Pinned Tweet
We bring together UCSF scientists and clinicians to uncover mechanisms behind aging, develop novel diagnostic/therapeutic tools, and establish best practices for providing equitable care to older adults in our communities. geroscience.ucsf.edu
0
5
27
BARI’s Diana Laird is part of the Tabula Sapiens Consortium behind a major Cell resource: an expanded single-cell atlas of 1.1million+ human cells across 28 tissues. Among the insights is how senescence looks different depending on cell type and tissue. bit.ly/4zoEngJ
1
0
2
260
Congrats to the new BARI/Hillblom Graduate Fellows! Since 2021, BARI/Hillblom has supported 35 graduate students across 13 programs. Excited to see the next gen of aging researchers thrive! geroscience.ucsf.edu/news/bari-hill…
0
1
7
371
Some patients with autoimmune lung disease develop progressive fibrosis that looks a lot like idiopathic pulmonary fibrosis. In a Thorax review, BARI’s Paul Wolters & team argue that different diseases can converge on shared fibrotic pathways, including age-related ones.
1
0
0
112
Bacteria have immune systems that kill infected cells to stop phage spread. In Molecular Cell, BARI’s Seth Shipman and colleagues show a non-canonical retron that only makes DNA when phage arrives, then uses that DNA to unlock translation of a toxin. sciencedirect.com/science/articl…
0
0
1
120
Exciting opportunity at UCSF!
The Department of Cell and Tissue Biology is recruiting a tenure-track Assistant or Associate Professor studying the cell biology of disease, with applications on the cell biology of aging especially encouraged!
The Department of Cell and Tissue Biology is recruiting a tenure-track Assistant or Associate Professor studying the cell biology of disease, with applications on the cell biology of aging especially encouraged!
1
5
13
2,553
Join a vibrant, collaborative community of researchers across the Parnassus campus. Apply by Dec 1: aprecruit.ucsf.edu/JPF06272 #FacultyJobs #UCSF #CellBiology #AgingResearch #Geroscience
0
0
2
156
BARI’s Guo Huang & colleagues identify Coq10a, a muscle-enriched mitochondrial protein as a regulator of postnatal heart growth. In PNAS, loss of Coq10a drives heart enlargement via altered coenzyme Q distribution and PPAR signaling, without hurting normal energy production.
1
2
6
263
New tools for phage therapy screening: BARI’s Seth Shipman reports Detectrons, which converts a detected RNA sequence into a durable DNA barcode. In Nature Biotechnology, they show multiplexed, live-cell detection of which phages infect bacteria. pubmed.ncbi.nlm.nih.gov/42834224/
0
0
1
120
BARI’s Aric Prather reports a small randomized trial of lemborexant for daytime sleep in night-shift workers. The drug didn’t beat placebo overall, but participants on the 10mg dose showed a signal worth testing in larger studies. link.springer.com/article/10.100…
0
0
1
119
BARI’s Dengke Ma reviews strategies to take on APOE4 in Alzheimer’s. The focus is restoring healthy cholesterol handling in the brain, with approaches that range from small molecules to antibodies and systemic lipid drugs. febs.onlinelibrary.wiley.com/doi/epdf/10.11…
0
0
0
86
When TBK1 doesn’t work well enough, cells struggle to clear waste and control inflammation. In this new review, BARI’s Daniel Mordes explains how this dual hit contributes to ALS and related dementias, and what it means for future therapies. frontiersin.org/journals/neuro…
0
2
5
218
Aging tissues get stiffer, and more fragile. In the Journal of Cell Science, BARI’s Hanna Martens & colleagues review how failed mechanotransduction, from matrix to nucleus, drives senescence & inflammation, and how resetting that niche might rejuvenate tissue.
1
1
3
279
One binding site often means choosing potency or selectivity. BARI’s Kevan Shokat & team link two ligands on the same kinase and apply the idea to ABL1 leukemia. In Nature: their lead compound PonatiLink-2 stays potent against resistance and is better tolerated in mice.
1
0
0
137
BARI’s Margaret Wallhagen & colleagues invite nurses to help shape geroscience. Nursing’s prevention-focused, person-centered perspective is a natural fit, and the field will be stronger with that voice in education, research, practice, and policy. nursingoutlook.org/article/S0029-…
0
0
0
91
In Geroscience, BARI’s Scott Bauer reports that walking energies, but not peak fitness, track with urinary symptoms in adults 70+. Higher walking energy cost was linked in incontinence in men. link.springer.com/article/10.100…
1
0
0
102
Blood-brain barrier cell types are undercounted in many single-cell studies. BARI’s Andrew Yang shares a Nature Protocols method to isolate cerebral vessels and recover high-quality nuclei for downstream multi-omics. nature.com/articles/s4159…
1
1
2
212