Excited to share our work with @DjuranovicLab on bioRxiv, introducing RAPPL-Seq! 🧬
doi.org/10.64898/2026.…
#RNA #RiboSeq
doi.org/10.64898/2026.…
#RNA #RiboSeq
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@DjuranovicLab Most excitingly, RAPPL-Seq enables translatome profiling from tiny human biopsies (<1 mg), including glioblastoma and adjacent non-tumor brain tissue. We also identified tumor-enriched translation signatures, opening new ways to study translational regulation in human diseases!
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Key advances:
⚡~16× more RNA from 20× fewer cells
⏱️ Isolation in <3 hours
🔬 High-quality profiling from as few as 200K cells
⚡~16× more RNA from 20× fewer cells
⏱️ Isolation in <3 hours
🔬 High-quality profiling from as few as 200K cells
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Most excitingly, RAPPL-Seq enables translatome profiling from tiny human biopsies (<1 mg), including glioblastoma and adjacent non-tumor brain tissue. We also identified tumor-enriched translation signatures, opening new ways to study translational regulation in human diseases!
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We are so back! We have new faces, data, and upcoming publications in the Chen Lab at WashU Med. Accepting DBBS rotation students for the upcoming school year! Stay tuned for cutting edge circRNA and ribosome profiling research🧬
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Heads up! CK will be attending the Post-Transcriptional Gene Regulation Gordon Research Conference from July 20-23 in Portland, Maine. He'll be presenting a poster on the latest research going on in his lab. Make sure to check it out!
#academicresearch #rnabiology #circRNA
#academicresearch #rnabiology #circRNA
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Chun-Kan Chen retweeted
Together with Chun Kan Chen's and @slavicaPD groups we have recently optimized our RAPPL method for the isolation of ribosomes and ribosome fragments from biopsies (5-10mg), tissues (1-5mg) and small blood samples (100-500ul). Soon more on RAPPL Ribo-Seq...
Images from ribosome blood, RAPPL-RiboSeq reads and comparison of low expression genes with RAPPL RiboSeq on 250K cells with 10 million cells with classical method. Pending patent #63/694,196 (WU Ref No. 020910/US)
nature.com/articles/s4146…
Images from ribosome blood, RAPPL-RiboSeq reads and comparison of low expression genes with RAPPL RiboSeq on 250K cells with 10 million cells with classical method. Pending patent #63/694,196 (WU Ref No. 020910/US)
nature.com/articles/s4146…
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Guess who happens to be traveling today from GRC when Windows is down...spent whole day among different airports with flight delayed or canceled...
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Glad to be at the GRC RNA conference: Post-transcriptional Gene Regulation. Had great discussion with many talented RNA scientists! Perfect weather for a boat tour as well!
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Want to learn more about circular RNAs and immunity? Come join our CB&P Seminar tomorrow (April 1st) at 1:00 PM!
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Glad to receive The Young Investigator Award from The Cancer Research Foundation! Thanks for the insights and help from @StratmanLab @sastewartlab and Milan Chheda. Excited about the applications of circRNAs in cancer treatment!
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Thrilled to be nominated to be featured in the RNA Society Spotlight Series (rnasociety.org/chun-kan-chen-…)! Thanks to Julieta Rivosecchi @jurivosecchi and The RNA Society @RNASociety for this incredible opportunity to share my work and my journey in RNA research!
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Want to learn more about the exciting discoveries in circRNA? Come to our CBP Seminar Series next Tuesday (Feb 6th)!
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