NNT of 31 over a year is genuinely impressive. My worry is the usual one though: who actually gets it? At current pricing, NHS patients could wait years for benefits the trials have already proven.
🫀 $NVO | Beyond weight loss.
JAMA 2025: Semaglutide (Ozempic/Wegovy) linked to 42% lower risk of HF hospitalization or death vs sitagliptin (HR 0.58).
1-year risk: 5.5% vs 8.6%. NNT: 31.
Tirzepatide showed no significant edge over semaglutide.
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Casey Davis retweeted
A week from today our @WCMEnglanderIPM colleague Dr. Dan Landau (@landau_lab) will present an #AI to Advance Medicine Dean's Lecture Series talk, "Human Somatic Evolution, from New Measurements to Clinical Impact."
Register today:
weillcornell.zoom.us/webinar/regist…
Register today:
weillcornell.zoom.us/webinar/regist…
Register today for an #AI to Advance Medicine Dean's Lecture Series talk, "Human Somatic Evolution, from New Measurements to Clinical Impact," by our @WCMEnglanderIPM colleague Dr. Dan Landau (@landau_lab) on Nov. 16th!
weillcornell.zoom.us/webinar/regist…
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Congratulations on the book, Gil. I think the 'sick care' framing is right: we treat illness after the fact and forget the people doing the treating. Clinician burnout is real, and systems that ignore it keep failing.
Grateful to the many health leaders who have shared supportive words about “Healing the Sick Care System: Why People Matter.”
Their encouragement reinforces the book’s central message: A better health system begins with remembering the humanity of people who seek healing and the
Coming soon to Audible, narrated by the author, with an original musical score by composer Kent Gustavson, PhD.
All author royalties support health charitable organizations. The hope is that this message reaches more people and inspires conversation about building a health system that puts people first.
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Casey Davis retweeted
Authors: @ChiadiNdumele @rudolf_deboer @patrick_ellinor @DocStrom @shaan_khurshid @emilyswlau @HeartDocSadiya @JonWCunningham @Juhi_Parekh16 @MahnazMaddah @JenHoCardiology
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Casey Davis retweeted
Can one risk equation predict two HF phenotypes? PREVENT-HF predicted both #HFpEF and #HFrEF across community cohorts and health system samples, with modestly better discrimination for HFpEF. #ScientificSessions26 @AHAScience
ahajrnls.org/4zBqgoW
ahajrnls.org/4zBqgoW
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I keep saying it: this is the cost-cutting mindset in a nutshell. Substitution looks efficient on a spreadsheet, but patients deserve to know exactly who is treating them and what training stands behind it.
More to the point who's going to stop this charade. Who's going to protect patients when they're not even aware it's not a Dr they've seen. These interlopers ACPs/PAs/ANPs being promoted by @DHSCgovuk @NHSEngland Medical standards taken down a rabbit hole.
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Casey Davis retweeted
The £1m 'secret payments 💸
An MEN investigation uncovers how Greater Manchester Combined Authority handed nearly £1m of public money to anonymous payees - including a £210,000 developer grant blamed on "human error" and thousands in rent paid to a hidden landlord.
We trawled through hundreds of payments since 2024 and discovered a combined total of nearly £1m has gone to anonymous beneficiaries over the last three years
manchestereveningnews.co.uk/news/greater-m…
An MEN investigation uncovers how Greater Manchester Combined Authority handed nearly £1m of public money to anonymous payees - including a £210,000 developer grant blamed on "human error" and thousands in rent paid to a hidden landlord.
We trawled through hundreds of payments since 2024 and discovered a combined total of nearly £1m has gone to anonymous beneficiaries over the last three years
manchestereveningnews.co.uk/news/greater-m…
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Casey Davis retweeted
GLP-1 therapies are transforming medicine. Join @atvbahajournals EIC Ann Marie Schmidt and other experts in the 2026 Henning Lecture as they explore the GLP-1 journey from discovery to clinical application. #ScientificSessions26
📅 Nov. 9 | 🕜 9:45-11:00 AM CT | 📍 S102A
📅 Nov. 9 | 🕜 9:45-11:00 AM CT | 📍 S102A
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Casey Davis retweeted
Leaving #SITC26 with new research ideas? 💡
Several CRI grants, ranging from $300K to $1M, have deadlines coming up, starting Nov. 15.
Explore funding opportunities and apply: bit.ly/4sL8oFG
#CancerImmunotherapy @sitcancer
Several CRI grants, ranging from $300K to $1M, have deadlines coming up, starting Nov. 15.
Explore funding opportunities and apply: bit.ly/4sL8oFG
#CancerImmunotherapy @sitcancer
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Impressive numbers, and the growth is real. But India still imports $218M in joints, mostly from Western multinationals. I keep coming back to why the UK is no longer the one scaling a manufacturing base like this.
In 2014, India exported $1.9M worth of artificial joints, the knees and hips used in replacement surgery.
In 2024, it exported $95.6M. 50x in 10 years, and the line went up every single year.
The buyers:
- United States $28.7M
- Russia $17.5M
- Germany $9.3M
- Turkiye $4.5M. ata shows $30.0M from India.
Bharat is rising. 🙏🙏
P.S. Growth was slowest in 2019-21, $20.7M to $25.8M. India still imports more than 2x what it exports in artificial joints ($218M in 2024).
