Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain: cell.com/cell-reports/f…

Identification of candidate markers for the isolation of neuron-specific extracellular vesicles
nature.com/articles/s4159…

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue
alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue
alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue: nature.com/articles/s4146…

The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy biorxiv.org/content/10.648…

Great to be part of #ALSNexus26 last week! I presented our work on modulating extracellular vesicles to inhibit dipeptide repeat propagation in C9-ALS, both in the Emerging Science session and as a poster.

Great discussions across the ALS community. #ALS

Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer’s Disease Mouse Model
link.springer.com/article/10.100…

Distinct brain extracellular vesicle microRNA
profiles differ in frontotemporal dementia and
Alzheimer’s disease
academic.oup.com/braincomms/art…

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation
nature.com/articles/s4200…

TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain
medrxiv.org/content/10.648…

The UNC13A cryptic exon associateswith cognitive impairment in Alzheimer’sdisease
link.springer.com/article/10.118…

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets
researchsquare.com/article/rs-100…

NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a Drosophila tauopathy model
sciencedirect.com/science/articl…

TBC1D9 and TBC1D9B are ARL8 effectors that modulate exosome secretion through a RAB11A–exocyst pathway
pnas.org/doi/full/10.10…

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease
nature.com/articles/s4159…

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
science.org/doi/10.1126/sc…

Cell-type signatures of Alzheimer’s disease shared across population groups
nature.com/articles/s4158…

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior biorxiv.org/content/10.648…

A new study profiled tau inside human brain-derived vesicles: the PHF6 (VQIVYK) motif is the seeding-compentent cargo. Blocking PHF6 could be a way to stop tau pathology in its tracks.
link.springer.com/article/10.118…