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🎙️Excited to announce the website for Ring That Bell 🔔 which I co-wrote w internationally acclaimed Irish country music artist @mags__mccarthy. It tells the emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer cerresearch #immunotherapy #hope
ringthatbellsong.com
ringthatbellsong.com
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GD2 is widely recognized as a target in neuroblastoma, but remains underappreciated in sarcoma.
Pleased to be a coauthor of this new study demonstrating that GD2 CAR T cells effectively kill Ewing sarcoma cells in 2D and 3D models, including cells with low GD2 expression, and infiltrate tumors and suppress growth in vivo. Led by @giugolli @massdomi & colleagues
Pleased to be a coauthor of this new study demonstrating that GD2 CAR T cells effectively kill Ewing sarcoma cells in 2D and 3D models, including cells with low GD2 expression, and infiltrate tumors and suppress growth in vivo. Led by @giugolli @massdomi & colleagues
#EwingsSarcoma (ES) is an aggressive cancer for which effective treatment options remain a significant unmet medical need.
💡 This new @cddpress article supports the efficacy of GD2 CAR T cells against both in vitro models and a localized in vivo model of ES!
🔗 go.nature.com/4AdWUNj
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With GD2, reports of on target off tumor toxicity are of concern. Designing CARs against OAcGD2 may open an avenue for safer targeting of this solid tumor antigen.
biorxiv.org/content/10.648… Others are pursuing this angle as well.
biorxiv.org/content/10.648… Others are pursuing this angle as well.
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The Misinformation Virus is killing paople
theguardian.com/technology/202…
theguardian.com/technology/202…
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Congratulations to @kiranmusunuru & @AhrensNicklas for not only pioneering individualized gene editing for Baby KJ, but also helping shape the regulatory pathway for the patients who will follow, with implications far beyond one patient or one disease.
The FDA's new draft guidmportant advance, recognizing that multiple patient-specific variants of a gene-editing therapy can be evaluated within a common regulatory framework, while maintaining rigorous standards for safety and efficacy.
This is how science and regulation should work together.inquirer.com/health/fda-gui…
The FDA's new draft guidmportant advance, recognizing that multiple patient-specific variants of a gene-editing therapy can be evaluated within a common regulatory framework, while maintaining rigorous standards for safety and efficacy.
This is how science and regulation should work together.inquirer.com/health/fda-gui…
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Individualized Human Genome Editing Products: Considerations for BLA Submission and Postapproval Management #FDA fda.gov/regulatory-inf…
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweeted
If you ever needed the data to show what happens when vaccine disinformation spreads and trust in science is undermined - here it is.
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RT @ScottGottliebMD: We're reporting only a fraction of measles cases in the US; some estimates put it as low as 20% in states like PA. Thi…
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America Votes, China Plans
China sets out its stall for global biopharmaceutical preeminence as the US faces further uncertainty over research funding and regulation @medicine_maker themedicinemaker.com/issues/2026/ar…
China sets out its stall for global biopharmaceutical preeminence as the US faces further uncertainty over research funding and regulation @medicine_maker themedicinemaker.com/issues/2026/ar…
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☝️@medicine_maker China is pursuing a coordinated, long-term strategy to become a global leader in biopharmaceutical innovation, while the United States risks eroding its competitive advantage through unpredictable research funding, regulatory uncertainty, and fragmented policy.
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The biotech China question @statnews The answer isn't isolation. It's investment in American science and innovation. We cannot afford to surrender leadership in the industries that will define the future of medicine. statnews.com/2026/05/18/bio…
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweeted
You cannot fire scientists, halt ongoing research and clinical trials, drive away the next generation and then declare a “golden age” of American science. These cannot fundamentally coexist.
As we head into the elections here is a breakdown breakdown of the damage done to the tem so far:
Defense research labs lost roughly 14% of their staff. The Pentagon itself warned of “potentially grave consequences for the future of national defense.”
