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Alterations in the stratum corneum (SC) ceramide profile might be an underlying factor in the impaired barrier function in #MycosisFungoides (MF). So, researchers characterized #BarrierFunction and SC ceramide profiles in lesional and non-lesional skin of patients with essed how these barrier and ceramide characteristics evolve during chlormethine gel treatment. 🧴

Abstract 🔗 bit.ly/4e6Cygz

🥼 Scientists from @uno_chapeco indicate that the biological effects of pharmacological #melatonin extend beyond mitochondrial dysfunction and involve remodeling of extracellular nucleotide metabolism, providing new evidence for an interaction between melatonergic and purinergic
📖 Read more in their #OpenAccess article: bit.ly/4zSWCLE.

📢 New review in @ActaBio: Scientists establish a pathology-guided framework linking six major pathological barriers to the rational design of nanoparticle–hydrogel microneedles for #alopecia.

🔗 bit.ly/4yFzq2A

Using skin as a clinically relevant model, Gabriel Batzli, Sarah Kleb, Drs. Stephenie Droll, and Brett Shook discuss how single-cell #RNASeqencing has advanced our understanding of mechanisms that regulate inflammation after injury.

📖 Read the review: bit.ly/4jAvP1Z

🚨 Researchers from @Westlake_Uni and @CAS__Science elucidate the coordinated spatiotemporal interplay of fibroblasts during #WoundRepair and spur novel therapeutic modalities and interventions for cutaneous healing.

Read more in @CellStemCell 👉 bit.ly/4i7nn7R.

This study, led by co-first authors Jinmin Ye, Wenhao Li, and Yatong Qin, presents a dual-action microneedle therapy for #psoriasis that alleviates psoriasis by modulating #keratinocyte ferroptosis and scavenging cell-free DNA to restore inflammatory #homeostasis. SBZ

📢 Researchers introduced a matrix metalloproteinase-9 (MMP-9)-responsive protein release system offering a precise, adaptive therapeutic strategy for #DiabeticFootUlcer. This system holds promise for other MMP-related diseases!

🔗 bit.ly/4dvZwgN

In @sigtrans_sttt, this review provides a systematic overview of the epidemiology, risk factors, diagnostic classifications, and comorbidities associated with acne.

#OpenAccess: go.nature.com/4yM3VEG

Findings from a new study establish recombinant humanized type III #collagen as a structurally defined and reproducibly produced collagen-like #biomaterial with promising potential to support early repair of acute UV-induced #skin injury.

Congratulations to first authors Yi Xie 1909, and their team!

Read the paper here: bit.ly/4hLV3rp

Researchers from @CUHKofficial introduced an MMP-9-responsive protein release system as a precise, adaptive therapeutic strategy for #DiabeticFootUlcer. 👣

Read the #OpenAccess article published in Advanced Science (@AdvPortfolio): bit.ly/4dvZwgN

Though kallikrein 5 (KLK5) overactivation is known to contribute to several inflammatory skin disorders, research findings from @CincyChildrens demonstrate that complete loss of KLK5 is also pathogenic in atopic dermatitis-like responses in mice.

Read the #OpenAccess paper here: bit.ly/4yBGj5P

#AD #AtopicDermatitis #Inflammation

This review highlights how #secretome-derived therapies offer a scientifically robust and clinically viable approach for restoring regenerative 🌱 competence in aged skin.

Learn more: bit.ly/4z2tVve | #OpenAccess

Dr. J. Michelle Kahlenberg and investigators used cutaneous UVB photoexposure ☀️ of healthy controls and patients with #SystemicLupusErythematosus to provide an atlas of the cutaneous inflammatory response 24 hours after UV exposure in single-cell resolution.

🔍 bit.ly/3TgjZPP

🔆 New study published in @CellReports links enhancer co-occupancy by p63/p73 to signaling and tumor maintenance in skin #SquamousCellCarcinoma.

👓 Read the #OpenAccess article: bit.ly/4iTIvk2.

Dr. Mariko Chikuma and researchers identified #TRPV4 ⚡as an important mediator of #epidermal responses to low-humidity stress 🏜️ , providing a molecular basis for low-humidity-driven signaling in the mammalian epidermis.

👉 bit.ly/4hKIbDa

#OpenAccess

This review will provide a comprehensive overview of piezoelectric biomaterials for skin wound healing 🩹 and examine the physiological and biochemical roles of the naturally occurring electric fields in healthy skin and injured skin.

Check it out: bit.ly/4cTAKa8

Researchers revealed significant activation of the TCA cycle 🔄 and identified α-ketoglutarate as a central regulator orchestrating the reparative phase. 🩹

Learn more here:
bit.ly/4y2qTqM

#OpenAccess

Researchers identified GLS1-mediated #glutaminolysis as a metabolic program preferentially induced in #keratinocytes under type 3 inflammatory🔥conditions.

Check it out: bit.ly/4j8b0dP

Researchers identified terminal epidermal differentiation-associated RNA as an important regulator of terminal #epidermal differentiation and suggest that its suppression may contribute to disturbed differentiation in inflammatory and neoplastic skin diseases.

🔎Learn more: go.nature.com/4A7Btyd #OpenAccess

Dr. Jiangang Feng and researchers including Xiaoyu Zhang suggested that the FOXQ1/SSBP2 regulatory axis plays a critical role in #melanoma progression and may serve as a potential therapeutic target 🎯 to improve melanoma treatment outcomes.

👉 bit.ly/4xf9zhb
#OpenAccess