First preprint of the @fordycelab and @Dunn_Lab collaboration! We used high-throughput microfluidics for sequence-strength mapping at the single-molecule level. Our new tech allowed us to discover a fundamental nonequilibrium property of multivalent systems. 1/13

Excited to share our Science Advances paper introducing Tether Force Spectroscopy: flow-stretched DNA "sails" that pull on molecules and read out single-molecule behaviour by fluorescence. No beads. Huge thanks to Adam, Ryan and the team. science.org/doi/10.1126/sc…

Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)

Many experiments in biology happen one protein at a time, which means synthesizing DNA one gene at a time. This is fine for tens of genes. For thousands, the cost is unsustainable.

Introducing uSort-M: a method to isolate and sequence-verify thousands of genes at low cost

New preprint alert - 5 years in the making! Using high-throughput microfluidic enzyme kinetics, we profiled 190 clinical variants of SHP2, a phosphatase linked to developmental disorders & cancer (1/8)
biorxiv.org/content/10.648…

@Stanford_ChEMH, @czbiohub, @bioe_stanford

To learn more, you can find our new preprint here! 12/13

biorxiv.org/content/10.648…

This work wouldn’t be possible without support of my thoughtful co-advisors @fordycelab and @Dunn_Lab , their creative labs, generous funders @StanfordBioX @NSF @NIH @Stanford_ChEMH @czbiohub , and my amazing co-authors! 13/13

I am excited to share our latest work on creating the first tunable Catch-Bond with #DNA! Our Fish-Hook architecture allowed precise control of adhesion nanomechanics, creating new possibilities for bioengineering and material science! 🧬🐟🪝🌟nature.com/articles/s4146… #biophysics

Interested in intrinsically disordered proteins or transcription factor activation? Or purifying & measuring affinities for 1000s of protein/protein interactions? Check out @nicole_delrosso & Peter Suzuki's preprint (w/ @BintuLab & @alexholehouse) shorturl.at/jEneh (1/n)

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