NIH staffing fell by 1/5. More than 2,000 biomedical research grants were delayed or canceled, affecting work on cancer, Alzheimer’s and other major diseases affecting the health of American public.
HHS announced a wind-down of mRNA vaccine development at BARDA, affecting 22 projects worth nearly $500 million through cancellations, cuts and restructuring and halting new mRNA projects under the program.
The National Science Foundation lost roughly 1/3 of its staff and withheld more than $1 billion in funding.
The Energy Department lost more than 1,000 scientists and technical staff. Grant awards from its two major science offices fell by more than $500 million during the administration’s first year.
NASA lost 20% of its employees with Ph.Ds.
Foreign Ph.D. applications at leading universities fell 21%. Schools reduced admissions as funding uncertainty made it harder to support future scientists and removing a pathway for sustaining scientific excellence globally.
Meanwhile, a proposed rule would give political appointees greater control over who receives research funding, screening applications for supposedly “anti-American values.”
Thankfully Congress rejected the massive proposed budget cuts and courts forced funding restorations. But neither can replace the time and investment already made. We can’t just simply flip the switch back on.
And while the federal government can still spend roughly $200 billion on research - we continue to witness the dismantling of the capacity to turn funding into discovery.
And make no mistake - other countries are happy to step in - including China - who are recruiting the talent we are losing.
The treatments we will need in 20 years depend on the research we conduct today. So do our security, our prosperity and our ability to maintain our lead globally.
Vote tomorrow because science depends on it.
As we head into the elections here is a breakdown breakdown of the damage done to the tem so far:
Defense research labs lost roughly 14% of their staff. The Pentagon itself warned of “potentially grave consequences for the future of national defense.”
NIH staffing fell by 1/5. More than 2,000 biomedical research grants were delayed or canceled, affecting work on cancer, Alzheimer’s and other major diseases affecting the health of American public.
HHS announced a wind-down of mRNA vaccine development at BARDA, affecting 22 projects worth nearly $500 million through cancellations, cuts and restructuring and halting new mRNA projects under the program.
The National Science Foundation lost roughly 1/3 of its staff and withheld more than $1 billion in funding.
The Energy Department lost more than 1,000 scientists and technical staff. Grant awards from its two major science offices fell by more than $500 million during the administration’s first year.
NASA lost 20% of its employees with Ph.Ds.
Foreign Ph.D. applications at leading universities fell 21%. Schools reduced admissions as funding uncertainty made it harder to support future scientists and removing a pathway for sustaining scientific excellence globally.
Meanwhile, a proposed rule would give political appointees greater control over who receives research funding, screening applications for supposedly “anti-American values.”
Thankfully Congress rejected the massive proposed budget cuts and courts forced funding restorations. But neither can replace the time and investment already made. We can’t just simply flip the switch back on.
And while the federal government can still spend roughly $200 billion on research - we continue to witness the dismantling of the capacity to turn funding into discovery.
And make no mistake - other countries are happy to step in - including China - who are recruiting the talent we are losing.
The treatments we will need in 20 years depend on the research we conduct today. So do our security, our prosperity and our ability to maintain our lead globally.
Vote tomorrow because science depends on it.
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Unproven cell therapies are not just a threat to patients. They threaten the entire field.
Clinics selling unproven, unregulated cell therapies exploit patient hope, expose patients to serious harm, undermine public trust, and divert patients from legitimate clinical trials.
Regulatory oversight is not the enemy of patient access. It is essential to demonstrating safety and efficacy. The cell therapy community must do more than condemn bad actors. We need better patient communication, stronger enforcement, rigorous clinical evidence, and sustainable access to treatments that work.
Clinics selling unproven, unregulated cell therapies exploit patient hope, expose patients to serious harm, undermine public trust, and divert patients from legitimate clinical trials.
Regulatory oversight is not the enemy of patient access. It is essential to demonstrating safety and efficacy. The cell therapy community must do more than condemn bad actors. We need better patient communication, stronger enforcement, rigorous clinical evidence, and sustainable access to treatments that work.
