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THIS EVERYDAY!
GRACIAS @sanbenito por hacer brillar esa monoestrellada como sólo lo sabes hacer tú!

Orgullosa hoy y siempre de ser Puertorriqueña! 🇵🇷❤️

@COlazagasti @Latinamd @barbarasegarra @ChocoDoc11
Lo único más poderoso que el odio, es el amor.

The Only Thing More Powerful Than Hate is Love. @sanbenito #AppleMusicHalftime
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
🙏The @IMG_Oncologists webinar on how to get involved in clinical trials was a huge success! Fantastic insights and discussions from @montypal @SPremji7866 @GIcancerDoc @royaryam from key concepts to practical applications. 💡 Key takeaways:
🔸Find a clinical niche that aligns patient population.
🔸Seek out dedicated, insightful mentors both within and outside your institution.
🔸Show your enthusiasm, say YES to opportunities
🔸Give yourself grace - Clinical trials take time!
🎥 Recording coming soon!
@DrChoueiri @ZiadBakouny @OncoAlert #MedEd #MedTwitter @OncBrothers @ASCOTECAG
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
Report on zongertinib and CNS disease in pts with advanced HER2 mutant NSCLC @JTOonline. In 4 cases, pts received escalated doses of zongertinib at 240mg with variable effect but one case was able to continue at the higher dose for 30 months.

jtocrr.org/article/S2666-…
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
#ESMO26 As the excitement around B7-H3 ADCs continues to grow, sharing this ESMO poster on Tam-Peli (tambotatug pelitecan, YL201) and ILD risk across tumor types. In 723 pts, ILD risk was 3% with no grade 4/5 cases. Median time to onset was 95 days and most resolved/resolving.
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
A true tour de force by the amazing @DrJNaidoo at #ESMO26 Presidential Symposium! 👏🔥

A masterclass in how to discuss a negative trial: sharp, insightful, and extracting every important message for our oncology community.

And doing it all while waiting for the new member of ul #WomenForOncology role model! Absolutely WOW! 🌟💪💪

#ESMO2026 #W4O @myESMO
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
#ESMO26 Highly recommend watching Dr. Tina Cascone in this lung education session for a mechanistic view of novel immunotherapy agents. Clear explanation of how function follows structure, the science behind bispecifics and trispecifics - combinatorial vs obligate. Watch online - anyone involved in the space. #ESMOAmbassadors
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
OptiTROP-Lung06 #ESMO26: 1L sac-TMT+pembro vs chemo-IO, PD-L1-neg nsq NSCLC
➡️ mPFS 15.0 vs 5.7 mo, HR 0.49
➡️ ORR 50.2 vs 47.3%, mDOR 13.6 vs 6.8 mo
➡️ OS HR 0.58, immature
➡️ G≥3 TEAEs 47.6 vs 60.6%
What must ADCs show to replace platinum?

@LungCancerRx @OncoAlert @oncodaily
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
A pleasure to catch up with so many terrific people at #ESMO26! @tompowles1, @DrChoueiri, @FedefedeFri, @alshamsi2000, @DrYukselUrun, @ProfSyedHussain, @ErikaHamilton9, @jrgralow, @MatteoSantoniMD, @chadinabhan, @OncHahn, @TiansterZhang, @AnaVManana - and that's just skimming truly takes a village & this meeting has brought so many drivers of progress under one roof!
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✨ PRACTICE CHANGING ✨ data from #ESMO26

Divarasib becomes the NEW Standard of Care for 2L KRAS G12C #LungCancer

@FSkoulidis presents results from Krascendo 1

Divarasib significantly prolongs PFS and OS with a more tolerable safety profile
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On Monday I told a patient with SCLC, this is the treatment plan today, but I’m hoping next week I can bring you better news from #ESMO26
👇 THIS is what we are here for!

🌟 PRACTICE CHANGING update for ES-SCLC: adding tarlatamb to maintenance durvalumab increases median OS by to @sands_jacob and to all the DeLLphi-305 investigators!

#ESMO26 #LCSM
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
#ESMO26 Presidential 1
Excellent state-of-the art discussion on #Dellphi-305 by the 1@only @StephenVLiu
emphasizing on:

➡️ 1L maintenance Tarla setting a new SoC with a mOS of>20 months
❓High attrition rate from induction to maintenance, need for earlier TCE ( Dellphi-312)
❌Onl arm received 2L Tarla post-progression reflecting access hurdles
✅ Global access to Tarla will make innovation meaningful for our patients
@@myESMO #ESMOAmbassadors
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
Because lung cancer has gifted me the most amazing onc brothers - talented, empathetic - rock stars!

Congrats @StephenVLiu for a perfect delivery, concise discussion and clinical relevant presentation at #ESMO26

And @g_mountzios for saving my seat the presidential w his life
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
Looking forward to the #ESMO26 Presidential Symposium! Exciting DeLLphi-305 data in ES-SCLC, presented by @JacobSandsMD, followed by what promises to be an insightful discussion from Dr. Stephen Liu @StephenVLiu Auditorium packed! #ESMO26
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INTerpath-001 adjuvant Intismeran Autogene + Pembro vs Pembro for resected stage IIB-IV #Melanoma

Impressive RFS and distant metastasis free survival improvement with a truly personalized and neoantigen-driven approach

@ProfGLongMIA #ESMO26
@myESMO
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
Great start to the day at #ESMO26 seeing so many of our brilliant friends! @NarjustFlorezMD @MartinReck2 @AnaVManana @JustinGainor @isla_dolores #ESMOAmbassadors
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👑 Updates on ctDNA data from the CROWN study, lorlatinib in ALK-fusion positive NSCLC at #ESMO26

🔹 TP53 mut. enriched on pts who experienced early progression
🔹 Baseline TP53 mut. associated with poor prognosis
🔹 Baseline detectable ctDNA and clearance at 4 and 24 wks M
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
It was an amazing surprise!

Gracias Totales!

#ESMO26
So happy to see my friend Dr. @NarjustFlorezMD honored by Dr. @Tony_Calles and @tactics_md at an #ESMO26 reception full of close friends.
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
El mejor futbolista de la historia.

Qué fotón.
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
#ESMO26 Dr. @LeXiuning discusses rapid oral abstracts on EGFR mutant NSCLC, surveying current landscape and refinement - can ctDNA be used to escalate care? Can we streamline supportive measures to reduce EGFR-related toxicity? #ESMOAmbassadors
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
First day at #ESMO26!
Exceptional international faculty @EnriquetaFelip, Dr. Antonio Passaro, @MARIANOPROVENCI and Maria Karen, exploring the many facets of NSCLC management, always keeping patients’ preferences at the heart of decision-making. Full house at #ESMO26!
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Ana I. Velázquez Mañana, MD, MSc, FASCO retweeted
You truly deserved it! ❤️ #ESMO26 The #LCSM community is much better with you!!! Keep going, amiga!! 💪
It was an amazing surprise!

Gracias Totales!

#ESMO26
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