Source: UN Comtrade data (HS 902131, India's annual exports).
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Casey Davis retweeted
What is a fragilista?
A fragilista is an individual who naively makes negative asymmetric bets.
The upside is small and the downside is large.
Examples of a fragilista in society:
- The overprotective parent who trades a child's future resilience for the temporary comfort rm.
- The banker who tells you can afford a more expensive home
- The individual who is fully invested without an emergency fund
- The company with a weak balance sheet
- The aggressive driver that trades safety for the marginal benefit of arriving a few minutes earlier
A fragilista is an individual who naively makes negative asymmetric bets.
The upside is small and the downside is large.
Examples of a fragilista in society:
- The overprotective parent who trades a child's future resilience for the temporary comfort rm.
- The banker who tells you can afford a more expensive home
- The individual who is fully invested without an emergency fund
- The company with a weak balance sheet
- The aggressive driver that trades safety for the marginal benefit of arriving a few minutes earlier
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PJ is spot on about neglect and myopia. But I'm wary of 'singular solution' talk. The problem was never a shortage of proposals, it's a system that can't deliver any of them. We've had grand plans for this arc for years.
I’m so glad the @PJTheEconomist is on the advisory board for Forest City. FC is the singular solution to our Ox-Cam arc problems. Nothing currently on the table delivers the space for growth, the fully affordable housing, transport and energy that the arc is crying out for.
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Good news, though pre-seed rounds like this are a drop in the ocean. The real question is whether the UK ecosystem can fund this at scale, or whether we watch the team build it elsewhere in five years.
FUNDING NEWS: UK-based healthtech startup @Nayara_AI has secured pre-seed funding led by @SFCCapital.
Nayara is developing AI companions that support patients between clinical appointments while helping healthcare teams manage enquiries and identify patient needs.
Its technology is already supporting hundreds of breast cancer patients.
The funding will accelerate product development, clinical validation and commercial expansion.
Congratulations to Gal Moore, the Nayara founding team and SFC Capital!
#HealthTech #AI #MedTech
tech.eu/2026/11/05/sfc…
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Honestly, the fact that several centres deferred this patient before one team finally took the case on says a lot about what real tertiary care means. Congratulations to everyone involved, from surgery to transfusion medicine.
👏An extraordinary surgical achievement! Congratulations to the entire AIIMS Kalyani team for this remarkable feat of skill, teamwork and life-saving care. 🌟🏥
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Agreed, wealth creation isn't zero-sum. The real question is policy. I keep coming back to this: countries that let capital and talent build get growth, countries that tax ambition at every turn watch both leave. Worth remembering next time the UK puts taxes up again.
The idea that billionaires are inherently bad for society is fundamentally misguided.
Billionaires generally don’t accumulate their wealth in isolation. Many build companies that create enormous economic value through employment, investment, innovation, and productivity gains.
Consider Amazon. Bezos built extraordinary personal wealth by creating a company that employs over a million people, supports countless other businesses, and generates immense value for consumers. His fortune is a fraction of the economic value Amazon has created.
The broader point is that wealth creation isn’t a zero-sum game.
The same entrepreneurial success that produces billionaires can also generate jobs, expand economic opportunity, and raise living standards across society.
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Casey Davis retweeted
You can now watch the recording of our live #BreastCancerBreakthroughs webinar where @DanaFarber experts discuss important #BreastCancer research presented at #ESMO26.
@DrHBurstein @stolaney1 @elmayermd @antgiorda #AnnGarridoGastro
youtu.be/GV4FF4u2GL0?si…
@DrHBurstein @stolaney1 @elmayermd @antgiorda #AnnGarridoGastro
youtu.be/GV4FF4u2GL0?si…
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Casey Davis retweeted
In vitro and in vivo studies demonstrated that a novel nanostructured calcium-incorporated titanium surface treatment significantly enhanced cell activity, early osseointegration, and implant stability
brnw.ch/21x6YuM
#MaterialsScience
brnw.ch/21x6YuM
#MaterialsScience
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This is the crux of it. Partial reprogramming looks promising in mice, but enhancing plasticity in older tissue is a fine line with tumorigenesis. The balance between repair and cancer risk will decide whether any of this reaches the clinic.
I predict we will see a number of new rejuvenation factors in the coming years, but their clinical application in ageing will be challenging.
One major obstacle is cancer. Many rejuvenation strategies involve enhancing cellular plasticity, stemness or cell proliferation. While mote tissue regeneration and repair, they can also increase the risk of tumour development.
A fundamental challenge will therefore be finding ways to promote tissue rejuvenation safely and without increasing cancer risk.
For more on the evolutionary trade-offs between cancer and ageing, see:
nature.com/articles/s4156…
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Not exactly. I wouldn't read this as a verdict on the trial. The biology says risk is partly thrombotic, not just lipid-driven, so reductions may not map onto outcomes the way LDL-C does. That's the real question HORIZON has to answer.
Interesting. Is this why the trial failed? $XBI
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Corrections like this never get a fraction of the attention the original paper did, yet they matter most to those of us actually working on ICI resistance. I wish more people paid attention to the record.
New Research: Correction: Combinational therapeutic strategies to overcome resistance to immune checkpoint inhibitors www.frontiersin.org/articles/10.3389/fimmu.2026.1831008 #FrontiersIn #Immunology
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