Unproven, unregulated cell therapies continue to pose risks to patients and challenges for the field.
This Cytotherapy article examines the issue and proposes a framework for clearer, more consistent terminology.
🗒️ Read more: buff.ly/BRJxRys
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Dismantling America’s Scientific Research Machine Disables America's Global Leadership nytimes.com/2026/10/31/cli…
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Dismantling America's scientific research engine means cures not developed, makes America weaker and less resilient in many ways
National Security: Pentagon research labs have lost 14% of their staff. The Defense Department warns of grave consequences for national security. Scientific expertise underpins our military superiority. Losing it puts America at risk.
Competition With China: China is closing the gap in scientific research while America loses scientists and research funding. Foreign Ph.D. applications are down 21%. Scientific leadership is a strategic asset that could take decades to rebuild.
Taxpayer Investment: America invests $200 billion annually in federal research. Canceling grants, disrupting experiments, and losing scientists wastes years of taxpayer-funded work. Fiscal responsibility means protecting that investment.
Medical Breakthroughs: Cancer immunotherapy, gene therapy, and modern medicines emerged from decades of federally funded research. More than 2,000 NIH grants have been delayed or canceled. Today's cuts threaten tomorrow's cures.
American Jobs: University research drives biotechnology, startups, patents, and high-skilled jobs. As grants disappear and scientists leave, other nations recruit our talent. America risks handing its competitors the next generation of breakthroughs.
American Leadership: Eight decades of bipartisan federal research investment made America a global leader in medicine, defense, and technology. Scientific excellence isn't a partisan issue. It's fundamental to our security, prosperity, and future.
National Security: Pentagon research labs have lost 14% of their staff. The Defense Department warns of grave consequences for national security. Scientific expertise underpins our military superiority. Losing it puts America at risk.
Competition With China: China is closing the gap in scientific research while America loses scientists and research funding. Foreign Ph.D. applications are down 21%. Scientific leadership is a strategic asset that could take decades to rebuild.
Taxpayer Investment: America invests $200 billion annually in federal research. Canceling grants, disrupting experiments, and losing scientists wastes years of taxpayer-funded work. Fiscal responsibility means protecting that investment.
Medical Breakthroughs: Cancer immunotherapy, gene therapy, and modern medicines emerged from decades of federally funded research. More than 2,000 NIH grants have been delayed or canceled. Today's cuts threaten tomorrow's cures.
American Jobs: University research drives biotechnology, startups, patents, and high-skilled jobs. As grants disappear and scientists leave, other nations recruit our talent. America risks handing its competitors the next generation of breakthroughs.
American Leadership: Eight decades of bipartisan federal research investment made America a global leader in medicine, defense, and technology. Scientific excellence isn't a partisan issue. It's fundamental to our security, prosperity, and future.
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Genome editing holds tremendous promise. However, applications that could alter the genetic inheritance of future generations demand a higher standard of scientific evidence and technical and ethical oversight. The risks extend far beyond individual human embryos and raise profound societal questions that cannot be addressed by technological capability alone. #ethics #bioethics
This @FT article highlights growing investment in human #EmbryoEditing.
ISCT, alongside ASGCT and ARM, has called for a 10-year moratorium on heritable human genome editing to ensure responsible oversight.
Article: buff.ly/wmjf1Nb
Moratorium: buff.ly/9zAXUr4
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweeted
SCOOP: A Trump administration plan to give Americans easier access to unproven peptides was opposed by FDA drug staffers, who had limited input in drafting the policy.
apnews.com/article/peptid…
apnews.com/article/peptid…
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Today we launched the Inaugural @ISCTglobal Clinical Applications Program for Fellows @PennMedicine - A selective, ISCT-funded two-day immersive program equipping clinical fellows with practical skills to advance cell and gene therapies from bench to bedside. Links in reply and ourses
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@ISCTglobal The Global Leader in Cell & Gene Therapy Training isctglobal.org/workforce-deve…
isctglobal.org/workforce-deve…
isctglobal.org/workforce-deve…
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