🧨💥Our latest work is out @cellreportsmedicine! We uncovered #p38MAPK mediated #proliferation stress as the culprit of functional #impairment of #HSC during exvivo #gene #editing. p38 inhibition endows edited HSC with high #clonal #output and better preserved genome #integrity!

We thank @martakova and @MateMaus for sharing their research with our community at yesterday's seminar!
Our next seminar on Tuesday, May 6th will feature Anna Kajaste-Rudnitski and Raphael Ceccaldi.
Subscribe here to receive the reminder: forms.gle/HfTaFCyFicCFYN…

1/2 We are very excited to announce the 10th Annual ICSA Meeting, which will take places in Rome, Italy on Sept 17th-19th, 2025.
Registration is now open! Visit our website for details:
icsa2025rome.com
We look forward to seeing you in Rome!

📢Thrilled to chair with #MassimoLopes the next series of virtual seminars from the #GenomeIntegrityItalianNetwork. We will cover a wide range of topics spanning from #genomeinstability, #senescence, #DDR, #metabolism, #epigenome maintenance and more!Join us and spread the word👇

Our next GiiN webinar will feature Lumír Krejčí from @muni_cz and Giulia Bastianello from @IFOMresearch. Join us on Tuesday, February 4th from 5-6 PM Rome Time for a lively discussion on genome integrity maintenance here: uniroma1.zoom.us/j/95149984403

1/7 Excited to share our team’s first paper revealing how senescent cells use the GD3 ganglioside as a Senescence Immune Checkpoints (SICs) to bypass immune surveillance published in @NatureAging ! rdcu.be/d4XXJ

Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system. nature.com/articles/s4358…

If you are interested in senescence, ageing and age-related diseases, you can apply for Postdoc and PhD Fellowships in my lab. I´ll help you with the application! Calls close end Jan 2025!
Happy holidays!!!

1/ 🚨New paper on ecDNAs from our lab!

We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in!
🧵👇
nature.com/articles/s4158…

We are deeply thankful to all the speakers for sharing their amazing finding with the GIIN community.
We also thank a lot our community for attending and stimulating fruitful discussions!

We wish you all a wonderful festive season.

See you all in January!

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations go.nature.com/3D2e4Fh

Now Online: Telomere function and regulation from mouse models to human ageing and disease go.nature.com/3D2Cu1m

The last GiiN seminar of 2024 is coming soon and you don't want to miss it!!

🗣️Speakers: Ivan Marrazzi and @DiMiccoLab
🗓️When: next Tuesday (Dec 3rd), 5pm Rome - 11am NYC
📍Where: Zoom uniroma1.zoom.us/j/95149984403

Thrilled to share the results of our 8-year-long expedition into the Wild, the city of #NYC , the wild west of #LosAngelesCA , and more—in search of the roots of gut fungal commensalism! 🧵nature.com/articles/s4158…

Are you all excited for NRMCB's newest ✨Focus✨ on
#CellSenescence? We have two Reviews AND an Expert Recommendation alongside a Tools of the Trade and eight (8!!) Journal Club articles for you - one of which highlights Judith Campisi's pioneering work.

nature.com/collections/id…

Andrea Carpinteiro is the
@IMMERGE_MSCA_DN Doctoral Candidate nr.6! 🎉🎉🎉

🔎Visit our website to know more:🤩

👩‍🔬 DC6: immergeproject.eu/researchers/ca…
👩‍🔬Supervisor: immergeproject.eu/supervisors/ra…
🇮🇹Project 6: immergeproject.eu/projects/06/

🔬@MSCActions
🇪🇺@EU_Commission
#DoctoralNetwork
#Immunology

This study was brilliantly led by a 💥 graduate student @dellaVolpe_L now a postdoc in Vijay Sankaran @bloodgenes lab (watch out for her outstanding work over there as well!), and brought to completion by twitterless students Fede and Roby. Perseverance and teamwork always payoff

It truly takes a village! Thanks to everyone else who contributed and to our funding agencies @ERC_Research @nyscf @HFSP @AIRC_it @Telethonitalia @MinisteroSalute. Looking forward to move these findings into innovative gene editing applications!