developmental progression of endocardial cushion EndMT. Firstly, the cardiac jelly is generated between the endocardium and myocardium. Secondly, endocardial cells (ECs) sense blood flow shear forces, lose their primary cilia, and initiate EndMT. ECs detach from the endocardium, migrate into the cardiac jelly, and transform into mesenchymal cells. During post-EndMT development, mesenchymal cells undergo proliferation, migration, and secretion of extracellular matrix, participating in the shaping of valves and the atrioventricular septum.
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Differentiation Journal@Diff_Journal
Aug 12
Nazli Busra Acikgoz et al. demonstrate that a synonymous NPR2 variant can disrupt pre-mRNA splicing, leading to loss of receptor function and impaired skeletal development. Learn more: sciencedirect.com/science/articl…
Fig. 1. Clinical and radiological features of the proband with acromesomelic dysplasia, Maroteaux type (AMDM).
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Differentiation Journal@Diff_Journal
Aug 5
“Bioluminescence temporal signatures of monocyte differentiation reveals changes in phenotype due to GM-CSF, M-CSF, and PMA induction,” by Zachary James et al. Learn more: sciencedirect.com/science/articl…
Fig. 3. Image Analysis reveals proliferation differences based on differentiation stimuli. (A) Confluency seen within each well is graphed over the measurement period. (B) Representative images comparing macrophages at day 0 and day 18, with the differentiation agent concentration increasing down the image pairs.
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Differentiation Journal@Diff_Journal
Jul 29
Sakshi Nalkande et al. present a comprehensive review of evidence from contemporary literature establishing ovarian fibrosis as a critical and increasingly unrecognized pathological manifestation of polycystic ovary syndrome: sciencedirect.com/science/articl… #PCOS
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Differentiation Journal@Diff_Journal
Jul 22
Tannaz Sakhavarz et al. provide the first comprehensive evidence that Palmatine functions as a potent, multi-level osteo-inductive molecule in human adipose-derived mesenchymal stem cells. Learn more: sciencedirect.com/science/articl…
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Differentiation Journal@Diff_Journal
Jul 15
Sydney Popsuj et al. designed and tested novel sgRNA expression plasmids targeting 8 different neurodevelopmental genes in the model tunicate Ciona robusta. Learn more: sciencedirect.com/science/articl…
Fig. 4. Table of all sgRNAs designed and tested in this study
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Differentiation Journal@Diff_Journal
Jul 8
Findings from Basant Kumar et al. identify a promoter-level reciprocal repression circuit between Goosecoid and Ventx1.1 and suggest that this circuitry contributes to the refinement of dorsoventral patterning in Xenopus gastrulae: sciencedirect.com/science/articl…
Fig. 7. Proposed model for promoter-level reciprocal repression during Xenopus gastrulation. In ventral mesodermal regions, BMP signaling activates Ventx1.1 expression through Smad1/5/8–Smad4 signaling. Ventx1.1 represses gsc transcription through VRE elements within the proximal gsc promoter. In the neuroectodermal domain, reduced BMP signaling permits Foxd4l1.1 expression, which further represses gsc transcription through BRE/FRE-containing promoter region. In dorsal organizer regions, Activin/Nodal signaling activates gsc through Smad2/3–Smad4 signaling, and Gsc represses ventx1.1 transcription through the GRE1-containing region of the ventx1.1 promoter. The FRE partially overlaps with VRE2 on the reverse strand, suggesting spatially distinct promoter occupancy by Ventx1.1 and Foxd4l1.1 during gastrulation.
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Differentiation Journal@Diff_Journal
Jul 1
Luis Herrera et al. provide the first structural framework for understanding prenatal human heel fat pad organization, extending beyond classical models of adipose tissue development. Learn more: sciencedirect.com/science/articl… #devbio #differentiation
Fig. 1. Sagittal histological section of the developing foot showing the anatomical localization of the human heel fat pad (HHFP) (CRL 177 mm; 19 GW). The calcaneus and overlying skin are identified. The inset highlights the region of interest for HHFP development. Scale bar: 100 μm.
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Differentiation Journal@Diff_Journal
Jun 24
“Bridging cells: Potential crosstalk between the peripheral and central olfactory sensory system,” by Jorge Torres-Paz, Ricardo Ceriani, and Kathleen E. Whitlock. Read the Article from the special issue "Splicing in Development and Disease": doi.org/10.1016/j.diff…
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Differentiation Journal@Diff_Journal
Jun 18
Seung Hoon Lee et al. establish developmental endothelial locus-1 as a key osteoclast-derived coupling factor that drives new bone formation in ankylosing spondylitis. Learn more: doi.org/10.1016/j.diff…
Fig. 1. DEL1 is highly expressed and secreted during osteoclast differentiation.
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Differentiation Journal@Diff_Journal
Jun 10
Findings from Rogério Salinas Ferreira et al. provide insights into resveratrol-induced osteogenesis and support its potential as a bioactive modulator of osteogenic pathways in periodontal ligament mesenchymal cells for bone regenerative therapies: doi.org/10.1016/j.diff…
Fig. 6. Proposed model of the IHH signaling pathway modulation by RAB23-GDP, -GTP and -Resveratrol molecular interactions. The rendered images represent the functional state of RAB23 protein (active or inactive) according of molecular docking with GDP, GTP and Resveratrol, and its impact in the IHH gene transcription (promotion or inhibition) induced by GLI1 transcription factor, in l-PDLCs cultivated in osteogenic medium with and without resveratrol pretreatment (OM and OM/RESV groups, respectively).
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